Bulk Ginkgo Extract

What is Bulk Ginkgo Extract？

Bulk Ginkgo extract is an active substance made from dried leaves of Ginkgo biloba L. through standardized extraction, concentration and drying. Its chemical composition is complex, containing more than 30 active ingredients, mainly divided into flavonoids, terpenoids and other ingredients: organic acids (such as ginkgolic acid), alkylphenols, phenolic acids, steroids and polyprenols, etc.

The core active components are ginkgo flavonoids (total content ≥24%) and ginkgo lactones (≥6%), which achieve multi-dimensional pharmacological effects through synergistic effects (such as flavonoids scavenging free radicals and lactones inhibiting platelet activation factor).

Main components of Bulk Ginkgo Extract

The main components include the following categories:

Flavonoids: This is one of the most important active ingredients in Ginkgo biloba extract, with antioxidant, anti-inflammatory and vascular protective effects. Flavonoids include flavonoids, flavonols and their glycosides, such as quercetin, kaempferol and isorhamnetin.

Terpenoid lactones: This type of ingredient, especially ginkgolide, is a unique ingredient in Ginkgo biloba extract, which has the effect of anti-platelet aggregation and improving blood circulation. Ginkgolides include ginkgolide A, B, C and bilobalide.

Phenolic acid compounds: Although the content is low, this type of ingredient, such as ginkgo phenolic acid, has certain pharmacological activity, which may be related to anti-inflammatory and antioxidant effects.

These ingredients together give Ginkgo biloba extract a variety of pharmacological effects, such as improving blood circulation, protecting the nervous system, anti-oxidation, etc., and are widely used in the auxiliary treatment of cardiovascular and cerebrovascular diseases, nervous system diseases, and memory and cognitive function improvement.

Main effects of Bulk Ginkgo Extract

Promote blood circulation

Improve blood fluidity:

Ginkgo extract can reduce blood viscosity and improve blood fluidity, thereby preventing thrombosis. It makes blood easier to flow in blood vessels by increasing red blood cell deformability and inhibiting platelet aggregation.

Dilate blood vessels:

The active ingredients in ginkgo extract can dilate blood vessels, increase blood flow, and improve blood circulation in the brain, heart and surrounding tissues. This is of great significance for the prevention and treatment of cerebrovascular diseases, coronary heart disease and peripheral vascular diseases.

Neuroprotection

Antioxidant effect:

Ginkgo extract is rich in antioxidants such as flavonoids and terpenoid lactones, which can scavenge free radicals, inhibit lipid peroxidation, and protect cell membranes from damage. This helps slow down the progression of neurodegenerative diseases and has a certain improvement effect on Alzheimer's disease and vascular dementia.

Improve brain function:

Ginkgo extract can increase cerebral blood flow, improve brain cell metabolism, and improve cognitive functions such as memory and attention. It has a certain therapeutic effect on acute and chronic cerebral dysfunction and its sequelae, such as sequelae of stroke and cognitive dysfunction.

Application Areas of Bulk Ginkgo Extract

Cosmetics field

Sunscreen products: Ginkgo leaf extract has a certain contribution to resisting long-wave dark spot effect ultraviolet rays and medium-wave erythema effect ultraviolet rays. It can be used as an auxiliary ingredient of sunscreen and added to sunscreen products to increase the sun protection index of the product.

Skin care products: Ginkgo leaf extract is added to skin care products to use its antioxidant and anti-inflammatory properties to help clean and protect the skin, provide deep nourishment, improve uneven skin tone, dullness and other problems, enhance skin elasticity and firmness, and delay skin aging.

Washing and care products: Applied in shampoo and conditioner, using its antibacterial and anti-inflammatory properties to help maintain scalp health, reduce dandruff and excessive oil secretion, and make hair healthier and brighter.

Food and health field

It can be added to beverages as a functional ingredient, using its antioxidant and blood circulation improvement effects to provide consumers with health benefits, such as relieving fatigue and enhancing immunity; or made into capsules, tablets and other health products to prevent and improve some health problems related to blood circulation, nervous system, etc., such as preventing cardiovascular and cerebrovascular diseases, improving memory, etc.

Medical field

Treat cardiovascular and cerebrovascular diseases, improve brain dysfunction, relieve ear and eye diseases, and improve peripheral circulation disorders, etc.

What are the indications for Ginkgo extract?

Improve memory and decline in cognitive function

With age, memory loss has become a concern for many people. Bulk Ginkgo extract can improve blood flow in tiny blood vessels in the brain, increase cerebral blood flow, and thus promote oxygen and nutrient supply to brain cells. In addition, Ginkgo biloba extract has an antioxidant effect, which can reduce the damage of free radicals to nerve cells and help maintain and improve memory function. Many studies have also shown that Ginkgo biloba extract has a certain effect in alleviating cognitive dysfunction, especially in the elderly.

Effect on insomnia

The active ingredients in Ginkgo biloba extract can relieve nervous tension caused by stress and anxiety, thereby promoting sleep. Of course, sleep can also be improved by improving work and rest. For example, establish regular sleep habits, create a good sleeping environment, avoid consuming irritating foods before going to bed, and perform moderate physical activities every day.

Help to relieve dizziness

Dizziness is often related to poor blood circulation in the brain. Ginkgo biloba extract helps relieve dizziness symptoms by improving blood circulation. The active ingredients, such as total flavonol glycosides and terpenoid lactones, can dilate blood vessels, increase cerebral blood flow, improve oxygen and nutrient supply, and thus reduce dizziness caused by insufficient blood supply. In addition, ginkgo leaf extract also protects nerve cells and can improve dizziness symptoms.

Diabetic eye disease and glaucoma

Diabetic patients are often at risk of multiple complications, such as diabetic retinopathy. Ginkgo leaf extract helps prevent these complications by improving microcirculation and reducing blood viscosity. Its antioxidant effect can also reduce adverse reactions caused by high blood sugar, protect the nervous and vascular systems, and slow the progression of complications. When using ginkgo leaf extract, diabetic patients should still monitor blood sugar regularly and combine hypoglycemic drugs to ensure comprehensive treatment effects.

Ginkgo flavonoids: a protective umbrella for blood and blood vessels

Whether it is ginkgo leaves or ginkgo nuts, the key to their function lies in the ginkgo flavonoids they contain. Ginkgo flavonoids, also known as ginkgo biflavonoids or ginkgo biflavonoids, are not a single component, but are composed of a variety of biflavonoid compounds with similar structures. These compounds are mainly found in the outer skin of ginkgo leaves and ginkgo nuts.

Flavonoids have antioxidant effects, protecting the body from free radicals and unstable molecules, which can damage body tissues and healthy cells and make people more susceptible to illness. The causes of free radicals may come from gene mutations, diseases, aging or environmental pollution, so antioxidants can prevent the formation of free radicals and make the body healthier.

Human effects of ginkgo flavonoids

·Inhibit platelet aggregation

Ginkgo flavonoids have a good inhibitory effect on ADP and collagen-induced platelet aggregation, and also inhibit collagen-induced platelet deformation and slow down the maximum aggregation of platelets, thereby achieving the effect of inhibiting thrombosis.

·Regulate blood lipids

Ginkgo flavonoids can significantly increase high-density lipoprotein, counteract platelet activation factor, reduce blood viscosity, plasma cholesterol, fibrinogen, improve the ratio of plasma cholesterol and phospholipids, and at the same time reduce the adverse effects of blood cholesterol, triglycerides, and very low-density lipoprotein on the human body, reduce blood lipids, improve microcirculation, and inhibit coagulation. These have significant effects on the prevention and treatment of hypertension.

·Effects on blood vessels

Quercetin, kaempferol and isorhamnetin all have the effects of dilating blood vessels and relieving spasms. It can dilate coronary blood vessels and increase blood flow in the uterus. Experiments have confirmed that the main component of ginkgo extract that causes vasodilation is quercetin, which can promote the increase of calcium ion concentration in vascular endothelial cells, promote NO synthesis and release, and cause vasodilation.

·Improves brain circulation and protects the brain

Ginkgo flavonoids can effectively reduce cerebral vascular resistance, improve cerebral circulation, increase cerebral blood flow, improve brain nutrition, help improve memory and brain dysfunction or age-related central nervous system dysfunction, and protect the brain and blood-brain barrier.

·Antioxidant effect

Ginkgo flavonoids can exert antioxidant properties in the brain, retina and cardiovascular system. Its antioxidant effect in the brain and central nervous system can help prevent brain function decline caused by age. The brain and central nervous system are particularly vulnerable to free radical attacks, and free radical-induced brain damage is widely believed to be a factor in the development of various diseases associated with aging, including Alzheimer's disease.

·Anti-atherosclerotic effect

Ginkgo flavonoids have a protective effect on human cytomegalovirus (HCMV) infection in promoting the occurrence and development of atherosclerosis. It has a certain preventive and therapeutic effect on atherosclerosis.

·Blood sugar regulation effect

Medically, there are drugs that use ginkgo flavonoid extracts instead of insulin for diabetic patients, indicating that ginkgo has the function of regulating blood sugar as insulin. Many glucose tolerance tests have proved that ginkgo extracts have obvious effects on regulating blood sugar, improving insulin resistance, thereby reducing insulin antibodies and enhancing insulin sensitivity.

Extraction methods of flavonoids from ginkgo leaves

The main extraction methods include solvent extraction, supercritical fluid extraction (SFE), high-speed countercurrent chromatography, microwave extraction, ultrasonic extraction, enzyme extraction, molecular imprinting technology, and fermentation.

In production, the traditional extraction process of ginkgo flavonoids mainly adopts solvent extraction, which is the oldest and lowest-cost extraction method. This method usually uses ethanol solution, acetone aqueous solution or sodium hydroxide aqueous solution as the extraction solvent. First, a crude extraction is performed, and then the flavonoid extract is obtained through refining steps such as defatting and removal of ginkgo phenolic acid. However, this method has obvious limitations, mainly manifested in the long extraction time and the risk of organic solvent residues. Taking 60% ethanol solution as an example, under the extraction condition of 80°C, it takes at least three hours to achieve the maximum extraction rate. If the subsequent refining process is considered, when processing large batches of samples, the entire process takes longer, which will significantly affect the research efficiency and production efficiency. In addition, this method also faces the problem that solvent residues may affect the purity and safety of the product. These defects have prompted researchers to continuously explore more efficient extraction technologies.

Recommended use

The daily intake of ginkgo flavonoids needs to be adjusted according to the purpose and individual situation. Generally, 120-240 mg per day is recommended. The specific dosage needs to be combined with health status and used under the guidance of a doctor.

·Precautions

Individual differences:

Age, weight, metabolic capacity, etc. all affect tolerance. It is recommended that the elderly or those with weak constitutions start with a lower dose and gradually increase.

·Drug interactions

Ginkgo may enhance the effects of anticoagulants and antiplatelet drugs and increase the risk of bleeding. If you are taking such drugs, you need to strictly follow the doctor's advice to adjust the dose.

·Long-term use

When taking it continuously for more than 6 weeks, it is recommended to regularly evaluate the effect and safety to avoid cumulative side effects.

·Applicable and contraindicated groups

     Suitable for the population:

• Middle-aged and elderly groups, mental workers, and those with mild poor blood circulation can use it under the guidance of a doctor.

Contraindicated groups:

• Pregnant women and lactating women: may affect coagulation function or fetal development
• Epilepsy patients: may reduce the efficacy of anti-epileptic drugs
• People within 2 weeks before surgery: increase the risk of intraoperative bleeding

As a professional bulk ginkgo extract manufacturer, YTBIO is committed to providing you with the highest quality bulk ginkgo extract powder and services, so that every consumer can enjoy natural, healthy and high-quality food. If you have any questions or needs about our products, please feel free to contact us at sales@sxytorganic.com and we will respond to you as soon as possible.