Natural Ferulic Acid

Do You Know About Natural Ferulic Acid?

Natural ferulic acid is a natural phenolic compound widely distributed in various plants and food ingredients. It is abundant in plants of the Apiaceae, Ranunculaceae, and Poaceae families. Common sources include traditional Chinese medicinal herbs such as asafoetida, angelica, chuanxiong, and cimicifuga, as well as grains such as oats, corn, and rye. In addition, fruits (such as rhubarb and walnuts), vegetables (such as spinach), and coffee also contain certain amounts of ferulic acid. Ferulic acid exists in two isomers, cis and trans, with the trans configuration being more common in nature, more widely studied and applied, and generally exhibiting higher biological activity. This compound possesses various physiological functions, including antioxidant, anti-inflammatory, anticoagulant, detoxifying, hepatoprotective, and immunomodulatory effects, thus showing broad application prospects in the pharmaceutical, cosmetic, and food industries.

YTBIO: Providing High-Quality natural ferulic acid and Services

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com

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Main Efficacy and Mechanism of Action of Natural Ferulic Acid

1. Antioxidant and Anti-aging

Natural ferulic acid effectively scavenge free radicals, inhibit lipid peroxidation and enzymes that produce free radicals, while enhancing the activity of antioxidant enzymes in the body. This helps reduce oxidative stress damage to cells, delay skin aging, reduce wrinkles and age spots, and combat various chronic diseases caused by oxidative stress.

2. Anti-inflammatory and Antibacterial

By inhibiting the activity of inflammatory factors (such as COX and LOX), ferulic acid can significantly reduce chronic inflammatory responses and has potential as an adjunct treatment for inflammatory diseases such as arthritis and atherosclerosis. Studies have also shown that it has a certain inhibitory effect on common pathogenic bacteria such as Escherichia coli and Staphylococcus aureus.

3. Cardiovascular Protection

Regulating blood lipids: It can lower serum total cholesterol and low-density lipoprotein levels, reduce lipid deposition on blood vessel walls, and improve hyperlipidemia.

Protecting blood vessels: It has the effect of dilating blood vessels and improving vascular endothelial function, which helps to control blood pressure and prevent arteriosclerosis.

4.Antithrombotic Effects

By inhibiting platelet aggregation, blocking the activity of thromboxane synthase, and reducing the release of substances such as serotonin, ferulic acid effectively prevents thrombus formation.

5.Anti-radiation Effects

Studies have shown that ferulic acid can effectively inhibit radiation-induced DNA damage to peripheral leukocytes and bone marrow cells, protect the cell cycle from interference, and exert protective and repair effects on irradiated tissues by increasing the content of substances such as glutathione.

6.Improved Neurological and Memory Function

Ferulic acid can promote microcirculation, alleviate insufficient cerebral blood supply and related symptoms, and has an improving effect on diabetic peripheral neuropathy. Furthermore, it has a positive significance for the recovery and improvement of memory function in the elderly.

7.Other Effects

Ferulic acid also shows certain application potential in preventing bone loss and alleviating menopausal syndrome in women.

Three Major Application Areas of Natural Ferulic Acid

Cosmetics

Natural ferulic acid is highly favored by high-end cosmetic brands due to its outstanding skincare benefits:

Powerful Antioxidant: Its molecular structure effectively inhibits the generation of reactive oxygen species (ROS), scavenges free radicals, and protects the skin from oxidative damage.

Whitening and Spot Reduction: By inhibiting tyrosinase activity, it reduces melanin production at the source, achieving a whitening effect.

Natural Sunscreen: It has excellent UV absorption capabilities in the 290-330 nm wavelength range, providing natural sun protection.

Anti-aging and Firming: Known as an "intercellular adhesive," it promotes the growth of intercellular polysaccharides, enhances skin firmness, thereby reducing wrinkles and combating sagging.

Food Industry

As a safe and highly effective natural additive, ferulic acid plays multiple roles in the food industry:

Highly Effective Antioxidant: It has been approved as a food antioxidant in Japan and Europe. Research and practice have proven that combining it (e.g., 75 mg/kg) with sodium isovitamin c can effectively inhibit oil oxidation, reduce nitrite residues in meat products such as sausages, and maintain the original sensory quality of the products.

Natural cross-linking agent: It can safely and harmlessly cross-link proteins and polysaccharides, improving the structure and properties of food materials. For example, when used to modify collagen-chitosan composite films, it can significantly enhance their mechanical strength and reduce water vapor permeability, increasing the application value of food packaging materials.

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Pharmaceutical field

With its multiple biological activities such as antioxidant, anti-inflammatory, anti-radiation, and immune-enhancing properties, ferulic acid has become an important raw material for modern drug development. Specific derivatives have been formulated into various preparations for clinical use:

Cardiovascular and cerebrovascular diseases: For example, sodium ferulate injection is used to treat ischemic cardiovascular and cerebrovascular diseases; piperazine ferulate tablets can alleviate hypercoagulable states and are used as adjunctive therapy for glomerular diseases.

Raw materials for traditional Chinese medicine: Natural ferulic acid is used as the core ingredient and is widely used in traditional Chinese medicines such as Xinxuekang and Limai capsules to treat cardiovascular and cerebrovascular diseases and leukopenia.

Natural Ferulic Acid: Experimental Support for Multiple Efficacy

Antioxidant Effects

1. Clear Mechanism, Synergistic Effects

Studies have confirmed its multi-faceted antioxidant pathways: it not only directly scavenge free radicals but also effectively inhibits lipid peroxidation and reduces free radical generation at its source by chelating metal ions.

2. Activates the Intrinsic Defense System

In vitro and in vivo experiments show that ferulic acid can significantly enhance the body's total antioxidant capacity (TAC) and increase the activity of key antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), thereby systematically strengthening the body's own defenses.

3. Evidence from Both In Vitro and In Vitro Applications

Oral Efficacy: Clinical data show that daily oral administration of 200mg of ferulic acid for two weeks can significantly reduce transdermal water loss and improve skin moisturizing ability, confirming its skin-care effects through in vivo circulation.

Long-Lasting Effect: Compared with vitamin C, ferulic acid has a longer duration of action in the body, providing more sustained antioxidant defense, suitable for dealing with chronic or continuous oxidative stress.

Dual Protection Against Light Radiation

1. Enhanced Sunscreen Performance

Its cinnamic acid structure can directly absorb 290-320nm ultraviolet rays.

Combined with 1% ferulic acid, it significantly improves the efficacy of sunscreen products: SPF +37%, PA +26% (confirmed by a 2018 study).

It also possesses antioxidant properties, neutralizing photo-induced free radicals, making it safer than traditional sunscreens.

2. Anti-Radiation Damage

By activating the Nrf2 cellular defense pathway,

it effectively reduces cell apoptosis and DNA damage caused by ionizing radiation.

It provides cellular-level protection against low-dose radiation exposure.

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Ferulic acid improved IR-induced morphological changes in rat lens

Natural Anti-inflammatory Ingredients

1. Powerful Anti-inflammatory with a Clear Mechanism

Ferulic acid directly inhibits the gene expression of cyclooxygenase-2 (COX-2), reducing the production of inflammatory mediators such as prostaglandins at the source. Its mechanism of action is similar to that of nonsteroidal anti-inflammatory drugs (NSAIDs), demonstrating a clear anti-inflammatory pathway.

2. Multi-target Inhibition of Inflammatory Mediators

It effectively reduces the levels of multiple key inflammatory factors, including prostaglandin PEG2 and tumor necrosis factor-α (TNF-α), and inhibits the synthesis of inflammasomes in skin cells, thereby significantly alleviating skin inflammation and damage caused by external stimuli (such as ultraviolet radiation and pollution).

3. Drug-like Efficacy

In vitro studies have shown that ferulic acid's effect in inhibiting key pro-inflammatory factors is comparable to that of potent glucocorticoids (such as dexamethasone), providing direct evidence for its potent anti-inflammatory capabilities.

4. Synergistic Antioxidant and Anti-inflammatory Effects

Its anti-inflammatory efficacy is closely related to its powerful antioxidant effect, effectively intervening in inflammatory signaling pathways closely related to oxidative stress, achieving synergistic relief of chronic inflammation.

Multi-target Whitening Effect

Existing research indicates that ferulic acid possesses clear whitening potential, but its overall effect still lags behind top whitening ingredients; therefore, it is objectively described as having "a certain whitening effect."

Its mechanism of action is not singular, but rather involves multi-target intervention in the melanin synthesis pathway:

Inhibition of core enzyme activity: It can directly inhibit the activity of tyrosinase, a key enzyme in the melanin production process.

Regulation of upstream key factors: Studies have confirmed that ferulic acid can inhibit the expression of microphthalmia-associated transcription factor (MITF) at the protein level. MITF is the "master switch" regulating melanocyte synthesis activity; intervention from a more upstream perspective theoretically can produce a deeper whitening effect.

These findings provide a scientific basis for the application of ferulic acid as an auxiliary ingredient in whitening products.

FAQ：

Q: What specifications and sources of ferulic acid raw materials does YTBIO offer?

A: We mainly offer two types of high-purity ferulic acid:

Natural ferulic acid: derived from rice bran, purity ≥98%, conforming to the trend of natural products.

Synthetic ferulic acid: purity up to 99%, suitable for applications with higher requirements for cost and control.

Both meet stringent international quality standards.

Q: What are the core benefits of ferulic acid?

A: Ferulic acid is a multifunctional natural phenolic acid. Its core benefits include:

Powerful antioxidant: providing long-lasting antioxidant protection through multiple mechanisms such as scavenging free radicals and inhibiting lipid peroxidation.

Anti-inflammatory and soothing: effectively inhibiting inflammatory factors (such as COX-2 and TNF-α), reducing inflammatory responses.

Photoprotection and anti-radiation: naturally absorbs ultraviolet rays and can reduce radiation damage by activating cellular defense pathways (such as Nrf2).

Skin whitening aid: intervenes in melanin production through multiple targets by inhibiting tyrosinase and its upstream regulator MITF.

Q: How is the quality and compliance of YTBIO ferulic acid?

A: Our production system is fully certified, ensuring product safety, reliability, and compliance. Certifications include: cGMP, ISO22000, ISO9001, BRC, and HACCP. We also hold EU & NOP organic certificates, Kosher and Halal certifications, meeting the stringent requirements of different markets and customer groups worldwide.

Q: What are the benefits of combining ferulic acid in formulations?

A: Ferulic acid is a recognized "golden ingredient," offering significant advantages when combined with other ingredients:

In sun protection: Studies have shown that adding 1% ferulic acid can significantly improve the SPF and PA values ​​of a formulation.

In antioxidant applications: When used in combination with classic antioxidants such as Vitamin C and Vitamin E, it produces a synergistic effect and provides longer-lasting antioxidant protection.

Q: Can you provide samples?

A: Of course. We are happy to provide you with free samples so you can evaluate the quality of our products. Samples are free, but you will be responsible for the shipping costs.

Q: How do I place an order and pay?

A: After your order is confirmed, we will first send you a pro forma invoice containing our bank details. We accept payment via various convenient methods, including wire transfer, Western Union, PayPal, or third-party guaranteed transactions.

Q: What is the delivery time? How is logistics handled?

A: After receiving payment, we typically prepare and ship your product within 5-8 business days. We can arrange ocean freight, air freight, or international express delivery based on your needs. We work with trusted logistics partners to ensure safe and timely delivery of your goods to your designated port or address.

Q: How do I get started with YTBIO?

A: We are eager to collaborate with major global brands and partners. Please visit the YTBIO official website and submit your specific requirements through the "Contact Us" page. Our professional team will promptly provide you with detailed product technical documents (TDS), certifications (COA), and competitive solutions.

References

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【2】Zduńska K, Dana A, Kolodziejczak A, Rotsztejn H. Antioxidant Properties of Ferulic Acid and Its Possible Application. Skin Pharmacol Physiol. 2018;31(6):332-336. doi: 10.1159/000491755. Epub 2018 Sep 20. PMID: 30235459.

【3】Suzuki A, Nomura T, Jokura H, Kitamura N, Fujii A, Hase T. Beneficial effects of oral supplementation with ferulic acid, a plant phenolic compound, on the human skin barrier in healthy men. Int J Vitam Nutr Res. 2023 Feb;93(1):54-60. doi: 10.1024/0300-9831/a000699. Epub 2021 May 11. PMID: 33973806.

【4】Staniforth V, Huang W, Aravindaram K, Yang N: Ferulic acid, a phenolic phytochemi- cal, inhibits UVB-induced matrix metallo-proteinases in mouse skin via posttranslation- al mechanisms. J Nutr Biochem 2012;23:443– 451.

【5】Karsili TN, Marchetti B, Ashfold MN, Domcke W. Ab initio study of potential ultrafast internal conversion routes in oxybenzone, caffeic acid, and ferulic acid: implications for sunscreens. J Phys Chem A. 2014 Dec 26;118(51):11999-2010. doi: 10.1021/jp507282d. Epub 2014 Aug 25. PMID: 25137024.

【6】D’Almeida P D, Daud S F, Areias D O C, et al. Ferulic acid photoprotective properties in association with UV filters: multifunctional sunscreen with improved SPF and UVA-PF ［J］. Journal of Photochemistry & Photobiology B Biology, 2018, 185: 46-49.

【7】Chen Y, Shen J, Zhang X, Gao W, Cao Q, Yan F, Xue C. Protective effects of ferulic acid against ionizing radiation-induced oxidative damage in rat lens through activating Nrf2 signal pathway. Int J Ophthalmol. 2023 May 18;16(5):687-693. doi: 10.18240/ijo.2023.05.03. PMID: 37206165; PMCID: PMC10172089.

【8】Huang Congshu. Preliminary study on the effect of ferulic acid on radiation-induced skin injury ［D］. Guangzhou: Guangdong Pharmaceutical University, 2021.

【9】Chen Y, Zhu L, Meng H, Sun X, Xue C. Ferulic Acid Protects Human Lens Epithelial Cells against Ionizing Radiation-Induced Oxidative Damage by Activating Nrf2/HO-1 Signal Pathway. Oxid Med Cell Longev. 2022 May 10;2022:6932188.

【10】Hirata A, Murakami Y, Atsumi T, Shoji M, Ogiwara T, Shibuya K, Ito S, Yokoe I, Fujisawa S. Ferulic acid dimer inhibits lipopolysaccharide-stimulated cyclooxygenase-2 expression in macrophages. In Vivo. 2005 Sep-Oct;19(5):849-53. PMID: 16097437.

【11】Hosoda A., Ozaki Y., Kashiwada A., Mutoh M., Wakabayashi K., Mizuno K., Nomura E., Taniguchi H. Synthesis of ferulic acid derivatives and their Suppressive effects on cyclooxygenase-2 promoter activity. Bioorg. Med. Chem. 2002;10:1189–1196.

【12】Sakai S., Ochiai H., Nakajima K., Terasawa K. Inhibitory effect of ferulic acid on macrophage inflammatory protein-2 production in a murine macrophage cell line, Raw 264.7. cytokine. 1997;9:242–248.

【13】Oxidation of ferulic acid by momordica charantia peroxidase and related anti-inflammation activity changes.

【14】Park H J, Cho J H, Hong S H, et al. Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells ［J］. Journal of Natural Medicines, 2018.