Silk Fibroin Powder

What is Fibroin powder?

Silk Fibroin Powder, also known as: silk fibroin. Silk fibroin is a natural polymer fiber protein extracted from silk. Its content accounts for about 70% to 80% of silk. It contains 18 kinds of amino acids, of which glycine, alanine and serine account for more than 80% of the total composition. In this issue, we will introduce you to the performance indicators of silk protein and its new applications in the fields of biomedical materials and beauty. 

Silk protein powder is an important natural biopolymer material with excellent mechanical properties, biocompatibility, biodegradability, and ease of chemical modification, making it an important biomaterial in regenerative medicine research. In recent years, regenerative medicine materials based on silk fibroin have been widely used in tissue repair and regenerative medicine such as bones, skin, nerves, and pancreatic islets. 

The role of silk fibroin materials in regulating cell function has gradually been elucidated and has become its guiding design and It is an important reference for constructing the structure of medical silk fibroin materials and accelerating the application of silk fibroin materials in clinical medicine. Other areas of its application include food, cosmetics and other fields.

Indicators of silk protein:

Technical indicators: ① Appearance: light yellow transparent liquid, no specific odor, easily soluble in water. ② Biuret reaction is positive. ③ pH value 6~7. ④Protein content: >/14%. ⑤Amino acids: 17 types in total, containing more than 87mg per ml. ⑥Ash content: less than 1%. ⑦Heavy metals mercury, arsenic and lead are below 1ppm respectively. ⑧The total number of bacteria (pieces/m1) ≤ 10.

Quality index: Silk fibroin is a protein extracted from silk. It has good biocompatibility and can be prepared into various forms of materials such as films, gels, and microcapsules. Due to its unique physical and chemical properties, it is currently used Silk fibroin materials have been widely studied in the field of biomedical materials, such as immobilized enzyme materials, cell culture substrates, drug sustained release agents, artificial organs, etc.

Advantages of Fibroin

1 Nervous tissue repair

Nerve trauma repair is a major problem in today's medicine. Irregular nerve wounds caused by trauma, disease, etc., and the lack of necessary filling during the recovery process will lead to the formation of neuromas. Therefore, autologous transplantation is still considered the most effective repair method so far. For a long time, due to the severe shortage of donors and the slow progress in research on alternative materials, a large number of patients have not been able to receive timely and effective treatment. Non-nerve materials for nerve repair include silicone tubes, skeletal muscles, arterial or venous blood vessels, and chitin. Research in the past decade has shown that ideal nerve repair materials must meet the following conditions: First, the substitute must be completely degraded, have no tissue toxicity, and be able to promote the regeneration of nerve cells. Non-degradable materials need to be removed through later surgery. The second is that the artificial nerve exists in the recipient for a long time to satisfy the regenerated axon through the distal anastomosis. Third, the substitute has enough space and surface permeability to meet the growth of Schwann cells and the transportation of nutrients.

2 skin repair

Human skin is mainly divided into epidermis and dermis. The epidermis is the outermost layer of the skin and is in contact with the external environment. It mainly plays a protective role. The epidermis is divided from the inside out into: basal cell layer, granular layer, clear cell layer and cornified layer. Under normal circumstances, the basal cell layer continues to differentiate, moves outward, and constantly replaces senescent cells in the cornified layer. Small-area wounds can be repaired through the crawling action of epidermal cells. Moreover, research on artificial skin using the crawling and repairing ability of skin cells has been put into practice. Silk fibroin membrane not only has good water and air permeability, but also has strong adhesion to the wound surface without occupying space (that is, it does not affect the growth of autologous skin under artificial skin coverage). It is not penetrated by bacteria and is not exposed to moisture. It is softer and adheres well to the wound. In addition, the silk fibroin membrane is smooth, soft and non-irritating, so it is an ideal material for artificial skin and wound coverage.

3Biotechnology

In the field of biotechnology, silk fibroin membranes can be used as carriers for immobilized enzymes and for the preparation of biosensors. Silk Fibroin Powder is a natural polymer protein with a unique molecular structure, excellent mechanical properties, good moisture absorption and heat preservation properties, and antimicrobial properties. It is an ideal enzyme immobilization carrier material for medical and biochemical applications. , fermentation and chemical analysis and other fields.

4 cosmetics

As early as the Ming Dynasty, Li Shizhen recorded in his medical masterpiece "Compendium of Materia Medica": natural silk can make the skin beautiful, eliminate dark spots, and can also treat purulent skin diseases. In terms of cosmetics, silk protein mainly comes in two forms: silk fibroin powder and silk peptide. Silk fibroin powder not only has the unique soft luster of silk protein and the function of absorbing ultraviolet rays and resisting solar radiation, but is also smooth, delicate, has good air permeability and strong adhesion. It can absorb and release water with changes in environmental temperature and humidity, which is good for the stratum corneum of the skin. Moisture has a better retention effect. Therefore, silk fibroin powder is an excellent basic material in beauty cosmetics. Silk peptide has a good moisturizing effect; it has strong permeability, can penetrate the stratum corneum and combine with epithelial cells, participate in and improve the metabolism of epithelial cells, nourish cells, and make the skin moist, soft, elastic and shiny; it has good composition It has film properties and can form a protective film on the surface of skin and hair. This film has good flexibility and elasticity; it is anti-ultraviolet radiation. The tyrosine in silk fibroin peptide reacts photochemically with ultraviolet rays, which can block and reduce ultraviolet radiation. Infringement of the human body; inhibiting the production of melanin in the skin, silk peptide protein has the effect of inhibiting tyrosinase activity, thereby inhibiting the production of melanin.

5 Nutritional and health functions

5.1 relieve hangover and protect liver

In recent years, the hangover-relieving and liver-protecting functions of silk fibroin have been utilized to make functional foods. Tussah silk fibroin anti-hangover and liver protection functional food is made from tussah silk fibroin nanopowder and traditional Chinese medicine for both medicinal and food use as raw materials, and is refined using nanotechnology. It can effectively protect the human body and reduce the damage of alcohol.

5.2 Lower blood sugar

Nowadays, there are many hypoglycemic drugs such as sulfonylureas, biguanides, and thiazolidinediones. However, long-term use of these drugs may have serious toxic and side effects. Replacing these Western medicines with effective, non-toxic and side-effect natural medicines or foods to treat diabetes will be a great boon for diabetic patients. A large number of studies in medicine have already shown that α-glucosidase inhibitors can effectively prevent and treat diabetes.

5.3 Other functions

According to the amino acid composition of Bombyx mori silk fibroin, it can be seen that silk fibroin contains tyrosine. Tyrosine can be converted into dopamine after a certain process. Dopamine can inhibit nerve conduction in the central nervous system. Dopamine deficiency can cause Parkinson's disease. For patients with Parkinson's disease, consuming silk fibroin powder can supplement tyrosine and effectively prevent and treat Parkinson's disease.

The skin care properties of silk protein include the following:

1. It has the function of naturally moisturizing and nourishing the skin.

Silk Fibroin Powder has good moisture absorption and release properties. Its molecular structure has many hydrophilic genes on the surface of the molecular three-dimensional structure. This structure shows that silk protein is a natural humidity-regulating factor and has a good moisturizing effect.

Experiments show that at a temperature of 27°C, a relative humidity of 86%RH, and a moisture absorption time of 12 hours, the moisture absorption rate of a 2.5% fibroin solution is equivalent to the moisture absorption rate of 48% glycerol. That is, adding a small amount of silk protein solution to cosmetics can obtain good moisturizing and hygroscopic properties. At present, cosmetics with silk protein as the main additive are available on the market, such as moisturizers, facial cleansers, facial cleansers, shower gels, etc.

2. It has the effect of inhibiting the production of skin melanin.

Studies have found that Fibroin powder has the property of inhibiting tyrosinase activity. Because the high proportion of hydroxyl amino acids in silk protein is complexed with trace elements such as copper and iron, it affects the normal performance of tyrosinase activity.

If you regularly apply cosmetics containing silk protein on your skin, it can effectively inhibit the production of melanin in the skin and keep the skin white and tender. Tyrosine, tryptophan, phenylalanine, etc. in silk protein can effectively absorb ultraviolet rays.

3. Promote skin tissue regeneration and prevent chemical damage

Silk protein is very effective in promoting skin wound healing. Silk protein is non-irritating and speeds wound healing. Cosmetics containing silk protein are also effective in preventing skin chappedness. At the same time, silk protein can also resist the erosion of the skin by chemicals such as sunlight, microwaves, acids and alkalis, and atmospheric pollutants. It can well inhibit the generation of reactive oxygen species and prevent skin wrinkles and aging.

4. Fibroin also has antioxidant function

Melalton, which is chlorinated using active oxygen, has important medical value in treating common diseases such as cancer, arteriosclerosis, and diabetes, or in protecting the skin. The experimental results show that the lipids were oxidized at 37°C for 120 minutes, and the oxidation results were measured when adding silk protein or BSA. The control value of the oxidation amount is 100%, expressed as a relative value.

As the amount of natural Fibroin increases, the oxidized lipids decrease, confirming that silk protein has antioxidant capabilities, and that silk proteins are more effective than vitamin C, which has antioxidant functions.

Main indicators:

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Yuantai Organic Bio is committed to providing customers with the highest-quality Pure silk fibroin bulk and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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