Azelaic Acid Powder

What is Azelaic Acid Powder?

Azelaic Acid Powder, molecular formula C9H16O4, CAS 123-99-9, is a natural saturated dicarboxylic acid, white or off-white crystalline powder, slightly soluble in cold water, soluble in hot water, ether, easily soluble in ethanol. It has antibacterial, acne-dissolving, anti-inflammatory, anti-oxidant and tyrosinase-inhibiting effects, and is well-known in acne treatment. It has no photosensitivity and can be used during the day. Compared with common organic acids such as salicylic acid and fruit acid, it is less irritating and milder.

Azelaic acid has been used for 50 years, after research, scientists also can find it in the secretions of some plants and microorganisms in nature, but the content is too low. At present, it mainly uses unsaturated fatty acids such as oleic acid and its derivatives as raw materials, then produced by oxidative cracking under the combined action of oxidants and catalysts. Now it has been widely used in food (anti-corrosion), daily chemical products, medicine, chemical product intermediates, etc.

What Is Its Characteristics

1) It has no photosensitivity and can be used during the day.

2) When its concentration reaches 10%, the effect is good, because the solubility of high concentration is poor, and affects the effect, which is one of the reasons why it is difficult to be widely used.

3)In the field of anti-acne, it can dissolve oil and fat, dredge excess oil and impurities that block pores, and can inhibit bacteria and anti-inflammation.

4) It is not too irritating and has better antibacterial effect.

5) Compared with antibiotics, it has no drug resistance and can be used for a long time.

6) It has almost common adverse reactions of acids, such as redness, itching, dryness, etc. So it is recommended to use it for the first time, starting with low concentration, small area, and small amount to build tolerance.

7) Our products are all semi-finished raw materials, and need further processing, so please do not consume directly.

What are the benefits of azelaic acid?

1) Antibacterial

Azelaic acid Powder can prevent bacterial protein synthesis, directly inhibit and kill aerobic and anaerobic bacteria on the skin surface and in hair follicles, and can also kill Staphylococcus epidermidis, Pseudomonas aeruginosa, Proteus, Candida albicans, and acne propionic acid. Bacillus and other harmful bacteria.

2) Regulate sebaceous gland function

Excessive levels of the androgen testosterone in the body can lead to hyperfunction of the sebaceous glands in the body, leading to an uncontrolled increase in oil secretion. Azelaic acid can inhibit the conversion of androgens in the body, thereby indirectly preventing excessive secretion of oil.

3) Anti-keratinization

Hair follicle blockage is due to excessive keratosis of the pilosebaceous gland ducts in our body. It can inhibit keratinization and improve acne-like infected skin, especially by reducing the synthesis of less filamentous keratin, which can prevent hyperkeratosis of hair follicles.

4) Anti-inflammatory

It has certain anti-inflammatory properties that can relieve the redness and swelling caused by rosacea. In addition, it can effectively relieve the problems of acne and acne, especially red acne and black and red acne marks on the face.

5) Lighten pigments

By inhibiting the tyrosinase activity of abnormal pigment cells in the body, it effectively inhibits pigment synthesis; in addition, it can also inhibit the DNA alteration and synthesis of abnormal pigment cells and reduce mitochondrial enzyme activity, thus hindering the proliferation of abnormal melanocytes.

6) Regulate hair follicle keratinization

It can reduce the synthesis of filamentous keratin and prevent excessive keratinization of hair follicles. AzA can control epidermal keratinogenesis differentiation and proliferation rate, and has an anti-proliferative effect on keratinocytes.

 Applications of azelaic acid

① Treatment of rosacea: The Chinese Guidelines for the Diagnosis and Treatment of Rosacea (2021 Edition) recommend AzA for the treatment of rosacea. The specific recommendations are: AzA can reduce the expression of serine protease kallikrein 5 and antimicrobial peptides and inhibit the release of cytokines induced by ultraviolet rays. , improve rosacea papules and pustules. Commonly used creams or gels with a concentration of 10%, 15% or 20%, twice a day. Level of evidence: Level A for papules and pustules; Level of recommendation: Recommended. The standard management options for rosacea updated by the International Rosacea Society Expert Committee in 2019, and the British Association of Dermatologists Rosacea Patient Management Guidelines (2021 Edition), also recommend AzA as the first-line option for topical treatment of papulopustular rosacea.

②Treatment of acne: Chinese Acne Treatment Guidelines (2019 revised edition) recommends: AzA has inhibitory effects on Propionibacterium acnes, anti-inflammatory or mild exfoliation effects, and is a second-line topical drug for mild to moderate acne. AzA is also recommended in the Acne Vulgaris Treatment Guidelines published in the Journal of the American Academy of Dermatology, with a recommendation strength of A and an evidence level of Class I.

③Treatment of chloasma: Chinese Expert Consensus on the Diagnosis and Treatment of Chloasma (2021 Edition) recommends 15%~20% AzA cream for topical treatment of chloasma, 2 times/d, for about 6 months, mainly for simple pigmented yellowing Brown spots.

④Treatment of other skin diseases: Various other skin diseases can cause excessive pigmentation, such as malignant melanoma, post-inflammatory hyperpigmentation, solar keratosis, burns and other physical trauma. Topical application of AzA has been reported to produce satisfactory clinical results in the treatment of pigmentation.

How to choose azelaic acid concentration

Daily oil control and acne skin repair: 5% concentration of azelaic acid

Remove blackheads and acne: 15% concentration of azelaic acid

Lighten acne marks: Compound 15% concentration azelaic acid

Remove redness, swelling and acne: 20% concentration azelaic acid

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YTBIO is committed to providing customers with the highest-quality Pure Azelaic acid Powder bulk and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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