Phenylethyl Resorcinol

What is Phenylethyl Resorcinol?

Phenylethyl Resorcinol is also known as SymWhite377, or 377 for short. It is a white to beige powder that is slightly soluble in water but easily soluble in propylene glycol and polar oils. Its structure is similar to tyrosine, and it also has a bisphenol structure similar to hydroquinone. This compound was originally obtained from silver pines by chemical modification and has high whitening activity. It is a cosmetic raw material with melanin inhibition and whitening effects. It can effectively reduce the production of melanin in the skin by inhibiting the synthesis of tyrosinase, and has whitening, freckle removal and anti-aging effects. As an effective whitening and antioxidant ingredient, it is suitable for a variety of cosmetics and skin care products, but it is necessary to pay attention to its specific storage and use conditions when using it.

Product Details Table

Characteristics

Inhibits tyrosinase activity

It can significantly inhibit the activity of tyrosinase, thereby reducing the production of melanin. This inhibitory effect is 210 times that of kojic acid, showing its powerful whitening effect.

Stability and safety

It has poor light and heat stability, is easily oxidized and discolored, and is easily chelated with metal ions. Despite this, its use in cosmetics is considered safe and has no potential for irritation and sensitivity.

Solubility

Phenylethyl Resorcinol is slightly soluble in water, easily soluble in propylene glycol and polar oils, and is easy to use in cosmetic formulations.

Function

Whitening and spot-lightening

By inhibiting the activity of tyrosinase and reducing the synthesis of melanin, it can lighten pigmentation such as spots and freckles and improve uneven skin tone.

Antioxidant

As an antioxidant, it can neutralize free radicals in the skin, reduce the damage of oxidative stress to the skin, and delay the aging process of the skin.

Anti-inflammatory repair

It has a certain anti-inflammatory effect, can reduce skin inflammation, promote the repair of damaged skin, and improve skin sensitivity and redness.

Moisturizing and nourishing

It helps to improve the skin's moisturizing ability, improve dryness and roughness, and make the skin softer and smoother.

Regulate skin oil

It can regulate sebum secretion, improve oily skin, and reduce the formation of acne and blackheads.

Whitening Mechanism

Competitive inhibition

Its molecular structure is similar to tyrosine, and it can competitively bind to the active site of tyrosinase, blocking the initial step of tyrosine conversion to DOPA.

Non-competitive inhibition

It exhibits non-competitive inhibition on the diphenolase activity of tyrosinase, reducing melanin production by interfering with the catalytic process of the enzyme.

Molecular docking effect

Experiments show that it forms a hydrogen bond with the MET A:280 residue in the active center of tyrosinase, and stably binds through hydrophobic interaction, further inhibiting enzyme activity.

Inhibition of DOPA oxidation

Phenylethyl Resorcinol prevents the conversion of DOPA to DOPAquinone through the bisphenol hydroxyl structure, thereby interrupting the melanin synthesis chain reaction.

Regulating the MITF signaling pathway

Downregulates the expression of microphthalmia-related transcription factor (MITF) and its downstream proteins TRP1 and TRP2, reducing the formation of melanosomes in melanocytes.

Inhibition of oxidative reactions

Reduces oxidative stress by neutralizing reactive oxygen species (ROS), and indirectly reduces pigment deposition caused by oxidative damage during melanin synthesis.

Stabilizes formula activity

Its antioxidant properties help delay the degradation of itself and other ingredients, and improve the stability of whitening products.

Promotes melanin metabolism

It can accelerate the metabolism of the stratum corneum, help the melanin that has been formed to be discharged with the renewal of the epidermis, and improve uneven skin tone.

Structural Properties

Phenylethyl resorcinol (377) is a derivative of m-dihydroxybenzene, also known as resorcinol. Resorcinol is a phenolic compound naturally obtained from argan oil. Resorcinol has antibacterial and anti-pigmentation properties. Among various resorcinol derivatives, 377 exhibits stronger anti-pigmentation activity than resorcinol due to its different mechanism of action. In addition, topical application of 377 shows no cytotoxic effects and also exhibits its antioxidant benefits. Therefore, 377 is often used as a new whitening ingredient in facial care products.

Specific Application Scenarios

Whitening products

Adding it to cream or lotion can effectively inhibit the activity of tyrosinase, reduce the production of melanin, thereby fading spots and freckles and improving uneven skin tone.

Anti-aging products

Using its antioxidant properties, developing antioxidant creams can neutralize free radicals, reduce the damage of oxidative stress to the skin, and delay the skin aging process.

Sunscreen products

Adding Phenylethyl Resorcinol to sunscreen can enhance the sunscreen effect of the product and reduce skin pigmentation caused by ultraviolet rays.

Facial mask

adding it to the facial mask can be quickly absorbed by the skin, and play a variety of effects such as whitening, moisturizing, and repairing.

Toner/make-up water

adding it to toner or make-up water in an appropriate amount can adjust the water and oil balance of the skin, and at the same time play a whitening and anti-oxidation role.

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Phenylethyl Resorcinol and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

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