Cycloastragenol powder

What is cycloastragalinol?

Cycloastraganol powder is also known as triterpene cycloastraganol, with a chemical formula of C30H50O5 and a molecular weight of 490.71. It is a triterpene saponin compound and is mainly obtained by the hydrolysis of astragaloside IV. The substance appears as colorless needle-like crystals with a density of 1.20 g/cm³. Cycloastraganol is the only telomerase activator discovered so far. It delays telomere shortening by increasing telomerase, so it is considered to have anti-aging effects.

CAG is a cycloartane type among the tetracyclic triterpenoids, which is obtained by breaking the two glycosidic bonds of AS-IV. Compared with AS-IV, CAG has enhanced fat solubility and is more easily absorbed through the cell membrane; however, it has poor water solubility and low oral bioavailability. In addition, the structure of CAG contains a cyclopropane group, which has poor acid resistance and can be converted into astragenol (AG, 3) under acidic conditions.

YTBIO has 10 years of industry experience in the field of raw material supply. Regarding cycloastraganol, we supply cycloastraganol 98%, 50%, and 10% specifications, and we ensure product quality and provide competitive prices.

What are the benefits?

1. Cycloastragenol powder has a significant telomerase activating effect, thereby delaying the shortening of telomeres and ultimately playing an anti-aging effect. In addition, it also has potential anti-viral, protective lung damage, anti-depressant, anti-hyperlipidemia and other pharmacological activities.

2. Cycloastragenol extract can effectively improve the skin thickening and infiltration of inflammatory factors in the diseased skin area. For imiquimod-induced psoriasis, it can significantly improve the skin thickening in the diseased area, and at the same time, dose-dependently reduce the concentration of the skin in the diseased area. Levels of infiltrating inflammatory factors.

3. It provides a new source of drugs for the prevention, diagnosis, detection, protection, treatment and research of abdominal aortic disease, which is easy to promote and apply, and can produce huge social and economic benefits in a short period of time.

4. It has a certain delaying effect on the progression of aging-related diseases such as osteoporosis, cardiovascular disease, Alzheimer's disease, and stroke.

5. It can promote melanin synthesis at both the cellular and animal levels and has a good therapeutic effect on vitiligo. The mechanism may be related to the activation of the p38 signaling pathway.

6. It can increase the expression of TERT in brain tissue after cerebral ischemia-reperfusion, which is speculated to be one of the mechanisms by which cycloastragalus reduces cerebral ischemia-reperfusion injury. It can also inhibit neuronal apoptosis during cerebral ischemia-reperfusion, which is achieved by promoting TERT expression.

Research status

As a secondary metabolite of great medicinal value in Astragalus, cycloastragalus has a protective effect on cardiovascular diseases, stroke, fatty liver and other diseases. It can activate telomerase, regulate immunity, promote wound healing and Hair growth etc. However, there are still some problems in the current research on the pharmacological effects of cycloastragalin:

① Relevant in vitro experiments have found that cycloastraganol has a cytotoxic effect at a certain concentration, suggesting that cycloastraganol is not absolutely safe. Its toxic effects on cells still need to be studied in depth, and its safety in animals needs to be further verified;

② The research on cycloastragalin is mostly limited to the target of telomerase activation. Although it has advantages in the development of related health products, it limits its deeper and wider research to a certain extent. At present, Although cycloastragalus has been studied on the adenylate-activated protein kinase pathway, there are still some problems in the research on the pharmacological effects of cycloastragalus. In the future, its protection against diseases such as cardiac fibrosis, congestive heart failure and arrhythmia needs to be further strengthened. Function research, as well as theoretical and experimental research on improving cardiovascular disease risk indicators and regulating endothelial cell homeostasis, for better clinical application. At the same time, the potential of cycloastragalin in the treatment of cerebral ischemia and mental diseases should be fully explored, and its effect on brain neurovascular diseases should be regarded as a new direction for future research.

Cycloastraganol has a significant inhibitory effect on CYP3A4 subenzyme and shows a significant inducing effect on CYP2E1 subenzyme. Wei Baohong, Ye Jing, Xue Baojuan, et al. Effects of continuous intragastric administration of cycloastraganol on rat liver P450 enzyme activity.

Biological activity of Cycloastragenol

CAG has good biological activities such as anti-aging, anti-inflammatory, antibacterial, anti-oxidative stress, liver protection and endothelial protection. In recent years, researchers have conducted extensive studies on the pharmacological effects of CAG through in vitro and in vivo experiments. Studies have found that CAG has certain therapeutic potential for psoriasis-like skin inflammation, pulmonary fibrosis, non-alcoholic fatty liver and other diseases. In the treatment of cardiovascular system diseases, CAG has been found to have preventive and therapeutic effects on heart failure, myocardial fibrosis, myocardial infarction, etc. In addition, CAG also has good effects on neurological and psychiatric diseases, such as depression, Alzheimer's disease, ischemic brain injury, etc.

Based on various biological activities, CAG is expected to become a potential therapeutic drug for many diseases. It is worth mentioning that the combined administration of CAG and paclitaxel can reduce the toxic side effects of paclitaxel in treating gastric diseases. Combining drugs can reduce toxicity while maintaining drug efficacy, and has become a new direction in the research and development of new drugs related to natural products.

Test Report

Cycloastragenol supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality Cycloastragenol extract Cycloastragenol 98% and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

Package & Shipment

Our Company and Factory

Hot tags:Cycloastragenol powder,cycloastraganol 98%,Cycloastragenol extract,Suppliers, Manufacturers, Factory, Buy, price, for sale, producer, free sample, OEM, ODM, private label, white label.