Indole-3-Carbinol Powder

What Is Indole-3-Carbinol?

Indole-3-Carbinol Powder (I3C), an organic compound derived from phytochemicals abundant in cruciferous vegetables such as broccoli, Brussels sprouts and kale, has a variety of biological activities. It can be converted into 3,3'-diindolylmethane (Dim) in the body. Both compounds can change multiple signaling pathways and related molecules, controlling different cellular events such as oxidation, inflammation, proliferation, differentiation, apoptosis, angiogenesis and immunity, thus having the potential to prevent a variety of chronic diseases. As a powerful health product, it is receiving increasing attention. Known for its potential health benefits, including supporting hormone balance and enhancing the detoxification process, I3C is an ideal additive for food and beverage manufacturers aiming to meet consumers' growing demand for nutritional products.

Product Specifications

Features

• It has high bioavailability and can be effectively absorbed and utilized by the human body.
• It has a conjugated system, which makes it have strong biological activity.
• It is soluble in organic solvents such as alcohol, ether, and chloroform, but insoluble in water.
• It can be prepared by chemical synthesis and plant extraction. The chemical synthesis method has the advantages of high finished product yield, good quality, and green environmental protection.

Physiological Functions

Improve immunity

I3C can enhance the body's immune function and improve the body's ability to resist disease.

Anti-inflammatory

It can inhibit inflammatory responses and reduce the release of inflammatory mediators, such as VEGF, NO, IL-6 and matrix metalloproteinases (MMPs).

Anti-estrogen

I3C can change the metabolism of estrogen, increase the production of 2-hydroxyestrogens that have therapeutic effects on breast cancer, and reduce estrogen metabolites that have negative effects.

Liver protection

It can promote the activity of liver enzymes, especially the cytochrome P450 enzyme system related to detoxification, helping the body to metabolize and eliminate toxins and carcinogens more effectively.

Endocrine balance

It has anti-estrogen effects and can increase the excretion of estrogen in urine to balance the hormone levels in the body.

Improve blood lipids

It helps to increase high-density lipoprotein (HDL) cholesterol levels and reduce low-density lipoprotein (LDL) cholesterol levels, thereby reducing the risk of cardiovascular disease.

Neuroprotection

I3C may inhibit excessive microglial activation by reducing inflammation and has potential protective effects against neurodegenerative diseases.

Literature Sharing: Indole-3-Carbinol Powder May Delay Ovarian Aging

​​​​​​​A study provides new scientific evidence for the potential applications of indole-3-carbinol powder (I3C) in women's health. Published in *Biochemical Pharmacology*, the study found that I3C exhibited ovarian protective effects in an aged mouse model, mitigating ovarian aging-related oxidative stress, apoptosis, and fibrosis, while improving ovarian tissue condition and protecting follicular reserve.

The study suggests that this effect of I3C may be related to its regulation of the Nrf2/HO-1 antioxidant signaling pathway. I3C can promote the translocation of Nrf2 to the nucleus and enhance the expression of antioxidant-related proteins such as HO-1, thereby helping to reduce the accumulation of reactive oxygen species (ROS) and lipid peroxidation products, and alleviating cell damage caused by oxidative stress. In in vitro granulosa cell experiments, I3C also alleviated H₂O₂ and D-galactose-induced oxidative damage, mitochondrial dysfunction, and apoptosis. However, the protective effect of I3C was significantly weakened when Nrf2 was inhibited, further supporting the possibility that Nrf2/HO-1 may be an important molecular mechanism of action.

Animal experiments showed that I3C treatment increased the number of primordial follicles and total follicles in aged mice, accompanied by a decrease in ovarian fibrosis-related indicators. This suggests that I3C may protect ovarian function and follicular reserve by mitigating oxidative stress and tissue fibrosis, and reducing excessive follicle activation. The study also showed that under the tested conditions, I3C did not have a significant adverse effect on ovarian morphology, follicle number, or fibrosis indicators in young mice.

This study further expands the research value of I3C: in addition to its status as a natural indole compound in cruciferous plants, the effects of I3C on oxidative stress, apoptosis, and the Nrf2/HO-1 signaling pathway also provide new directions for its development in products related to women's health, anti-oxidation, and healthy aging.

Main Applications

Health Products

As a safe and effective ingredient, I3C is used in nutritional supplements and health food additives.

Medicine

In the pharmaceutical industry, it has a variety of effects, including antioxidant, anti-inflammatory, improving immunity and promoting liver detoxification. In addition, it also has the effects of interfering with nucleic acid biosynthesis, directly affecting DNA structure and function, interfering with transcription process and preventing RNA synthesis, interfering with protein synthesis and function.

Contact Us

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Indole-3-Carbinol Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

​Tel:86-029-86478251 / 86-029-86119593

Whatsapp:8617782577059

Email:sales@sxytorganic.com