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What are pentapeptides?
Pentapeptide is palmitoyl pentapeptide-4, which is an active small molecule peptide that can be directly absorbed by the human body.
It has the effect of promoting collagen production and repairing damaged skin. It is an effective anti-aging ingredient and has a significant effect in improving static lines on the skin. It is also used in cosmetics as a skin conditioner, antioxidant and moisturizer.
Pentapeptide has five amino acids and a liposome structure. It has good compatibility with the skin and has a significant skin care effect. It is one of the most famous collagen peptides in cosmetics. It is the darling of cosmetic engineers and is used by many Used by cosmeceuticals and major international brands! It has extremely high hydrophilicity, promotes the production of hyaluronic acid, increases the skin's moisture content, and makes it silky, supple, and elastic.
Its anti-aging activity is much higher than vitamin A and vitamin C, and its dosage is extremely low, safe and has no side effects. In 2015, IFSCC (International Society of Cosmetic Formulators) specially awarded the "25 Years Innovation Award" in recognition of its greatest influence in the cosmetic raw material industry in the past 25 years.
Pentapeptide was the first to be used by the dermatology medical community to directly act on the dermis layer with vitamin A and other anti-aging ingredients to promote collagen proliferation and achieve skin firming. When combined with other moisturizing ingredients, it can accelerate skin tightening.
Pentapeptide is a type of peptide and belongs to the signaling peptide category. Anyone who has studied biology will be familiar with peptides. Peptides are a small molecule protein that exists in the human body. Proteins are hydrolyzed and converted into extremely small molecular weight substances composed of several amino acids. Stable in nature and easily absorbed by the human body. Pentapeptide refers to a peptide composed of five amino acids connected by peptide chains. Compared with traditional hydrolyzed protein peptides, the five-peptides in skin care products have a more uniform peptide sequence, so they can have specific anti-aging functions.
The mechanism of anti-wrinkle and anti-aging
① Stimulate collagen regeneration and increase skin thickness
Palmitoyl Pentapeptide powder is an accurate simulation of MATRIKINES (messenger peptides), the hydrolysis product of procollagen α1 chain. MATRIKINES regulate cell activity by interacting with cell-specific receptors.
It can activate certain genes involved in extracellular matrix renewal and cell proliferation processes, increase the activity of stromal cells, promote the production of type I and III collagen and fibronectin, and make the collagen inside the skin increase, plump and orderly, thus Increase skin thickness to resist aging and reduce fine lines.
As shown in the figure above, in experiments on human skin and corneal fibroblasts, pentapeptide promoted collagen production, and the amount of collagen produced was related to the concentration of pentapeptide.
②Liposome structure, good compatibility
Pentapeptide has a liposome structure and is well compatible with the skin. As a protein fragment, it can easily pass through the stratum corneum gap and enter the dermis to exert better effects. It has good skin-friendly properties and is easy to use. absorb.
As a member of the signaling peptides, pentapeptides can promote the synthesis of matrix proteins, especially collagen, by increasing the activity of stromal cells, while also increasing the formation of elastin, hyaluronic acid, glycosaminoglycans and fibronectin. The amount makes the skin elastic and achieves the purpose of anti-aging. At the same time, compared with other anti-aging substances, peptides, as protein fragments, can easily pass through the stratum corneum gap and enter the dermis, exerting their due effects and having a higher application rate.
However, even if the application rate is very high, peptides have a certain action cycle (mostly four weeks), so peptide skin care products must be used for a long time in daily use. In addition, the combination of peptides and other functional ingredients can increase its ability to penetrate the skin and exert anti-aging effects. For example, ProX Apple Skin Essence combines five peptides, two peptides and cell-level B3 (nicotinamide) factor to achieve the effect of restoring apple skin.
What are the benefits?
1. Firm skin
Palmitoyl Pentapeptide is originally a small molecule protein in the human body. For areas that need to modify fine lines and wrinkles, it can be quickly converted into the nutrients needed by cells to rejuvenate the skin and make it look like a new baby. It can quickly fill the holes and gaps in lines and perfectly repair the face. Wrinkles, skin returns to a youthful, smooth and tender state.
2. Remove red blood filaments
It can effectively inhibit the erosion of facial skin by pathogenic bacteria such as Pseudomonas aeruginosa and acne bacteria; reduce facial red blood filaments and telangiectasia, improve red blood filaments, effectively resist skin inflammation, and reduce allergic discomfort.
3. Bright eyes
Improve eye lymphatic microcirculation, skin elasticity and anti-edema function, promote the proliferation of collagen and hyaluronic acid, increase skin moisture content and elasticity, and relieve eye bags and dark circles.
4. Deep hydration
Promote the growth of skin collagen and remind the skin to increase moisture retention, giving the skin the ability to resist daily stress stimuli and challenges. It is especially suitable for improving fragile, tired and dull skin and restoring its vitality.
5. Fight wrinkles
It has a similar nerve conduction inhibition function, which can relax expression lines caused by nervous tension, slow down facial wrinkles and cell aging, and long-term use can increase the resilience of cells, make the skin younger, and improve static lines.
Nowadays, the initial research on the anti-aging pentagonal peptide has made it the main ingredient in anti-aging skin care products, and the follow-up research is also very exciting. Through this article, I hope to increase most people’s understanding of the anti-aging substance Pentapeptide, which can be regarded as a small exploration.
Pentapeptide is the darling of cosmetic engineers. Mainly used by mainstream international brands for lifting, firming and eye care. It is extremely hydrophilic, promotes the production of hyaluronic acid, increases the moisture content of the skin, and makes it silky, supple, and tender. Full of elasticity. The dense keratin of the skin blocks skin care factors from penetrating into the dermal layer of the skin, so most skin care products only stay on the surface of the skin. The bioactive five-peptides can enter the dermis, promote collagen proliferation, increase skin moisture content, increase skin thickness and reduce fine lines.
Palmitoyl Pentapeptide powder has only 13 amino acids, has a small molecular weight and is easily absorbed. One of its significant effects is that it can promote collagen proliferation and indirectly repair micro-damage to the human oral mucosa. The anti-aging effect of five peptides can prevent and improve gum recession. In addition, five peptides can promote the proliferation of hyaluronic acid and elastic fibers, and can effectively activate the synthesis of hyaluronic acid, which is crucial for maintaining oral moisture and relieving dry mouth.
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