Earthworm Extract

Do you know Earthworm Extract Lumbrukinase？

Earthworm Extract Lumbrukinase , also known as proteolytic enzyme, is an enzyme with proteolytic activity extracted from earthworms. It was first discovered in the intestines and body fluids of earthworms by Japanese scientists in 1982 and exhibits urokinase-like protease properties. Lumbrukinase's primary functions include directly degrading fibrin in the blood, activating plasminogen to plasmin, and accelerating the dissolution of blood clots. Earthworms (dilong) are one of the ingredients in the Four Insects formula of traditional Chinese medicine. Lumbrukinase is a plasmin isolated and purified from farmed earthworms. It has a stable structure, is absorbed by the small intestine, and is highly specific for fibrin. It can promote fibrinolysis through various pathways and is often used as an anti-thrombotic agent.

Mechanism of Lumbrokinase's Effect on Thrombosis

1. Dissolution

Multiple active enzyme molecules can smoothly enter the microvasculature, dissolve microthrombi within them, restore their elasticity, and thus relieve blockages.

2. Clearance

Clearing both fresh and old thrombi, it enhances the body's natural anticoagulant function and activates the differentiation of endothelial cells.

3. Reconstruction

Promotes microvascular regeneration, establishes collateral circulation, opens new blood pathways to the heart and brain tissues in the affected area, and repairs necrotic brain neurons.

YTBIO: Providing High-Quality Earthworm Extract and Services

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com

CERTIFICATE OF ANALYSIS

The Powerful Effects of Earthworm Extract Lumbrokinase

Earthworm Extract Lumbrokinase is known as the "vascular scavenger." Its superior thrombolytic efficacy and high safety make it an ideal choice for the prevention and adjunctive treatment of cardiovascular and cerebrovascular diseases.

Highly Effective Thrombolysis

Lumbrokinase has a thrombolytic capacity far exceeding that of urokinase, streptokinase, and nattokinase, and is effective against both newly formed and old clots.

Comprehensive Action: It not only hydrolyzes fibrin, which requires plasminogen, but also directly hydrolyzes fibrin particles that do not contain plasminogen, resulting in more thorough thrombolysis.

Targeted Tracking: Like a "scavenger," it tracks and dissolves microthrombi in the blood vessels, precisely targeting clots without disrupting normal coagulation mechanisms.

Anticoagulation and Thrombosis Prevention

Lumbrokinase dissolves existing clots while effectively preventing the formation of new ones, achieving a safe "dissolving and preventing" approach.

Inhibiting Platelet Aggregation: It reduces blood viscosity and inhibits excessive platelet adhesion and aggregation. It can specifically reduce plasma TXB2 levels in diabetic patients, fundamentally reducing the tendency to form clots.

Protecting Coagulation Balance: It is highly targeted, acting only on coagulation factors that have a tendency to aggregate, without causing bleeding risk. It has minimal adverse reactions and is well tolerated by patients.

Repairing Vascular Vessels

Lumbrokinase not only addresses thrombosis but also works to repair damaged blood vessels themselves, improving overall cardiovascular and cerebrovascular health.

Repairing Vascular Endothelium: It repairs damaged endothelial cells through open repair, increasing vascular elasticity and oxygen supply.

Improving Collateral Circulation: It strengthens cardiovascular and cerebrovascular collateral circulation, improves microcirculation, and has a proven effect on coronary heart disease, angina pectoris, cerebral infarction, and other conditions.

Activates the fibrinolytic system: Creates a long-term, stable anti-thrombotic environment in the body, significantly prolongs vascular occlusion, and allows blood vessels to regulate blood flow through their own elasticity.

Activates Cells

Earthworm Extract Lumbrokinase is a highly active proteolytic enzyme with powerful repair and activation effects on damaged tissue.

Rescue of Ischemic Cells: Repairs necrotic brain cells in the area surrounding a thrombus and rescues cells in a state of shock or semi-shock in the "penumbra," reducing brain tissue damage and significantly promoting recovery from cerebral thrombosis, sequelae of cerebral infarction, and myocardial infarction.

Enhances Cell Vitality: Activates human cells, enabling them to rapidly restore normal physiological function and biological activity, enhancing tissue vitality.

In addition, lumbrokinase has been shown to have the following multiple health benefits:

Assists in improving high blood pressure.

Helps restore vision problems caused by blocked eye vessels.

Increases antioxidant enzyme activity in the body, delaying aging.

Lowers cholesterol and triglyceride levels.

Applications of Lumbrokinase

Earthworm Extract Lumbrokinase has a wide range of clinical applications, primarily for the treatment and prevention of various thrombotic disorders, particularly those associated with elevated fibrinogen levels and platelet aggregation. It has significant regulatory effects on the following conditions:

Coronary heart disease: Improves heart blood flow and relieves angina symptoms.

Cerebral infarction: Dissolves cerebral clots and repairs damaged brain cells.

Diabetes: Regulates blood sugar and improves microcirculation.

Nephrotic syndrome: Reduces proteinuria and protects renal function.

Cor pulmonale: Improves pulmonary circulation and alleviates dyspnea.

Deep vein thrombosis: Dissolves clots and relieves limb swelling.

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Skincare Benefits

Lumbrukinase is a group of proteolytic enzymes extracted from a special species of earthworm. Long-term use improves skin. It is a safe and reliable skincare product with dual conditioning and beautifying properties, supporting skin metabolism and repair at various levels. It is non-irritating to the skin and not only protects the skin and improves rough skin, but also has a good anti-inflammatory effect on weight loss, freckles, post-inflammatory pigmentation, acne and facial eczema.

Other Kinases Related to Earthworm Extract Lumbrokinase

Urokinase, nattokinase, and lumbrokinase are three commonly mentioned thrombolytic agents in the fields of vascular health management and thrombosis prevention. Despite their similar names, they possess fundamental differences.

Urokinase: A Medical Agent for Acute Thrombolysis

Urokinase is a protease extracted from the urine of healthy individuals. It acts as an exogenous plasminogen activator, indirectly dissolving clots by activating the body's own plasminogen.

Its core characteristic is its potent but nonspecific nature. While highly effective in dissolving clots, it also indiscriminately degrades fibrinogen in the blood, impairing normal coagulation and posing a high risk of bleeding. Therefore, urokinase is strictly a prescription drug used only in early medical emergencies, with a very short window of efficacy, making it unsuitable for daily healthcare.

Nattokinase: A Safe Daily Choice

Nattokinase, derived from natto, a traditional Japanese fermented food, is a serine protease that acts directly on fibrin. It hydrolyzes the primary substrate of clots, achieving direct thrombolysis.

Its greatest advantage lies in its high degree of targeting and safety. It can specifically break down already formed blood clots without significantly affecting normal coagulation factors and fibrinogen in the blood, nor disrupting the physiological coagulation balance. Based on this characteristic, nattokinase is very suitable for long-term prevention and rehabilitation of cardiovascular and cerebrovascular diseases, as well as daily maintenance of vascular health.

YTBIO has own factory and R&D team, dedicated to providing you with high-quality  Earthworm Extract Lumbrokinase and services. If you have any questions or needs, please contact us and we will respond to you as soon as possible.

FAQ

Q: What certifications do you hold?

A: We prioritize product quality and safety, and our production facilities hold several top international certifications, including:

· cGMP

· ISO9001 and ISO22000

· BRC

· HACCP

· EU and NOP organic certifications

· Kosher certification

· Halal certification

Q: Do you provide third-party test reports (COAs) for your products?

A: Of course. We provide a COA with every batch.

Q: Do you offer custom products and technical support?

A: Yes, we have a strong R&D team. In addition to standard products, we can also provide customized dosage forms and customized packaging to meet your specific needs.

Our technical team is always ready to provide comprehensive technical support, including product application and formulation advice.