Monk Fruit Extract Powder

Do you know Monk Fruit Extract Powder？

Monk fruit extract powder is a natural sweetener derived from the dried fruit of Monk fruit. It has a significant sweetness characteristic, but with a unique licorice-like aftertaste. Its main active ingredients include triterpenoid glycosides mogrosides V and IV, among which mogroside V is particularly sweet, reaching 256-344 times that of sucrose. In addition, it also contains fructose, glucose and 26 inorganic elements. Due to its zero-calorie characteristics, it is widely used in many fields, including food, beverages, pharmaceutical preparations and cosmetics industries. It is a natural sugar substitute product with important application value.​​​​​​​

Main components of Monk Fruit Extract Powder

The main components of monk fruit extract are as follows, which together give monk fruit extract its unique sweetness and health benefits

Triterpenoid saponins

Mogroside: This is the main component of monk fruit extract and the source of its sweetness. Monk fruit glycoside is a non-sugar sweetener with a sweetness hundreds of times that of sucrose and extremely low calories. It is often used in sugar-free foods and beverages.

Siamenoside: It is a triterpenoid saponin in monk fruit, which has a certain sweetness and is usually present as a concomitant component of monk fruit glycoside.

Flavones

Grosvenorine: It is a flavonoid glycoside with antioxidant effects

Organic acids

Monk fruit contains a small amount of organic acids, such as citric acid, malic acid, etc. These ingredients may affect the taste and flavor of monk fruit.

Polysaccharides

Monk fruit contains a variety of polysaccharides, which may have certain physiological activities, such as immune regulation, etc.

Vitamins and minerals: Monk fruit is rich in vitamin C and minerals such as manganese, iron, and nickel.

YTBIO：Provide You with Monk Fruit Extract Powder Mogroside V

​​​​​​​Health Benefits of Monk Fruit Extract Powder

Monk fruit extract can significantly reduce the number of coughs caused by irritants and prolong the incubation period of coughs. It promotes the increase of tracheal secretions and helps the discharge of sputum, thereby relieving coughs and throat discomfort. It is often used to treat respiratory diseases such as lung heat and dry cough, bronchitis and cold cough

·Antioxidant

The flavonoids and polyphenols in monk fruit extract have strong antioxidant capacity and can effectively remove free radicals in the body. These antioxidants help slow down the aging process and prevent chronic diseases by neutralizing free radicals, reducing oxidative stress, and protecting cells from damage.

·Lowering blood sugar and blood lipids

Monk fruit extract powder can lower blood sugar and blood lipid levels, which is beneficial for diabetic patients and people with dyslipidemia. It may work by improving insulin sensitivity, promoting glucose metabolism, and inhibiting fat absorption, helping to control the development of diabetes and hyperlipidemia and reduce the risk of related complications.

​​​​​​​Blood sugar regulation mechanism

·Enhance immunity

The polysaccharides and other active ingredients in monk fruit extract can stimulate the immune system and improve the body's disease resistance. It enhances the body's immune function by enhancing the activity of immune cells and promoting the secretion of immune factors, which helps prevent infection and disease.

Application Areas of Monk Fruit Extract Powder

·Health products

Monk fruit extract can be used in hypoglycemic health products

·Medical field

Monk fruit extract is used in cough and phlegm medicine

·Food industry

As a natural high-sweetness sweetener, monk fruit extract is widely used in beverages, candies, baked goods and other fields to replace sucrose and meet the needs of healthy low sugar.

·Cosmetics industry

With its antioxidant properties, monk fruit extract is added to skin care products to help resist free radicals and delay skin aging. It can also be used in toothpaste, mouthwash, etc. to help protect oral health.​​​​​​​

Mogroside: Health promotion and food application​​​​​​​

As a medicine and food homologous substance, monk fruit is a "generally recognized safe" sweetener. It has been used in traditional Chinese medicine for more than 200 years to clear heat and moisten the lungs. Modern pharmacological studies have shown that it has multiple activities such as antioxidant, anti-inflammatory, liver protection and anti-diabetic, which is attributed to its various chemical components such as triterpene glycosides, flavonoids and polysaccharides. As the main sweet ingredient in monk fruit, mogroside V (M5) has a sweetness of about 260 times that of sucrose and has multiple pharmacological activities such as anti-inflammatory, lipid-lowering, antioxidant, lung function recovery and neuroprotection, showing broad development value in the food industry, health products and pharmaceutical industries.

M5:food and medicinal applications

Extraction and purification of M5

M5 can be obtained from monk fruit by solvent extraction, high pressure assisted extraction and continuous countercurrent extraction. It is usually purified by column chromatography separation techniques such as macroporous adsorption resin, anion exchange resin and octadecylsilane bonded silica gel. For example, the purification factor of M5 by HZ806 resin can reach 10.7%. Ultrahigh pressure extraction combined with C18 column purification can make the purity of M5 reach 96.1%. In terms of pharmacokinetics, M5 mainly undergoes metabolic processes such as deglycosylation, hydroxylation, dehydrogenation and glycosylation in experimental animals, and its metabolites are unevenly distributed in rat organs. For example, the main bioactive metabolite mogroside IIE is highly concentrated in the heart, liver, spleen and lungs. M5 is mainly excreted through urine, while its metabolites are mainly excreted through feces.

At the same time, pathological conditions such as type 2 diabetes can affect its pharmacokinetic characteristics, such as increasing the Cmax and AUC0-t values of the metabolite mogroside IIIA1 and shortening the MRT0-t.

Health effects of M5

M5 has shown a wide range of health benefits in a variety of disease models. In respiratory diseases, it can reduce inflammatory cell infiltration and inflammatory factor release by inhibiting signaling pathways such as PI3K/Akt, NF-κB and JAK-STAT, and improve asthma and acute lung injury. For diabetes, it can improve insulin resistance, promote insulin secretion, and inhibit intestinal α-glucosidase activity to control blood sugar by regulating the PI3K/Akt signaling pathway. In obesity intervention, it can regulate the expression of genes and proteins related to lipid metabolism, affect the composition of intestinal flora and the synthesis of short-chain fatty acids, and reduce fat accumulation.

In addition, M5 can improve ulcerative colitis by inhibiting endoplasmic reticulum stress and regulating AMPK signaling pathway, reduce non-alcoholic fatty liver by activating AMPK signaling pathway, improve depression, schizophrenia, Parkinson's disease and other brain diseases by anti-inflammatory, antioxidant and regulating related signaling pathways, and improve female reproductive capacity by improving mitochondrial function and reducing oxidative stress.

Application of M5 in food and medicine

In the field of food, M5, as a natural high-sweetness sweetener, can be used in beverages, candies, baked goods, etc. For example, plant-based milk tea containing 0.55g M5 per liter has low calories and low fat, which is suitable for patients with hyperlipidemia and obesity; it can also be used as a functional food ingredient to develop products with antioxidant and anti-aging effects, such as formula goat milk powder containing M5 can improve serum indicators of aging mice.

In the pharmaceutical field, M5 can be used as a natural cosolvent to improve the solubility of poorly soluble drugs, such as the solubility of paclitaxel-M5 solid dispersion increased by about 375 times. It can also be used as an emulsion stabilizer to interact with whey protein to enhance the stability of the emulsion, such as the αLA/M5 emulsion treated with US-HPH did not stratify for 45 days.

Existing Difficulties and Prospects

M5 is widely used and has many benefits, but it still faces some challenges, such as complex extraction process, low separation efficiency, high cost, limited large-scale production, and its thermal stability and structural changes under different food processing conditions need to be systematically studied, and its safety also needs further evaluation.

In the future, we can focus on the large-scale synthesis of M5, explore its target and multi-pathway molecular mechanism, explore the composite products of M5 and other functional ingredients, such as combining with extracts of medicinal and edible plants to prepare solid beverages with synergistic effects, and strengthen its application research as a drug carrier in targeted drug delivery systems.

Safety and supervision of mogrosides

Monk fruit is one of the earliest "medicine and food" substances in China. The mogrosides extracted from it can play a role in expectoration and antitussive, anti-oxidation, balancing blood sugar levels, inhibiting cancer cells, neuroprotection, inhibiting fat production, etc., and can be used in food, functional food and medicine.

Unlike other sugar substitutes such as stevia, monk fruit sugar is applicable to two sets of standards for food and food additives. It is safe and has a wider range of applications and is not restricted by the amount of addition. In addition, monk fruit powder and monk fruit concentrated juice, as natural raw materials, can implement food standards, be added to food and beverages, and be directly labeled as "monk fruit powder/monk fruit juice".

The "National Food Safety Standard Food Additives Usage Standard" issued by the National Health Commission of China at the end of 2014 classifies mogrosides as food additives that can be used in various foods in appropriate amounts according to production needs, and are not restricted by the amount of addition. In 2017, the national food safety standard "Food Additives - Mogrosides" was officially implemented, which made detailed provisions on the sensory requirements, physical and chemical indicators and inspection methods of mogrosides.

In addition, mogrosides have also been approved by official departments in Canada, Japan, Singapore, South Korea, Thailand, Singapore, the United Kingdom and other countries. Children, diabetics, pregnant women and nursing mothers can eat it. Japan has been importing monk fruit from China in large quantities since the 1990s. In addition to using it as a natural sweetener to make throat lozenges, functional beverage effervescent tablets, etc., it has also used mogrosides to develop a variety of health foods, such as anti-allergic granules, weight loss foods, blood sugar-lowering foods, and immunity-enhancing foods. The United Kingdom has developed cube sugars made from a mixture of soluble starch and mogrosides.

Recommended use of mogrosides

Recommended method 

Beverage seasoning

When brewing directly, take 1-2 grams (about 1/4 teaspoon) each time and dissolve it in warm water or tea, and adjust according to taste.

Cooking and baking

Due to its high sweetness, the recommended ratio of replacing sucrose is 1:150-200 (for example, if the recipe requires 30 grams of sugar, 0.15-0.2 grams of mogroside can be used).

Health care products or pharmaceutical excipients

Some tablets or granules containing mogrosides need to be taken according to the product instructions. Usually, the total daily intake does not exceed 1.5 grams and is used in divided doses.

​​​​​​​Special populations

Children and pregnant women

Although it is a natural ingredient, there is a lack of long-term safety research. It is recommended that children, pregnant women and breastfeeding women reduce their use, or control the dosage under the guidance of a doctor.

People with gastrointestinal sensitivity

Overdose may cause bloating or diarrhea. It is recommended to start with the minimum dose (such as 0.3 grams/day) and gradually adapt.

Patients with chronic diseases

If you are taking antihypertensive drugs or blood sugar regulating drugs, you need to confirm with your doctor whether the dosage needs to be adjusted to avoid interactions.

YTBIO:Professional supplier of Monk Fruit Extract Powder

YTBIO has a modern production base, a strict quality inspection system and a professional R&D team. We always adhere to the concept of "quality first" and are committed to providing customers with high-quality monk fruit extract powder products. Whether you need sample testing, product customization, or technical consultation, our professional team will provide you with timely and efficient service support.Welcome to contact us at any time, YTBIO looks forward to working with you to create a new future of healthy sweetness!​​​​​​​​​​​​​​