Leech Extract

Are You Familiar With Leech Extract?

Leech extract is a bioactive substance obtained from the salivary glands of leeches. Its core value lies in its unique multi-component synergistic mechanism. The extract's main functional component is hirudin, a natural thrombin inhibitor that forms a stable complex with thrombin, effectively blocking the conversion of fibrinogen to fibrin. Simultaneously, its histamine-like substances improve microcirculation by dilating blood vessels, and, combined with the inhibitory effect of antithrombin on platelet aggregation, form a triple antithrombotic pathway. These properties give it outstanding value in the prevention and treatment of cardiovascular and cerebrovascular thrombotic diseases, particularly demonstrating significant clinical application potential in reducing postoperative thrombosis risk and improving diabetic microvascular complications, making it an important bioactive raw material bridging traditional medical wisdom and modern treatment technologies.

YTBIO: Providing High-Quality leech extract and Services

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at

sales@sxytorganic.com 

Core Efficacy and Mechanism of Action of Leech Extract

1. Excellent Anticoagulant Effect​​​​​​​

Hirudin in leech extract can directly bind to thrombin to form a stable complex, effectively blocking the conversion of fibrinogen to fibrin. This specific inhibitory effect makes it a leader among natural anticoagulants, possessing irreplaceable value in the prevention and treatment of thrombotic diseases.

2. Improved Microcirculation

Through its histamine-like substances and vasoactive components, leech extract effectively dilates capillaries, reduces blood viscosity, and significantly improves tissue blood perfusion. This property makes it play a key role in the treatment of microcirculatory disorders such as diabetic microvascular complications and peripheral nerve dysfunction.

3. Anti-inflammatory and Analgesic Properties

The active ingredients in this extract can regulate the release of inflammatory mediators and inhibit the excessive activation of inflammatory cells, thereby reducing tissue swelling and pain responses. Clinical studies have shown that it has a clear improving effect on inflammatory diseases such as rheumatoid arthritis and osteoarthritis.

4. Tissue Repair Promotion Capacity

Leech extract can stimulate the proliferation and differentiation of fibroblasts, accelerate collagen synthesis and deposition, and effectively promote the formation of granulation tissue at wound sites. This property makes it show significant application value in the healing of chronic ulcers and postoperative wound repair.

5. Potential for Multiple Adjunctive Therapies

In addition to its main efficacy, studies have also found that leech extract shows potential benefits in regulating lipid metabolism and improving kidney function, providing new research directions for expanding its clinical applications. These scientifically validated efficacies make leech extract an important natural pharmaceutical ingredient in the prevention and treatment of cardiovascular and cerebrovascular diseases and in tissue repair.

Applications of Leech Extract

The applications of leech extract are primarily concentrated in the medical and health fields, particularly showing significant effects in cardiovascular diseases, hematological diseases, gynecological diseases, and anti-inflammation.

**Cardiovascular and Cerebrovascular Fields:**

It plays a core role in the prevention and treatment of thrombotic diseases, suitable for the treatment and prevention of cerebral infarction, coronary heart disease, and other diseases, while also improving vascular complications caused by underlying diseases such as diabetes.

**Metabolic Diseases:**

It helps improve metabolic abnormalities such as hyperlipidemia and hyperuricemia by regulating blood status, providing comprehensive treatment options for patients with metabolic syndrome.

**Gynecological Diseases:**

It is used for common gynecological diseases such as menstrual disorders and chronic pelvic inflammatory disease, promoting the recovery of reproductive system function by improving local microcirculation.

**Musculoskeletal Diseases:**

It demonstrates value in the treatment of arthritis and the repair of sports injuries, effectively relieving pain and promoting tissue regeneration.

**Wound Repair:**

It significantly promotes the healing process of chronic wounds such as diabetic foot and pressure sores, improving the quality of wound repair.

**Sub-health Conditioning:**

It effectively improves sub-health conditions such as chronic fatigue and sleep disorders, enhancing quality of life.

Leech extract, with its unique pharmacological activity, has demonstrated significant therapeutic value in multiple medical fields, providing an important natural drug option for modern disease prevention and control systems.

Leech Extract: Does Hirudin Have Skin Care Benefits?

Ingredient Characteristics and Safety

Natural hirudin is a bioactive polypeptide extracted from the salivary glands of medicinal leeches. Its unique 65-66 amino acid sequence constitutes a small molecule single-chain structure, possessing excellent skin permeability. After systematic safety evaluation, this ingredient demonstrated good safety under topical conditions, with no skin irritation or sensitization, providing reliable assurance for cosmetic applications.

Antioxidant Activity Experimental Research:

·DPPH Free Radical Scavenging Experiment

Studies show that natural hirudin extract has a significant scavenging ability against DPPH free radicals, and the scavenging effect is positively correlated with concentration. With increasing extract concentration, its free radical scavenging rate continuously increases. This characteristic makes it a highly valuable active ingredient in anti-aging cosmetics, effectively delaying the skin aging process caused by oxidative stress.

·Hydroxy Free Radical Scavenging Experiment

In experiments targeting hydroxyl free radicals, natural hirudin exhibited a strong scavenging ability, and its effect also showed a concentration-dependent increase. Its mechanism of action lies in the fact that the active groups in its molecular structure can act as "hydrogen donors," effectively neutralizing highly destructive hydroxyl free radicals and blocking the chain reaction of damage initiated by free radicals. Given that hydroxyl free radicals are one of the main factors leading to oxidative aging of the skin, this discovery further solidifies the application of hirudin in anti-aging products.

·Superoxide Anion Scavenging Experiment

Experimental data show that natural hirudin achieves a 50% scavenging rate of superoxide anions at a concentration of 21.1 mg/mL. Although its scavenging efficiency is slightly weaker than that of vitamin C (which requires only 0.032 mg/mL to achieve the same effect), this result fully confirms its clear antioxidant activity. This property enables it to effectively neutralize free radicals in the environment and slow down oxidative damage to the skin, providing a solid scientific basis for the development of hirudin-based anti-aging cosmetics.

Schematic diagram of antioxidant activity experiment

Anti-aging Mechanism of Action

From the perspective of mechanism of action, natural hirudin exerts its anti-aging effects through multiple pathways: its ability to neutralize free radicals directly protects collagen from oxidative damage and maintains the normal structure of connective tissue; its unique molecular configuration contains multiple antioxidant amino acids, forming a synergistic antioxidant network; and its active sulfhydryl groups further enhance its ability to scavenge free radicals. These properties work together to address key aspects of skin aging, effectively improving problems such as decreased elasticity, wrinkle formation, and dull skin tone.

Application Value in Cosmetics

Based on its excellent antioxidant properties and reliable safety, natural hirudin has become an important active ingredient in anti-aging cosmetic formulations. This ingredient not only effectively combats skin damage caused by oxidative stress, but its small molecule characteristics also ensure the skin penetration efficiency of the active ingredients, providing a new solution for developing highly effective anti-aging products.

Reference: Xie Siyue, Guangdong University of Technology, Antioxidant Properties of Natural Hirudin and Its Application in Cosmetics, 2020, 6:1-15.

FAQ

Q: What are the core specifications of YTBIO hirudin raw materials?​​​​​​​

A: We provide high-quality hirudin raw materials with a bioactivity of 600-610 ATU/G. We also offer 150 ATU, 300 ATU/G, 500 ATU, and 800 ATU options.

Q: How does YTBIO guarantee the quality of its raw materials?

A: We have established a comprehensive quality assurance system:

Our production facilities strictly adhere to cGMP (Good Manufacturing Practice) and ISO9001 standards.

We hold ISO22000 and HACCP food safety management system certificates to ensure the purity of our raw materials.

We have obtained multiple international certifications, including EU&NOP organic, Kosher, BRC, and Halal, meeting global market access requirements.

Each batch of products undergoes rigorous bioactivity (ATU) testing and microbial control.

Q: Can you provide samples?

A: Of course. We are happy to provide you with free samples so you can evaluate the quality of our products. Samples are free, but you will be responsible for the shipping costs.

Q: What is the delivery time? How is logistics handled?

A: After receiving payment, we typically prepare and ship your product within 3-5 business days. We can arrange ocean freight, air freight, or international express delivery based on your needs. We work with trusted logistics partners to ensure safe and timely delivery of your goods to your designated port or address.

Q: How do I get started with YTBIO?

A: We are eager to collaborate with major global brands and partners. Please visit the YTBIO official website and submit your specific requirements through the "Contact Us" page. Our professional team will promptly provide you with detailed product technical documents (TDS), certifications (COA), and competitive solutions.