Neutral Protease

What is Neutral Protease?

Neutral Protease is extracted from Bacillus subtilis by fermentation. It is an endonuclease that can be used for various protein hydrolysis treatments. It can hydrolyze the N-terminal peptide bond of non-J amino acid residues and is classified as an amino endopeptidase. Its mild proteolytic action makes the enzyme particularly suitable for separating primary and secondary cells because it can maintain the integrity of the cell membrane.

Its activity is highest at neutral pH and it can break down proteins into smaller peptide chains and amino acids, thereby promoting protein digestion and absorption. As an enzyme substance, it plays a role in breaking down proteins in organisms. This enzyme exists in different organisms, such as animals, plants and microorganisms, and they play a vital role in the digestion process. It has the advantages of high efficiency and cleanliness, and is widely used in feed, baking, condiments, beer and other industries.

Features

Substrate specificity
Mainly hydrolyzes peptide bonds provided by hydrophobic macromolecular amino acids such as leucine, phenylalanine, and tyrosine, and has different hydrolysis abilities for different types of proteins.

Thermostability
Generally, the thermal stability is poor and it is easily inactivated at high temperatures, but some special strains have good thermal stability.

Safety
Neutral Protease is generally considered safe, has no toxic side effects, and is widely used in food, medicine and other fields.

High catalytic efficiency
Under suitable conditions, it can efficiently catalyze protein hydrolysis reactions and improve production efficiency.

Adjustability
Through genetic engineering and fermentation processes, its activity and specificity can be precisely regulated to meet different application requirements.

Main Sources

As a type of enzyme that can catalyze the decomposition of proteins, proteases can break peptide bonds to produce amino acids, polypeptides or peptide fragments. According to the optimal pH value of the reaction, they can be divided into acidic, neutral and alkaline proteases. The optimal pH value of neutral proteases is generally 7.0~8.0. Most of them are metalloproteases, and their activity is closely related to certain divalent cations, such as Mg2+, Ca2+, Mn2+, Zn2+, etc.

Physiological Functions​​​​​​​

Defense function
Participate in inflammatory response: During the inflammatory response, neutrophils release neutral proteases to help clear pathogens, but excessive release may cause tissue damage. These proteases can degrade extracellular matrix proteins, promote the movement of neutrophils to the site of inflammation, and participate in regulating the inflammatory response.

Tissue repair and remodeling
Promote tissue repair: It also plays a role in the process of tissue repair, creating conditions for the growth of new tissues by degrading damaged or aged extracellular matrix proteins.
Participate in tissue remodeling: During the process of tissue remodeling, it can regulate the dynamic balance of the extracellular matrix and promote the maintenance of the normal structure and function of the tissue.

Digestive function
It can break down the protein in food and convert it into small molecule peptides and amino acids, thereby promoting the digestion and absorption of protein. This process is essential for maintaining normal physiological functions of the human body, especially in the stomach and small intestine.

Application Areas

Food
In the field of food processing, it is used to improve the properties of gluten protein, enhance the plasticity and fermentability of dough, and thus improve the taste and flavor of bread and other baked goods. In addition, it is also used for protein hydrolysis to produce high value-added protein peptides and amino acids.

Beer Industry
In beer production, it is used to decompose protein into peptides and free amino acids to reduce the cold turbidity phenomenon in beer production.

Medicine
Used in medicine, it can be used to treat diseases such as inflammation and indigestion. It can also be used to prepare biopharmaceutical raw materials such as polypeptide drugs.

Feed
It can be added to feed as an exogenous enzyme to help animals digest and absorb protein, thereby improving the nutritional value and utilization rate of feed and reducing the waste of protein resources.

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Neutral Protease and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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