Urolithin A Powder

Do You Know What Urolithin A Powder Is?

Urolithin A powder (UA), also known as "Natural Anti-Aging Ruby," is an endogenous substance produced by intestinal microbial metabolism after the human body consumes foods rich in ellagic acid or ellagitannins, such as pomegranates, strawberries, and nuts. It exhibits anti-inflammatory, antiproliferative, and antioxidant properties. It can be used as an organic synthesis, biochemical intermediate, and cell biological reagent. It can be applied to the modification and derivatization of pharmaceutical and bioactive molecules and is also widely used in health supplements.

YTBIO: Providing High-Quality Urolithin A Powder and Services

High-quality nutritional supplements are crucial to your health journey. YTBIO specializes in providing high-quality Urolithin A powder.

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com

Mechanism Of Action Of Urolithin A Powder

The core function of Urolithin A powder is closely related to mitochondrial autophagy. It activates the process of clearing aging or damaged mitochondria, thereby maintaining cellular energy metabolism efficiency. Furthermore, it reduces inflammation by inhibiting the NF-κB pathway and enhances the activity of antioxidant enzymes (such as superoxide dismutase), reducing free radical damage to cells.

Different Urolithin Forms

Urolithins A and B are both compounds produced by the gut microbiome through the metabolism of ellagitannins found in plants and are commonly found in pomegranates, berries, and nuts. Despite their structural similarities, some differences exist.

Biological Activity

Urolithin A: Known for its ability to promote mitophagy, which helps clear damaged mitochondria and improve cellular energy metabolism. It also exhibits strong antioxidant and anti-inflammatory properties.

Urolithin B: While also possessing anti-inflammatory properties, its role in promoting mitochondrial health is relatively less studied, with more attention focused on its potential to improve muscle function.

Applications

Urolithin A: Extensively studied in anti-aging, exercise recovery, and chronic disease prevention, it is believed to benefit cellular health and overall metabolism.

Urolithin B: Research has focused more on muscle health and inflammatory disorders, particularly showing potential in improving muscle atrophy and function.

What Are The Main Benefits Of Urolithin A Powder?

Anti-Aging

By promoting mitochondrial autophagy, it improves cellular energy metabolism and slows cellular aging, particularly for maintaining healthy muscle tissue. Animal studies have shown that Urolithin A can extend the lifespan of nematodes by approximately 45% and improve muscle function in aged mice. Its ability to promote mitochondrial renewal may slow age-related functional decline.

Muscle Health

It may help reduce exercise-induced muscle damage, promote recovery, and enhance athletic performance, providing a beneficial effect for athletes and fitness enthusiasts. Clinical trials have found that supplementing with Urolithin A can improve muscle endurance in middle-aged and elderly individuals and reduce post-exercise lactate accumulation, possibly through improved mitochondrial function.

Disease Prevention

Its antioxidant and anti-inflammatory properties may be beneficial in the prevention and adjunctive treatment of chronic diseases such as cardiovascular disease, metabolic syndrome, and neurodegenerative diseases.

Metabolic Regulation: Preliminary studies suggest that it may improve insulin sensitivity and reduce fat accumulation in models of obesity.

Skin Care

Anti-Wrinkle and Moisturizing: Topical application can reduce wrinkle depth, enhance skin hydration, and inhibit collagen degradation.

UV Protection: Protects skin from UV damage.

The Multi-Dimensional Effects Of Urolithin A Powder

Urolithin A powder has become a popular anti-aging product. Ellagic acid (the precursor of urolithin A) can help alleviate oxidative stress and neuroinflammation, thereby improving cognitive impairment in elderly patients. Urolithin A itself also acts as a senomorphic modulator, blocking the infection of surrounding cells by senescent cells.

Research has found that urolithin A has dual anti-aging mechanisms: Urolithin A inhibits the secretion of senescence-promoting agents (SASPs) by senescent cells, thereby blocking the spread of senescence signals. Secondly, urolithin A inhibits the secretion of molecules related to damage-causing "alarmins," known as DAMPs, reducing nuclear and mitochondrial DNA leakage, and targeting the cGAS-STING signaling pathway to alleviate inflammation.

Urolithin A was actually discovered as early as 2005. In a 2016 blockbuster study published in the leading medical journal Nature Medicine, urolithin A was shown to extend the lifespan of nematodes by 45% and improve the endurance of mice by 57%. Since then, the use of urolithin A in anti-aging has become increasingly widespread. Its effectiveness has been demonstrated in numerous species, including nematodes, fruit flies, mice, killifish, and humans, with anti-aging benefits for the intestines, muscles, brain, joints, hearing, and other organ systems.

Urolithin A powder is the first natural anti-aging substance recognized by the scientific community as promoting mitochondrial autophagy. Simply put, it promotes cellular waste removal while recycling useful components, maintaining a youthful appearance. Urolithin A also combats oxidative damage and reduces inflammation through multiple mechanisms: it activates the Nrf2 antioxidant pathway and inhibits the NF-κB inflammatory pathway, enhancing cellular defenses. It also inhibits the synthesis and release of key inflammatory factors and the activity of enzymes that produce reactive oxygen species, providing anti-oxidant and anti-inflammatory benefits from within.

With such highly effective and widely applicable functions as promoting autophagy and anti-oxidant and anti-inflammatory properties, what are the practical benefits of urolithin A for our bodies?

Regulating the body's microbiome and aiding weight loss

Urolithin A can induce the activation of metabolically active brown fat, promoting the conversion of white fat into brown fat. This can prevent fat accumulation caused by inappropriate dietary habits and improve cellular lipid metabolism. In a clinical trial, researchers added California strawberry powder, rich in the precursor of urolithin A, to the diet of healthy subjects. The subjects experienced significant weight loss and also experienced an increase in the abundance and robustness of beneficial gut bacteria associated with longevity. In Japan, urolithin A and its metabolic precursor, ellagitannins, are widely added to various functional foods and health supplements, making them popular ingredients in the Japanese weight loss market.

Slowing Muscle Loss

Urolithin A can also slow aging-related muscle loss and enhance athletic performance. In a human clinical trial, 88 middle-aged Canadians aged 40 to 64 were randomly assigned to receive either 500mg or 1000mg of urolithin A daily supplementation. After four months, the subjects experienced a 12% increase in muscle strength and improved athletic performance. Participants, simply continuing their daily exercise routine, saw significant improvements in muscle strength and athletic performance, demonstrating that urolithin A can provide tangible health benefits for our physical vitality.

Improving Wrinkles and Anti-Aging Skin

In one study, researchers added 0.5% and 1% urolithin A to skincare products and gave them to participants. Results showed that the 1% urolithin A significantly improved wrinkles in just two weeks and effectively protected against UV damage. Further testing revealed that urolithin A also increased the levels of type I and type III collagen in the skin and reduced skin inflammation. Internal use of urolithin A can also prevent skin glycation, thereby improving signs of aging, such as yellowing, dullness, sagging, and wrinkles.

Urolithin A improves skin​​​​​​​

Bone and Joint Health

Urolithin A powder significantly improved mitochondrial respiration and autophagy in knee chondrocytes in patients with osteoarthritis. By improving mitochondrial health, it reduces cartilage degeneration and synovial inflammation, alleviating joint pain.

Preventing Alzheimer's Disease

UA can also reduce oxidative stress and the secretion of neuroinflammatory factors, helping to combat neurodegeneration and pathology induced by stress and aging. It has potential protective effects against neurodegenerative diseases such as Alzheimer's and Parkinson's.

While urolithin A supplements offer numerous benefits, obtaining the precursors through natural food sources is still the preferred method. Increase your daily intake of pomegranates and berries, and incorporate fiber-rich foods (such as whole grains and legumes) to maintain active intestinal flora. For those with weaker microbial metabolism, specific probiotics may help boost urolithin A production, but this should be done under professional guidance.

It's also important to note that urolithin A powder is not a panacea; its effectiveness must be integrated with a balanced diet and a healthy lifestyle.

YTBIO has own factory and R&D team, dedicated to providing you with high-quality urolithin A powder and services. If you have any questions or needs, please contact us and we will respond to you as soon as possible.