L-5-Methyltetrahydrofolate Calcium

What is L-5-Methyltetrahydrofolate Calcium?

L-5-Methyltetrahydrofolate Calcium, referred to as L-5-MTHF, is a coenzyme form of folic acid and the most biologically active and functional form of folic acid. Ordinary folic acid can only participate in the methylation process and DNA synthesis after conversion to it, and is easier to absorb than ordinary folic acid. It is widely used as a derivative of tetrahydrofolate.

It is an important nutritional supplement and is widely used in the food, health care and pharmaceutical industries. As a manufacturer, it is crucial for YTBIO to provide high-quality L-5-MTHFCa ingredients. As a reliable manufacturer, we have advanced production facilities, strict quality control measures and a good industry reputation.

Features

Stability: This form is very stable, can exist naturally in plasma, and can be directly used by cells without masking VB12 deficiency.

Absorption and bioavailability: The bioavailability is about two to three times that of ordinary folic acid, which means it is more easily absorbed and used by the body.

High biological activity: 5-MTHF is more easily absorbed and used by the body than ordinary folic acid, so when supplementing folic acid, using the 5-MTHF form can more effectively increase the level of folic acid in the body.

Biochemical mechanism: 5-MTHF plays a central role in biochemical processes and participates in the operation of multiple enzymatic reactions and cofactors. It can be converted into S-adenosylmethionine (SAMe) in the body, which participates in multiple biochemical processes as a methyl donor.

Function

Promote DNA synthesis and cell growth

It is the active form of folic acid, involved in DNA synthesis and cell growth, and is essential for maintaining cell health.

Support cardiovascular health

Helps to reduce homocysteine ​​levels, thereby supporting cardiovascular health.

Support nervous system function

L-5-Methyltetrahydrofolate Calcium helps maintain the health of the nervous system, it can help support nervous system development.

Promote energy production and hormone metabolism

Participates in energy production and hormone metabolism, which is very important for maintaining overall health.

Ability to cross the blood-brain barrier

Ability to directly cross the blood-brain barrier, which is essential for brain health and function.

Prevent Alzheimer's disease

May help reduce the accumulation of beta-amyloid in the brain, thereby preventing Alzheimer's disease.

Application

Food additives

L-5-Methyltetrahydrofolate Calcium is widely used in the field of food additives, mainly in fortified foods to meet the nutritional needs of specific groups of people for folic acid.

Health products

In the field of health products, it is widely used to produce various health products, especially health products for specific groups such as pregnant women and the elderly.

Medicine

In the field of pharmaceuticals, it is mainly used to treat diseases related to folic acid deficiency and as an intermediate in drug synthesis.

Preparation Method

1. Mix folic acid, a first reducing agent, a first catalyst and a first alkaline solvent, perform a reduction reaction and prepare (R, S)-6-tetrahydrofolate.

2. Mix the (R, S)-6-tetrahydrofolate, p-toluenesulfonic acid and a first antioxidant, perform chiral separation and prepare 6(S)-tetrahydrofolate p-toluenesulfonate.

3. Mix the 6(S)-tetrahydrofolate p-toluenesulfonate, a methylating agent and a second alkaline solvent, perform a methylation reaction, mix the product of the methylation reaction, a second reducing agent and a second catalyst, perform a ring-opening reaction and prepare L-5-methyltetrahydrofolate.

4. Mix the L-5-methyltetrahydrofolate, a second antioxidant and a third alkaline solvent, decolorize, filter, and take the filtrate to react with a calcium salt to form a salt and prepare L-5-MTHFCa.

Formulation Of L-5-Methyltetrahydrofolate Calcium

Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality L-5-Methyltetrahydrofolate Calcium and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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