Silk Fibroin Powder

What is Fibroin powder?

Silk Fibroin Powder, also known as: silk protein. Silk fibroin is a natural polymer fiber protein extracted from silk. Its content accounts for about 70% to 80% of silk. It contains 18 kinds of amino acids, of which glycine, alanine and serine account for more than 80% of the total composition. In this issue, we will introduce you to the performance indicators of silk protein and its new applications in the fields of biomedical materials and beauty. It is an important natural biopolymer material with excellent mechanical properties, biocompatibility, biodegradability, and ease of chemical modification, making it an important biomaterial in regenerative medicine research. In recent years, regenerative medicine materials based on silk fibroin have been widely used in tissue repair and regenerative medicine such as bones, skin, nerves, and pancreatic islets. The role of silk fibroin materials in regulating cell function has gradually been elucidated and has become its guiding design and It is an important reference for constructing the structure of medical silk fibroin materials and accelerating the application of silk fibroin materials in clinical medicine. Other areas of its application include food, cosmetics and other fields.

Indicators of silk protein

Technical indicators: ① Appearance: light yellow transparent liquid, no specific odor, easily soluble in water. ② Biuret reaction is positive. ③ pH value 6~7. ④Protein content: >/14%. ⑤Amino acids: 17 types in total, containing more than 87mg per ml. ⑥Ash content: less than 1%. ⑦Heavy metals mercury, arsenic and lead are below 1ppm respectively. ⑧The total number of bacteria (pieces/m1) ≤ 10.

Quality index: Silk fibroin is a protein extracted from silk. It has good biocompatibility and can be prepared into various forms of materials such as films, gels, and microcapsules. Due to its unique physical and chemical properties, it is currently used Silk fibroin materials have been widely studied in the field of biomedical materials, such as immobilized enzyme materials, cell culture substrates, drug sustained release agents, artificial organs, etc.

Test Report

The Skin Care Properties of Silk Fibroin Powder

1. It has the function of naturally moisturizing and nourishing the skin.

Silk Fibroin Powder has good moisture absorption and release properties. Its molecular structure has many hydrophilic genes on the surface of the molecular three-dimensional structure. This structure shows that silk protein is a natural humidity-regulating factor and has a good moisturizing effect.

Experiments show that at a temperature of 27°C, a relative humidity of 86%RH, and a moisture absorption time of 12 hours, the moisture absorption rate of a 2.5% fibroin solution is equivalent to the moisture absorption rate of 48% glycerol. That is, adding a small amount of silk protein solution to cosmetics can obtain good moisturizing and hygroscopic properties. At present, cosmetics with silk protein as the main additive are available on the market, such as moisturizers, facial cleansers, facial cleansers, shower gels, etc.

2. It has the effect of inhibiting the production of skin melanin.

Studies have found that Fibroin powder has the property of inhibiting tyrosinase activity. Because the high proportion of hydroxyl amino acids in silk protein is complexed with trace elements such as copper and iron, it affects the normal performance of tyrosinase activity.

If you regularly apply cosmetics containing silk protein on your skin, it can effectively inhibit the production of melanin in the skin and keep the skin white and tender. Tyrosine, tryptophan, phenylalanine, etc. in silk protein can effectively absorb ultraviolet rays.

3. Promote skin tissue regeneration and prevent chemical damage

Silk protein is very effective in promoting skin wound healing. Silk protein is non-irritating and speeds wound healing. Cosmetics containing silk protein are also effective in preventing skin chappedness. At the same time, silk protein can also resist the erosion of the skin by chemicals such as sunlight, microwaves, acids and alkalis, and atmospheric pollutants. It can well inhibit the generation of reactive oxygen species and prevent skin wrinkles and aging.

4. Fibroin also has antioxidant function

Melalton, which is chlorinated using active oxygen, has important medical value in treating common diseases such as cancer, arteriosclerosis, and diabetes, or in protecting the skin. The experimental results show that the lipids were oxidized at 37°C for 120 minutes, and the oxidation results were measured when adding silk protein or BSA. The control value of the oxidation amount is 100%, expressed as a relative value.

As the amount of natural Fibroin increases, the oxidized lipids decrease, confirming that silk protein has antioxidant capabilities, and that silk proteins are more effective than vitamin C, which has antioxidant functions.

Silk Fibroin: Anti-aging Mechanism

1. Silk Fibroprotein Reverses Fibroblast Senescence

In a UVB-induced senescent cell model, silk fibroin treatment reduced the number of cells positive for senescence markers (β-galactosidase), decreased SASP factor (IL-6, p16, p21) expression, accelerated cell proliferation, and restored the cell morphology from a "round and plump" shape to a "spindle-shaped" shape. After blocking the inflammatory pathway with the NF-κB inhibitor (BAY 11-7082), PLLA cells essentially lost their collagen-promoting ability (inflammation-dependent), while silk fibroin still stably promoted type I/III collagen secretion without increasing MMP-1/3 or showing p-p65 nuclear translocation. Histological sections showed fibrosis (high α-SMA expression) in the PLLA group, while the silk fibroin group showed almost no fibrosis.

Conclusion: Silk fibroin can directly awaken senescent fibroblasts, its action is independent of inflammation, and there is no risk of fibrosis.

2. Silk fibroin reduces collagen degradation

Transcriptomic/proteomic analysis identified the core pathway: ROS-MAPK (JNK)-AP-1 (c-Jun)-MMP (1/3). UVB leads to increased ROS → activation of JNK → upregulation of AP-1 → increased MMP → collagen degradation.

The role of silk fibroin: reduces ROS, repairs mitochondrial function; inhibits JNK activation; downregulates c-Jun/AP-1; reduces MMP-1/3, protecting collagen; simultaneously upregulates type I/III collagen and elastin expression.

3. Multi-model validation

3D skin organoids: UVB reduced collagen density by 72.7%, and silk fibroin injection significantly restored collagen, epidermal thickness, and elasticity parameters.

Photoaged nude mice: Silk fibroin inhibited MMP-1 and AP-1 overexpression and reduced collagenase activity.

Bama miniature pigs (structure most similar to humans): After 30 days of UVB irradiation, skin became rough, thickened, and collagen decreased. Silk fibroin increases type I/III collagen and elastin fibers, inhibits the MAPK/AP-1 pathway, and reduces MMP-1/AP-1. While PLLA increases collagen, it does not regulate the MAPK pathway.

Conclusion: Consistent multi-model studies confirm that silk fibroin combats photoaging by regulating the ROS-MAPK-AP-1-MMP pathway, with stable effects and a clear mechanism.

DOI： 10.1016/j.bioactmat.2025.12.006

Main Applications

Cosmetics and Personal Care (Main): Silk fibroin peptides (molecular weight 500-30,000 Da) are used in anti-aging and repair products; silk amino acids (<500 Da) enhance moisturizing and barrier function.

Other Innovative Applications

Functional Materials: Development of piezoelectric microchips, smart medical plaster, and 4D-printed shape memory materials.

Biomedicine: Used in tissue engineering scaffolds (such as tendon repair), drug delivery carriers, surgical sutures, and artificial skin.

Yuantai Organic Bio is committed to providing customers with the highest-quality Pure silk fibroin bulk and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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