Eggshell Membrane Extract Powder

What Is Eggshell Membrane Extract Powder？

Eggshell membrane extract powder is a natural bioactive substance extracted from eggshell membrane, also known as eggshell membrane extract or phoenix coat extract. It is made from eggshells, and is made through processes such as shell membrane separation (discarding the shell), sterilization, hydrolysis, mixing, drying, grinding, etc., and is generally in powder form. It is mainly composed of keratin, collagen, hyaluronic acid, chondroitin sulfate, etc., and is rich in nutrients and bioactive molecules. Eggshell membrane extract has been used in various applications, such as food supplements, nutritional supplements and cosmetics.

Main ingredients

Protein: It is one of the main components of eggshell membrane extract, with a high content. It contains multiple types of collagen, such as type I, type V and type X collagen, and also contains 19 kinds of amino acids, with high content of proline, glycine and hydroxyproline.

Glycosaminoglycans: including chondroitin sulfate, hyaluronic acid, etc. These ingredients play an important role in joint health, skin moisturizing, etc.

Other ingredients: It also contains keratin, polypeptides, trace elements such as calcium, strontium, magnesium, phosphorus, and transport proteins.

Main Functions Of Eggshell Membrane Extract Powder

Relieve pain and stiffness: Contains collagen, chondroitin sulfate and other ingredients to stabilize joint structure, relieve osteoarthritis pain and stiffness, improve joint fluid viscoelasticity, reduce friction, and improve mobility.

Protect cartilage: Hyaluronic acid promotes cartilage regeneration, repairs worn cartilage, and prevents erosion of joint cartilage.

Anti-inflammatory and detumescence: Inhibits pro-inflammatory cytokines, reduces joint inflammation, and delays the progression of osteoarthritis.

2. Skin care

Promote collagen regeneration: Stimulates skin collagen production, enhances elasticity, and reduces wrinkles.

Moisturizing: Hyaluronic acid efficiently locks in moisture, maintains skin moisture, reduces water loss, and improves hydration.

Antioxidant: Removes free radicals, reduces oxidative damage, and delays skin aging.

3. Other effects

Enhance immunity: Lysozyme has antibacterial, antiviral, and anti-inflammatory properties, and strengthens immune defense.

Promote wound healing: Traditionally used to treat burns, ulcers, etc., modern research has confirmed its role in accelerating wound repair.

Main Applications Of Eggshell Membrane Extract Powder

Health products

As a core ingredient of dietary supplements, it fully supports joint health, skin repair and overall functional improvement.

Beauty industry

Added to facial masks and other skin care products, it provides triple effects of brightening skin tone, firming contours and barrier repair.

Agriculture

As a crop nutritional supplement, eggshell membrane extract significantly improves the yield and quality of agricultural products.

Can Eggshell Membrane Extract Relieve Joint Pain?

Eggshell membrane extract powder can promote the regeneration of joint cartilage, while improving stiff joints and relieving pain. How does it work?

The role of eggshell membrane extract in caring for joints

Relieve joint pain and stiffness

The collagen (type I, type V, type X), chondroitin sulfate, hyaluronic acid, and elastin in eggshell membrane extract can help relieve joint pain, improve the viscoelasticity of synovial fluid, reduce friction between bones, and make joint movement smoother. Studies have shown that after taking eggshell membrane for 30 days, patients with osteoarthritis with acute pain had a 51.9% reduction in joint pain, and the pain was reduced by more than 50% within 30 days.

Let the worn cartilage grow again

The hyaluronic acid in eggshell membrane extract is the key "guard" to protect joint cartilage.Hyaluronic acid is the main component of synovial fluid, secreted by synovial cells, fibroblasts and chondrocytes. It has multiple physiological functions such as regulating protein expression, assisting the diffusion and transport of water and electrolytes, and promoting wound healing. It plays an indispensable role in protecting joint cartilage.

Anti-inflammatory and detumescent effect

Eggshell membrane extract also performs well in anti-inflammatory aspects. Eggshell membrane extract can significantly inhibit proinflammatory cytokines in knee joint cartilage, which indicates that in the early stages of osteoarthritis, eggshell membrane extract can effectively reduce the inflammatory response by inhibiting the expression of proinflammatory cytokines and inflammatory mediators, thereby delaying the development of osteoarthritis and protecting the patient's joint health.

Increase tendon elasticity

The core principle of eggshell membrane to improve tendon elasticity is that it is rich in collagen, elastin and glycosaminoglycans, which can directly supplement the structural matrix of tendons, protect and repair tendon tissues. A study used eggshell membrane extract on elderly patients to observe whether it could improve the strength of Achilles tendon and knee joint muscles in the elderly. The results showed that after 50 days of ingestion of eggshell membrane, the tendon elasticity of the elderly increased by 46%, and the tendon elasticity of athletes increased by 37%.

The Potential Of Eggshell Membrane Extract About Transform Biomedicine

Eggshell membrane extracts have attracted increasing attention in the biomedical field due to their unique properties, versatility, and sustainability. It is a thin film-like structure that covers the inner surface of the eggshell, separating the egg white from the eggshell. Eggshell membrane extracts consist of a complex matrix of proteins, glycosaminoglycans, and minerals, which makes them highly biodegradable and biocompatible. Eggshell membrane extracts have been used in food supplements, nutraceuticals, and cosmetics. In addition to this, it also has great potential in translational biomedical applications such as wound healing and tissue engineering.

It is widely observed that the eggshell membrane is a protein-rich structure containing more than 500 different proteins and is a natural source of collagen, fibronectin, proteoglycans, glycoproteins, hyaluronic acid, and many amino acids such as arginine, glutamic acid, histidine, cystine, and proline, which are present in high concentrations. In addition to proteins and amino acids, CaCO3 is present in the eggshell membrane due to a certain degree of mineralization in the outer membrane. The close structural similarity of the eggshell membrane to the extracellular matrix (ECM) and a large number of biological components makes the eggshell membrane of great use in many applications in materials science and tissue engineering. Collagen is a key component of the eggshell membrane: however, collagen only accounts for 10% of the 80%–85% organic matrix contained in the ESM. Despite this, collagen fibrils are the main morphological component of the eggshell membrane. It provides the eggshell membrane with the necessary structural support and also acts as a scaffold for biomineralization. Collagen is used in tissue engineering and biomaterial formation.

Eggshell membranes provide a natural source of substances that are critical to tissue engineering and wound healing. For example, eggshell membranes are a natural source of collagen, as well as glucosamine and hyaluronic acid, substances that are important to the development and success of biomaterials. For example, collagen fibers act as a 3D scaffold that can combine to form a new matrix, provide anchoring for new cells through cell surface adhesion, and are biocompatible and biodegradable. In addition, type V collagen provides tremendous tensile strength and structural support to the new matrix. Eggshell membranes also contain fibronectin, which promotes cell adhesion in addition to an arginine-glycine-aspartate tripeptide glycoprotein motif. At the same time, fibronectin also promotes cell growth, migration, and repair, which plays a key role in wound healing and cell integration to ensure the success of the scaffold. In addition, osteopontin in eggshell membranes helps with tissue repair and remodeling, while also regulating cytokine release and macrophage recruitment.

Wound healing process

A study published in 2023 showed that eggshell membrane is able to support bone cell growth in vitro, thus proposing its use as a bone graft material. Other studies have shown the potential of eggshell membrane for cartilage regeneration, nerve regeneration, and other tissue engineering applications. Recently, researchers have explored the potential of eggshell membrane for drug delivery and as a platform for regenerative medicine. Studies have shown that eggshell membrane can be loaded with drugs and growth factors and used to deliver these drugs to target tissues. In addition, eggshell membrane has been used as a platform for cell transplantation, where cells are seeded onto the membrane and transplanted into the body to regenerate damaged tissue.

In addition to wound healing, eggshell membrane has been found to have anti-aging properties. Ohto-Fujita et al. demonstrated that applying dissolved eggshell membrane to mouse skin resulted in increased expression of genes encoding type III collagen, decorative proteoglycans, and MMP2, which resembled the microenvironment of young papillary dermal skin. In addition, the level of type III collagen increased, resulting in increased skin elasticity. Therefore, eggshell membrane may help prevent skin aging and maintain its healthy state. 

Nerve damage is a major challenge in healthcare and there is a lack of effective treatments. Eggshell membrane is a promising matrix for nerve regeneration due to its biocompatibility and high content of bioactive components. Farjah et al. developed a conduit made of eggshell membrane tubes to connect severed nerves and guide their regeneration. The structure was placed between the proximal and distal ends of the rat sciatic nerve. In vivo studies showed that eggshell membrane supported the regeneration of peripheral nerves. Moreover, further studies showed that eggshell membrane was not only able to promote nerve repair but also promoted functional improvement of injured sciatic nerves in rats. The eggshell membrane group regenerated more myelinated axons than the autologous transplant group at postoperative day 90. The regenerative capacity of native ESM (nESM) can be enhanced by combining lycopene or ibuprofen therapy, which has been shown to further accelerate functional recovery of the sciatic nerve.

In neurosurgery, it is important to protect brain tissue from the harmful effects of metallic microsurgical instruments. An experimental study by Gokyar et al. evaluated the effect of using raw eggshell membrane as a therapeutic intervention to protect exposed brain tissue. In their study, 13.3% of fresh bovine cadaver brains that were not covered with eggshell membrane had minimal damage, while the damage rate of brains without eggshell membrane was 60%. According to the results of the study, eggshell membrane has a good effect as a brain tissue protection material and is indispensable in neurosurgery.Studies have shown that eggshell membrane is an effective patch for the treatment of moderate to large traumatic tympanic membrane perforations (TMPs) in humans. TMPs are perforations of the tympanic membrane caused by infection or trauma. In clinical practice, most TMPs have a tendency to heal spontaneously. Nevertheless, for large perforations, spontaneous healing fails. Jung et al. evaluated the effect of eggshell membrane patches on the healing time of TMPs. A sterile disc of eggshell membrane patch moistened with saline was placed on the surface of the patient's perforation. After three months, healing time was significantly improved in patients who had the eggshell membrane patch applied compared with those who had the perforation edges repaired.

The structure of cranial nerves

The above description shows that eggshell membrane extract (ESM) shows broad application prospects in the biomedical field. It is rich in active ingredients such as collagen, hyaluronic acid, glycosaminoglycans, etc., and has excellent biocompatibility and degradability. ESM can promote wound healing, accelerate nerve regeneration, and effectively protect brain tissue from surgical damage. In the field of orthopedics, ESM can be used as a bone transplant scaffold to support cell growth; in otology, its patch significantly shortens the healing time of tympanic membrane perforation. In addition, ESM can enhance skin elasticity, has anti-aging potential, and can be used as a drug carrier for targeted delivery of growth factors. These characteristics make it an ideal natural material for tissue engineering and regenerative medicine, and it is expected to play a greater role in clinical treatment in the future.

Who Are The Applicable Populations Of Eggshell Membrane Extract Powder?

Patients with joint pain or osteoarthritis: knee pain, chronic arthritis, limited mobility, chronic pain. Eggshell membrane extract can help relieve pain and inflammation.

People over 50 years old: Glucosamine and collagen in joints decrease with age, and joints frequently have various problems. Eggshell membrane extract can more easily nourish joints and reduce wear between joints.

Sedentary office workers: Long-term desk work leads to stiff shoulders, necks, and lumbar spine, and poor blood circulation. Eggshell membrane extract can resist inflammation, enhance the lubrication between joints, and relieve stiff lumbar spine.

YTBIO: Professional Eggshell Membrane Extract Powder Manufacturer&Supplier

YTBIO has been committed to the production of natural organic food since its establishment in 2014.We focus on providing customers with high-quality eggshell membrane extract powder. Whether you are a raw material purchaser, brand manufacturer or channel partner, please feel free to inquire. We will provide you with professional services.