Lumbrokinase Powder

What is lumbrokinase?

Lumbrokinase powder is an enzyme complex extracted and separated from artificially cultivated earthworms. It is a slightly yellow powder. It contains plasmin and plasminogen activator, and also contains ingredients similar to tissue plasminogen activator (t-PA). It has been proven to have good clinical application value. It is a multi-molecule recombinant oral preparation with special affinity to thrombus (fibrin). It can track thrombolysis, effectively dissolve microthrombi, improve microcirculation, strengthen collateral circulation of heart and brain vessels, openly repair damaged endothelial cells, increase vascular elasticity, improve vascular oxygen supply function, reduce blood viscosity, reduce platelet aggregation rate, and inhibit the re-formation of thrombus.

COA ON Lumbrokinase Powder

Main Functions

1. Thrombolysis
As a biological gene active enzyme product, the most representative effect is that it has a strong thrombus dissolving effect. Its mechanism of action is: when it enters the body, it quickly combines with fibrin, the main component of thrombus embolus, and hydrolyzes it to achieve the purpose of dissolving thrombus. It not only hydrolyzes fibrin rich in plasminogen, but also hydrolyzes fibrin particles without plasminogen. Therefore, it has a powerful effect of thrombolysis and blood circulation for new and old thrombi. It has a strong effect on patients with thrombosis at all stages and has a positive effect. Through the blood concentration measurement and blood tracking test of fibrinolytic ability, its thrombolytic ability is much higher than urokinase and streptokinase. Thus, it has changed the traditional unsafe and inconvenient intravenous administration method of thrombus conditioning.

2. Anticoagulation
Through blood tracking, it was found that it can adsorb coagulation factors and hydrolyze them, while inhibiting the further adhesion of platelets on its surface. Therefore, while conditioning the existing thrombus, it can also prevent the occurrence of new thrombus, solving the medical problem of the detachment of wall thrombus and the formation of other tissue embolism during thrombus conditioning, which often occurs in clinical medicine, and enhances the safety of thrombolysis. At the same time, it has strong targeting in the process of thrombolysis and anticoagulation, and only adsorbs and hydrolyzes coagulation factors and platelets with a tendency to coagulate, without destroying the coagulation mechanism of blood, so there will be no thrombolytic bleeding.

3. Activating enzyme
Clinical observations have found that it activates the fibrinolytic system in vivo. It forms a long-term stable internal environment in the human body to prevent thrombosis, and has a long-term anti-thrombotic effect. In addition, it can significantly prolong the occlusion time of blood vessels, so that blood vessels do not need external drugs, but improve blood flow through their own elastic regulation, complete tissue perfusion, and enhance tissue vitality.

4. Living cells
It is the most active proteolytic enzyme, which can activate various cells in the human body, especially cells in shock and semi-shock states in insufficient blood supply tissues, which can quickly restore normal physiological functions and biological activities. Therefore, it has an excellent promoting effect on the recovery of cerebral thrombosis, sequelae of cerebral infarction and myocardial infarction.

Application In Medicine

1. Anti-inflammatory effect: It can stimulate the anti-inflammatory response in the body, promote the degradation of fibrin in the inflammatory site, and relieve inflammatory symptoms.
2. Promote wound healing: It has the effect of stimulating the proliferation of wound epithelial cells, accelerating the formation of new blood vessels and collagen fibers, and helps wound healing.
3. Dissolve blood clots: It can directly dissolve blood clots, improve blood circulation, and prevent cardiovascular diseases such as myocardial infarction and stroke.

Application In The Food Industry

1. Bread making: It can increase the softness and improve the texture of food in the dough, making the bread softer and more delicious.
2. Dairy processing: It has the function of coagulating protein in dairy processing and is used in the processing of cheese, yogurt, etc.
3. Meat processing: It can change the fiber structure of meat, making it more tender and smooth, and improving the taste.

Application In Environmental Protection

1. Sewage treatment: It can effectively degrade toxic substances in organic waste and sewage, help purify water bodies, and protect the environment.
2. Garbage disposal: It can promote the decomposition and decay process of organic waste, accelerate the degradation of garbage and reduce pollution to the environment.

Benefits To Human Health

1. Anti-aging: It has antioxidant effects, can neutralize free radicals, slow down the aging of cells and delay the aging process.
2. Immunity enhancement: It can improve the function of the immune system, enhance human resistance, and prevent the occurrence of diseases.
3. Improve cardiovascular health: It can promote blood circulation, reduce blood viscosity, prevent thrombosis, and maintain cardiovascular health.

Conclusion

​​​​​​​As a natural enzyme, it has a wide range of applications in medicine, food industry, and environmental protection. Its anti-inflammatory, healing, and thrombolytic effects are of great significance in the medical field. In the food industry, it can improve food texture, taste and product competitiveness. It can also be used in sewage treatment and garbage disposal, which helps protect the environment. It also has a positive impact on human health, including anti-aging, immune enhancement and cardiovascular health.

Case Studies Related to Lumbrokinase

I. Thrombolytic Therapy for Patients with Coronary Artery Disease

The human body possesses a sophisticated thrombolytic system within its blood vessels. Vascular endothelial cells secrete two key substances: t-PA (responsible for dissolving thrombi) and PAI (inhibiting t-PA activity). Patients with coronary artery disease have elevated PAI activity, leading to t-PA inhibition, decreased thrombolytic capacity, and a greater susceptibility to thrombus formation.

A study on patients with acute myocardial infarction showed that 12 hours after conventional treatment, plasma t-PA activity significantly increased. This improvement lasted for 3 days, gradually returning to pre-treatment levels by the 7th day. After 5 days of lumbrokinase treatment, the fibrinolytic system function of patients was significantly improved.

II. Rehabilitation Observation of Patients with Cerebral Infarction

Cerebral infarction accounts for 50%-60% of all cerebrovascular diseases and is one of the leading causes of disability in middle-aged and elderly people. In the acute phase, controlling cerebral edema and increasing cerebral blood flow are crucial for treatment.

A study involving 665 patients with cerebral infarction showed that after 15-28 days of continuous oral administration of lumbrokinase:

Effective efficacy: 60.94% - 73.66%

Overall effective rate: 88.0% - 98.88%

Thrombus volume reduction: 98.6% of patients experienced significant reduction in thrombus volume, with an average reduction rate of 74.1%

After 3-5 days of medication:

Improvement rate of facial paralysis and limb numbness: 79.85%

Improvement rate of dizziness and headache: 95.95%

Improvement rate of tongue stiffness and aphasia: 94.7%

Improvement rate of facial paralysis: 91.3%

Improvement rate of hemiplegia: 92.3%

Improvement rate of limb numbness: 92.9%

Improvement rate of hand and foot stiffness: 85.7%

III: Platelet activation inhibition in diabetic patients

High platelet activation is a common problem in diabetic patients. Plasma GMP140 and TXB2 are two important indicators reflecting platelet activation. Elevated levels of these indicators suggest that platelets are more prone to aggregation and blood vessels are more likely to constrict, which is one reason why diabetic patients experience earlier onset of arteriosclerosis and a higher incidence of microvascular complications.

After 2 weeks of oral administration of lumbrokinase to diabetic patients:

· Plasma TXB2 levels decreased significantly, reaching levels not significantly different from the healthy control group.

· Plasma GMP140 levels also decreased significantly.

→ Conclusion

Lumbrokinase can effectively inhibit platelet activation and aggregation in diabetic patients, and has positive significance in delaying or preventing diabetes-related vascular complications.

Formulation Support

Capusle Formulation

Tablet Formulation

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