Dihydromyricetin Powder

Natural Dihydromyricetin/DHM Powder Supplier

Dihydromyricetin Powder (DHM), primarily extracted from plants such as Ampelopsis grossedentata, is a flavonoid compound with various bioactivities including antioxidant, hepatoprotective, hangover-relieving, and anti-inflammatory properties. In applications, DHM is widely used in liver-protective dietary supplements, metabolic health products, sports nutrition, functional foods, and anti-inflammatory and antioxidant skincare products.

YTBIO supplies dihydromyricetin with a purity ≥98%, using the leaves and stems of Ampelopsis grossedentata as raw material, and exhibiting good water solubility. We support small-sample testing and flexible MOQs, providing high-purity, high-activity dihydromyricetin raw materials for your health and functional food products.

Why Choose YTBIO?

Quality Control: From raw materials to finished products, every batch undergoes rigorous quality inspection.

Production Technology: Standardized extraction and purification processes maintain product stability and active ingredients.

OEM/ODM Services: We can provide customized formulation, packaging, labeling, and specification services according to your needs.

Export Experience: YTBIO has 12 years of experience in the plant extract industry, serving customers worldwide.

Stable Supply: With our own 10,000 square meter factory, we have stable supply and production capabilities.

Test Report

What are the Benefits?

1. Antibacterial Effects

Dihydromyricetin powder has significant inhibitory effects on cocci, bacilli, Gram-positive bacteria, and Gram-negative bacteria, and also has some inhibitory effects on yeasts and molds.

2. Regulating Blood Sugar and Lipids

Dihydromyricetin can significantly enhance the body's antioxidant capacity, inhibit hyperlipidemia, and has the effect of lowering blood sugar and improving insulin sensitivity in various diabetic patients.

3. Hepatoprotective Effects

Dihydromyricetin has significant protective effects against rat hepatocytes damaged by carbon tetrachloride poisoning, and against liver damage induced by D2-galactosamine and lipopolysaccharide in mice.

4. Antioxidant Effects

As a natural antioxidant, dihydromyricetin has the same structure as tert-butylhydroquinone (TBHQ). As one of the internationally recognized food antioxidants, dihydromyricetin extract has been widely used in oil paintings and oil-containing foods in dozens of countries and regions. It effectively and rapidly replaces traditional antioxidants. Under similar conditions, dihydromyricetin can be used below 220℃. Its effective concentration in peanut oil is 0.04%, and when added at half the amount of dihydromyricetin, its effect is superior to vitamin C (VC).

Relevant Experimental Data

1. Protective Effect of Dihydromyricetin on Intestinal Injury

In vitro experiments: Using rat small intestinal crypt epithelial cells as a model, different concentrations of AFB1 and DHM were applied. Results showed that AFB1 concentration-dependently reduced cell viability; DHM reversed the downregulation of tight junction proteins induced by AFB1, inhibited Nrf2/HO-1 signaling pathway activation, reduced the expression of calpain I, Bax, and inflammatory factors, while increasing Bcl-2 levels.

In vivo experiments: BALB/c mice were continuously administered AFB1 (200 μg/kg) and different doses of DHM (100, 200 mg/kg) by gavage for 30 days. Results indicated that AFB1 led to decreased small intestinal villus height and crypt depth, reduced tight junction proteins, abnormal Nrf2/HO-1 pathway, imbalance of apoptosis-related proteins, increased inflammatory factors, and decreased intestinal flora diversity. DHM intervention significantly improved all of these indicators.

Conclusion: Dihydromyricetin alleviates aflatoxin B1-induced intestinal damage by activating the Nrf2/HO-1 signaling pathway, enhancing intestinal barrier function, inhibiting apoptosis and inflammatory responses, and remodeling the intestinal flora structure.

Reference:Zhu X Y, Liu S L, Tang Y J, et al. Dihydromyricetin attenuates aflatoxin B1-induced IEC-6 cell damage and intestinal damage in mice by activating the Nrf2/HO-1 signaling pathway and modulation of gut microbiota[J]. Journal of Functional Foods, 2025, 127: 106716. DOI:10.1016/j.jff.2025.106716.

2. Dihydromyricetin: A Natural Anti-Aging Agent

In March 2026, a team from Shanghai Jiao Tong University School of Medicine and others published a study in *Nature Communications*, discovering that dihydromyricetin possesses significant anti-aging activity through screening a natural product library.

Mechanism of Action: Dihydromyricetin can protect senescent fibroblasts from DNA damage and inhibit age-related secretory phenotypes. Proteomics analysis showed that its mechanism of action involves promoting the translocation of peroxidase 2 (PRDX2) into the cell nucleus, thereby enhancing the DNA repair capacity of senescent cells.

Animal Models:

Mouse Model: Dihydromyricetin can reduce the degree of tissue aging and alleviate age-related physiological functional decline.

Cancer Model: In anti-cancer treatment regimens, dihydromyricetin can enhance the effect of chemotherapy.

Alzheimer's Disease Model: Dihydromyricetin can clear amyloid-β protein plaques in senescent microglia and alleviate neurodegenerative symptoms.

Conclusion: Dihydromyricetin is a natural anti-aging agent with potential application value in the intervention of various age-related diseases such as cancer and Alzheimer's disease.

Reference:https://www.nature.com/articles/s41467-026-70302-9

Applications of Dihydromyricetin

1. Pharmaceutical Applications:

Dihydromyricetin is widely used in anti-inflammatory and analgesic preparations such as tablets, capsules, and granules.

2. Health Product Applications:

It has liver-protective and hangover-relieving effects. It accelerates the decomposition of acetaldehyde, a metabolite of ethanol. It is an antioxidant that scavenge free radicals.

3. Applications in the Feed Industry:

Dihydromyricetin has good antibacterial properties and is used in the feed industry to enhance the immunity of poultry and livestock, improve production performance, and improve meat quality.

We suggest the following health supplement formulation combinations for development:

·DHM + Milk Thistle Extract

·DHM + Kudzu Root Extract

·DHM + Glutathione

·DHM + Vitamin B Complex

·DHM + Electrolyte Formula, etc.

Contact Us

Looking for a reliable Dihydromyricetin Powder 98% supplier? Contact YTBIO for samples, specifications, and bulk pricing.

Tel:86-029-86478251 / 86-029-86119593
Whatsapp:8617782577059
Email:sales@sxytorganic.com

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