Genipin Powder

Genipin Powder: What is it?

Genipin powder is an iridoid compound extracted from the fruit of the natural plant Gardenia jasminoides. It is the core functional component of genipin after enzymatic hydrolysis. Its molecular structure (C₁₁H₁₄O₅) endows it with multiple biological activities and unique application value: Genipin not only has clear effects such as promoting nerve regeneration, improving insulin secretion, and anti-inflammatory and liver-protective properties, but also, due to its excellent biocompatibility, it is widely used as a natural cross-linking agent in tissue engineering; the "gardenia blue" pigment produced by its reaction with amino acids has been approved as a safe colorant for use in food and cosmetics. This dual advantage of both biological activity and functional properties makes genipin an important natural raw material in many fields such as medicine, biomaterials, and the food industry.

YTBIO: Providing High-Quality Genipin Powder and Services

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com

Genipin Powder: Efficacy and Mechanism of Action

1.Neuroprotective and Repairing Effects

Genipin powder promotes neuronal axon regeneration and improves nerve conduction function, exhibiting a clear repair effect on peripheral nerve damage and central nervous system degenerative diseases. By regulating the expression of neurotrophic factors, it offers therapeutic potential for neurological diseases such as Alzheimer's disease.

2.Metabolic Regulation

In terms of glucose metabolism, genipin effectively promotes insulin secretion and improves insulin sensitivity by regulating UCP2 protein and calcium signaling pathways. It also slows the progression of diabetic nephropathy and protects kidney function from damage caused by a high-glucose environment.

3.Anti-inflammatory and Organ Protection

Genipin significantly reduces systemic inflammatory responses by inhibiting inflammatory pathways such as NF-κB. In terms of liver protection, it effectively alleviates chemically induced liver damage by enhancing bilirubin metabolism and inducing protective autophagy.

4.Bioactive Properties

It possesses broad-spectrum antibacterial, anti-allergic, and antioxidant properties, effectively scavenging free radicals and inhibiting the release of inflammatory mediators, demonstrating application value in the prevention and treatment of respiratory and skin diseases.

Genipin Powder: Application Areas

Biomaterials

As a high-performance natural biocrosslinking agent, genipin powder is widely used in tissue engineering and regenerative medicine. It can be used to prepare tissue engineering scaffolds such as artificial bones and blood vessels, as well as to develop biomaterials such as drug delivery systems and medical adhesives. Its excellent biocompatibility provides a safety guarantee for clinical applications.

Food Industry

In the food industry, genipin reacts with amino acids to produce gardenia blue, a safe, natural blue pigment widely used in the coloring of beverages, candies, and other foods. It can also improve food texture through cross-linking and is used in processing steps such as oil encapsulation to enhance product stability.

Cosmetics Industry

Due to its antioxidant properties, genipin has become an important ingredient in anti-aging skincare products, effectively delaying skin aging and improving skin tone, playing a vital role in various skincare and makeup products.

Biotechnology

In biotechnology, genipin, as a highly efficient enzyme immobilization crosslinking agent, significantly improves enzyme stability and utilization efficiency, and has important application value in biocatalysis and industrial production processes.

Pharmaceuticals

Genipin demonstrates multiple application values ​​in the pharmaceutical field. Its outstanding neuroprotective and repair capabilities make it an important candidate ingredient for treating neurodegenerative diseases and peripheral nerve damage; it plays a positive role in liver protection by promoting bilirubin metabolism and reducing hepatocyte apoptosis; at the same time, with its anti-inflammatory and immunomodulatory properties, it provides new treatment ideas for the relief of chronic inflammatory diseases and allergy symptoms; in terms of metabolic regulation, it can also assist in blood glucose management by improving insulin resistance.

Genipin Powder, Extract from Gardenia: New Hope for Nerve Regeneration

Recent research from multiple research centers in the United States has discovered that genipin, a natural compound extracted from the traditional medicinal plant gardenia, shows significant potential in promoting nerve regeneration. This study, published in *Science Translational Medicine*, represents a breakthrough in the treatment of familial autonomic dysfunction, a rare genetic disease.

Familial autonomic dysfunction is a neurological disorder caused by mutations in the ELP1 gene, characterized by abnormal development and progressive degeneration of the peripheral nervous system. Patients often experience severe symptoms such as respiratory regulation disorders, abnormal body temperature, and arrhythmias, and currently there is no effective treatment.

While screening hundreds of compounds, the research team unexpectedly discovered that genipin can effectively protect sensory neurons from degeneration. In laboratory studies, this compound not only repaired the normal developmental trajectory of neurons in patients but also successfully halted the early degeneration process of nerve cells. Even more encouragingly, genipin can promote the regeneration of damaged axons and has also shown an effect of improving peripheral neurogenesis in animal models.

Genipin rescues sensory neuron degeneration in FD cell model

Scientists speculate that the therapeutic effect of genipin may be related to its ability to enhance extracellular matrix cross-linking. This discovery opens new avenues for the treatment of peripheral nerve injuries and degenerative diseases.

It is worth noting that the medicinal value of genipin powder has a long history. In traditional Chinese medicine, gardenia flowers have long been used to treat symptoms such as inflammation and depression. Modern research has also found that natural pigments extracted from gardenia fruit can improve the texture of food, and its ability to induce programmed cell death makes it an important subject of research for anticancer drugs.

Although research on genipin is currently still in the laboratory stage, this discovery undoubtedly brings new hope for the treatment of nervous system diseases and provides strong evidence for the modern application of traditional medicinal plants.

Reference:

https://www.science.org/doi/10.1126/scitranslmed.adq2418

FAQ

Q: What are the specific details of YTBIO's genipin raw material?

A: We provide high-purity genipin raw material (CAS 6902-77-8), with a purity of 98%, derived from the natural plant Gardenia jasminoides Ellis. The product is a fine powder, manufactured in strict accordance with international quality standards.

Q: What are the main applications of genipin in the pharmaceutical field?

A: Based on the latest research, our genipin raw material has groundbreaking applications in the pharmaceutical field:

Neurological regeneration: Promotes the regeneration of peripheral nerve axons, providing therapeutic potential for neurodegenerative diseases.

Metabolic regulation: Improves insulin sensitivity through a unique mechanism.

Organ protection: Has a clear protective effect on the liver and kidneys.

Anti-inflammatory properties: Effectively inhibits inflammatory responses.

Q: How does YTBIO guarantee the quality of its genipin raw material?

A: We have established a comprehensive quality assurance system:

Our production facilities are certified by cGMP and ISO9001 quality management systems.

We hold ISO22000 and HACCP food safety management system certificates.

We have obtained EU&NOP organic certification, Kosher, BRC, Halal, and other specialized certifications.

We provide complete quality analysis certificates for each batch of products.

Q: Can you provide samples?

A: Of course. We are happy to provide you with free samples so you can evaluate the quality of our products. Samples are free, but you will be responsible for the shipping costs.

Q: What is the delivery time? How is logistics handled?

A: After receiving payment, we typically prepare and ship your product within 3-5 business days. We can arrange ocean freight, air freight, or international express delivery based on your needs. We work with trusted logistics partners to ensure safe and timely delivery of your goods to your designated port or address.

Q: How do I get started with YTBIO?

A: We are eager to collaborate with major global brands and partners. Please visit the YTBIO official website and submit your specific requirements through the "Contact Us" page. Our professional team will promptly provide you with detailed product technical documents (TDS), certifications (COA), and competitive solutions.​​​​​​​