Dipeptide-15

Dipeptide-15 (99%) | Supplier of High-Purity Cosmetic Raw Materials

YTBIO now offers high-purity (99%) Dipeptide-15 raw material with substantial stock available for immediate delivery. This product is suitable for use in a wide range of formulations designed to enhance skin and hair health, including serums, lyophilized powders, facial masks, lotions, hair and body care products, and various functional cosmetics.

What is Dipeptide-15?

Dipeptide-15—also known as Glycylglycine(Gly-Gly)/Diglycyl peptide—is formed by linking two glycine molecules via a peptide bond, making it one of the simplest dipeptides in structure. In recent years, this ingredient has garnered significant attention from brands, particularly for applications involving oil control, pore minimization, and the improvement of skin texture.

Product Details:

Ingredient Characteristics: Unlike traditional acidic ingredients, Glycylglycine is a bioactive peptide offering excellent affinity and compatibility. It features a simple molecular structure and good stability. Dipeptide-15 can be incorporated into both water-based and oil-based formulations, making it suitable for a wide range of skincare products. It is a low-irritation ingredient that is safe for use in products designed for sensitive skin.

Stability: Stable for extended periods at room temperature.

Recommended Dosage: 0.01–2.0% (cosmetics). 

Why Choose YTBIO?

• YTBIO has specialized in the production and export of cosmetic raw materials, plant extracts, and functional active ingredients for 12 years, operating a modern, company-owned factory spanning 10,000 m².​​​​​​​
• The company holds various international certifications, including cGMP, ISO9001, ISO22000, FSSC22000, BRC, Halal, and Kosher.
• We have established a comprehensive quality control system to ensure the purity, stability, and batch-to-batch consistency of every product. We provide COA, MSDS, TDS, testing reports, and formulation application advice.
• YTBIO offers high-purity (≥99%) Glycylglycine and maintains stable inventory levels to ensure prompt order response and reliable delivery.

What Is the Mechanism of Action of Dipeptide-15?

An excess of free fatty acids—particularly the accumulation of oleic acid—in sebum can induce abnormal changes in keratinocytes. An abnormal rise in intracellular Ca²⁺ concentration disrupts the keratinization process, compromising the structural integrity of the skin barrier and causing the tissue surrounding the pore edges to gradually slacken and dilate. This is the mechanism behind pore formation.

Research indicates that glycine receptors play a role in regulating cellular ion balance. As a glycine derivative, Diglycyl-peptide (Dipeptide-15) helps maintain cellular charge balance and improves enlarged pores caused by abnormal keratinization.

Therefore, Dipeptide-15 does not merely improve the appearance of pores through surface astringency; rather, it functions by regulating skin homeostasis.

Skincare Benefits

Improves Enlarged Pores

Glycylglycine helps maintain normal keratinization, resulting in refined, smooth skin and addressing issues like visible pores and rough texture.

Reduces Sebum Secretion

Studies indicate it participates in processes related to lipid metabolism, helping to reduce excessive skin oiliness.

Refines Skin Texture

It promotes epidermal turnover and evens out skin texture, leading to smoother skin.

Stabilizes the Skin Barrier

It helps address barrier issues caused by sebum imbalance, maintaining overall skin health.

Value in Hair Care

Beyond skincare, Dipeptide-15 is also effective in hair care. It enhances hair smoothness and manageability, leaving hair feeling soft, silky, and lightweight.

Recommended Applications

Pore Care: Suitable for pore-refining serums, toners, and freeze-dried essence products.

Oil Control:Ideal for oily skin care, men's grooming, and products for younger skin.

Anti-Aging:Can be used in firming, repairing, and rejuvenating skincare products.

Sensitive Skin Care:Suitable for soothing, repairing, and barrier-supporting products.

Premium Hair & Scalp Care:Suitable for scalp and hair nourishment products, including shampoos, conditioners, hair masks, scalp serums, and anti-frizz treatments.

International Application Examples

Glycylglycine has garnered sustained interest from renowned international skincare brands in recent years. For instance, Shiseido’s research team investigated the mechanisms behind enlarged pores and discovered that glycine derivatives are valuable for addressing abnormal keratinization and improving the appearance of pores. Based on these findings, glycylglycine has been incorporated into products designed for pore care and skin texture improvement.

In 2026, Shiseido’s open innovation program launched a high-concentration serum featuring glycylglycine as a key ingredient. By positioning it as a vital active ingredient for improving skin texture and pore care, the company further boosted market interest in this raw material within the functional skincare sector.

Production Process Development

Currently, industrial production of glycylglycine primarily relies on chemical synthesis, though enzymatic catalysis is increasingly becoming a focus of industry attention. The condensation of glycine to form diglycine (Dipeptide-15) is catalyzed by amino acid ligase under mild conditions with high selectivity.

In recent years, research has focused on enhancing conversion efficiency, reducing ATP consumption, and mitigating product inhibition, paving the way for the green production of diglycine.

Contact Us

If you are looking for a supplier of high-purity Dipeptide-15 powder (99%), please contact YTBIO to obtain the COA, specifications, samples, and formulation advice.

​Tel:86-029-86478251 / 86-029-86119593

Whatsapp:8617782577059

Email:sales@sxytorganic.com