Coumarin Powder

What is Coumarin?

Coumarin Powder, also known as 1,2-benzopyrone, is an oxygen heterocyclic compound with a chemical formula of C9H6O2. It can be extracted from tonka beans (native to Guyana) or prepared by chemical synthesis. Coumarin is the parent nucleus of a large class of coumarin compounds found in plants. In addition to tonka beans, it is naturally found in many edible plants, such as strawberries, black currants, apricots and cherries, as well as herbs cinnamon or cassia seeds. It is an important spice, often used as a fixative, deodorant, and in the preparation of perfumes and spices. It is also used as a flavoring agent for beverages, foods, cigarettes, plastic products, rubber products, etc. It is used in medicine, spices, dyes, agriculture and other fields. In the field of medicine, coumarin and its derivatives have obvious biological activity, and have pharmacological effects on the human body such as anticoagulation, antibacterial, anti-inflammatory, antioxidant, hypoglycemic, anti-osteoporosis, and anti-hypertension.

Product Details Sheet

Product Name	Coumarin
CAS	91-64-5
EINECS	202-086-7
Chemical Formula	C9H6O2
Molecular Weight	146.143
Melting Point	68-73 °C (lit.)
Boiling Point	298 °C (lit.)
Density	0.935
Flash Point	162 °C
Storage Conditions	Store Below +30°C

Physiological functions

Enhance immunity
It helps to enhance the body's immunity and improve the ability to resist diseases.

Protect neural stem cells
It can protect neural stem cells from damage and help maintain the health of the nervous system.

Antioxidant
It can remove free radicals and reduce oxidative stress, thereby protecting cells from damage.

Anti-inflammatory
It helps to reduce inflammatory responses by inhibiting the release of inflammatory mediators, which is beneficial for alleviating inflammation-related diseases.

Anti-osteoporosis
It can inhibit the formation of osteoclasts through different mechanisms, thereby playing an anti-osteoporosis role.

Anti-coagulation
It can inhibit platelet aggregation, reduce blood viscosity, and help prevent thrombosis.

Regulate blood sugar
It can affect the secretion and action of insulin, and has a positive effect on maintaining blood sugar stability.

Cardiovascular and neuroprotection
It can improve endothelial function, alleviate changes in vascular morphology, and increase the plasma levels of nitric oxide metabolites and adiponectin, and has a regulatory effect on hypertension, dyslipidemia and insulin resistance.

Coumarin regulates SASP to inhibit cell senescence and relieve osteoarthritis (OA)

It is a family of naturally occurring phenolic compounds, which is composed of α-pyrone ring fused with benzene ring. Its family member, daphnetin, can inhibit the proliferation and inflammatory response of human immortalized keratinocytes.

Effect on the activity of C28/I2 chondrocytes

Effect on the mRNA expression level of aging-related markers in C28/I2 cells

Effect on the p38/MAPK14 pathway and the expression level of inflammatory factor-like SASP factors in C28/I2 cells

Effect on the expression level of protease-like SASP factors in C28/I2 cells

The results show that coumarin may regulate chondrocyte SASP through the p38/MAPK14 pathway, further alleviate the destruction of cartilage structure caused by aging, and thus achieve the purpose of treating osteoarthritis.

Applications

Food
As a flavor enhancer, it can be used to season candies, cakes and other foods to increase the flavor of the food. However, it should be noted that its use in food is strictly restricted because it is potentially toxic to the liver and kidneys.

Cosmetics and spices
Cosmetics: Due to its unique fragrance, it is often used as an additive in cosmetics and perfumes to enhance the attractiveness and sensory experience of the product.
Fixative: It can be used as a fixative to prepare perfumes and floral water essences, as well as a flavor enhancer for cigarettes, rubber products, plastic products, etc.

Medicine
It has anti-inflammatory, anti-coagulation and other biological activities, and can be used as a pharmaceutical raw material to treat related diseases.

Production Method

(1) Prepared by Perkin reaction of salicylaldehyde. This is the synthesis method first used by Perkin in 1868. Calcined potassium carbonate can be used as a catalyst for the reaction of salicylaldehyde and acetic anhydride. Carbonic acid and acetic anhydride are added to salicylaldehyde and heated to 187°C. Acetic acid is evaporated at a gas phase temperature of about 120°C, and then acetic anhydride is added to react at 210-212°C. The obtained coumarin crude product is washed with water and then vacuum distilled. It is then recrystallized from ethanol or isopropanol and dried at 50°C to obtain the finished product.
(2) The intermediate o-cresol phosphate is obtained by the reaction of o-cresol with phosphorus oxychloride, and then chlorinated at 180°C to convert the methyl group to -CHCI2, and then reacted with sodium acetate at 160-180°C for 5h for cyclization. If o-cresol reacts with phosgene, the process is completed via the intermediate o-cresol carbonate: o-cresol sodium salt reacts with phosgene at 60°C and 0.15MPa to form o-cresol carbonate. Chlorine is used to chlorinate the ester at 180-185°C to a chlorine content of about 37%, which is equivalent to two chlorine atoms on the side chain of each cresol. Finally, in the presence of pyridine or zinc oxide and cobalt oxide, condensation with acetic acid and acetic anhydride is performed to obtain coumarin, and the yield of this method is quite high.

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Coumarin Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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