Pure Sericin

Do You Know Sericin?

Pure sericin is a natural water-soluble globulin extracted from silkworm cocoons, accounting for approximately 20%–30% of the total weight of silk. Secreted by the silkworm's silk glands, it surrounds fibroin, binding fibers, forming the cocoon shell, and protecting the internal structure. This protein is mainly composed of 18 amino acids, including the eight essential amino acids required by the human body, with high levels of serine, glycine, tyrosine, and alanine. Its molecular structure is predominantly random coiled, containing a β-sheet conformation but lacking an α-helix structure. Rich in polar amino acids such as arginine and lysine, pure sericin exhibits excellent water solubility, dissolving in hot water and acidic/alkaline solutions. Sericin demonstrates superior biocompatibility, biodegradability, and antioxidant activity. With continuous improvements in extraction technology, sericin is now being produced and applied on a large scale in the food, pharmaceutical, and cosmetic industries.

YTBIO: Providing High-Quality Pure Sericin and Services

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com

What Are The Functions Of Sericin?

1. Skin Moisturizing and Repair

Pure sericin is rich in hydrophilic amino acids such as serine and aspartic acid. Its composition is highly similar to the body's natural moisturizing factors, giving it excellent moisture absorption and retention capabilities. It can increase skin hydration and enhance elasticity, thus being widely used as a moisturizing ingredient and skin barrier repair agent in cosmetics.

2. Antioxidant and Anti-aging

This protein has a significant free radical scavenging ability, inhibiting lipid peroxidation and slowing down skin aging caused by oxidative stress. Simultaneously, sericin can inhibit tyrosinase activity, helping to reduce melanin production and providing a comprehensive skincare effect of brightening skin tone and delaying aging.

3. Wound Healing and Tissue Regeneration

In medical applications, sericin can promote fibroblast proliferation and collagen synthesis, accelerating wound closure and epithelial regeneration, making it particularly suitable for repairing infected wounds. Its good biocompatibility helps reduce inflammation and supports cell adhesion and tissue reconstruction, therefore it is used in functional wound dressings.

4. Antibacterial and Anti-inflammatory Properties

Studies show that sericin possesses broad-spectrum antibacterial and anti-inflammatory capabilities, reducing the risk of wound infection and alleviating inflammatory responses, providing auxiliary protection for skin care and medical repair.

5. Biomaterials and Drug Delivery

Due to its excellent biocompatibility and biodegradability, pure sericin is often used as a tissue engineering scaffold material, supporting the directed differentiation of stem cells and the regeneration of various tissues such as bone and cartilage. Furthermore, through modification or encapsulation, sericin can also serve as a drug carrier, achieving targeted delivery and controlled release, thus enhancing the therapeutic effect.

Sericin: Multidimensional Applications

As a rich and high-performance natural biopolymer, Pure sericin's applications have expanded from traditional textiles to cutting-edge fields such as modern beauty, medicine, food, and new materials.

Functional Foods and Nutritional Supplements

Natural Antioxidant: Effectively inhibits the oxidative rancidity of oils and the activity of polyphenol oxidase, extending the shelf life of fat-containing foods (especially dairy products and edible oils), providing a safe and natural preservative solution.

Nutritional Enhancer: Rich in various amino acids, it has been found to promote the absorption of trace elements such as zinc, iron, and calcium, possessing the potential to be developed into nutritional supplements or functional health foods.

Texture Modifier: Can act as a natural emulsifier and stabilizer, improving the taste and physical stability of beverages, dairy products, and other foods.

Cosmetics and Personal Care

Highly Effective Moisturizing and Anti-aging: Its amino acid composition is highly similar to the body's natural moisturizing factor, exhibiting excellent hygroscopicity and forming a moisturizing film on the skin surface for long-lasting hydration. Simultaneously, its powerful antioxidant capacity effectively scavenge free radicals, delaying photoaging of the skin.

Skin Whitening and Texture Improvement: By inhibiting tyrosinase activity, pure sericin reduces melanin production at its source, achieving a brighter complexion and fading dark spots. It also promotes collagen synthesis, enhances skin elasticity, and reduces wrinkles.

Hair Repair: Forming a protective film on the hair surface, it significantly enhances hair shine, elasticity, and tensile strength, repairing damage caused by sun exposure or chemical treatments.

Biomedicine

Wound Repair and Tissue Engineering: It can be formulated into hydrogels, dressings, or scaffolds, significantly accelerating skin wound healing, promoting the regeneration of hair follicles, blood vessels, and other appendages, and effectively inhibiting inflammation and reducing scarring. In bone tissue engineering, it can guide hydroxyapatite deposition, promote osteogenic differentiation, and repair bone defects; in the field of nerve repair, sericin-based conduits can provide support for Schwann cells and guide peripheral nerve regeneration.

Intelligent Drug Delivery Systems: As a carrier, sericin can load small molecule drugs, nucleic acids (such as siRNA), or functional proteins through physical encapsulation or chemical bonding, achieving targeted drug delivery and controlled release, thereby improving efficacy and reducing side effects. Textiles and Advanced Materials

It offers new green options for materials science:

Functional textile finishing: By fixing sericin onto synthetic fabrics through finishing processes, textiles with multiple functions such as long-lasting moisturizing, antibacterial, and UV protection can be developed, effectively improving the wearing comfort of synthetic fabrics.

Flexible electronics and energy storage devices: Utilizing its film-forming properties and biocompatibility, sericin is used to develop emerging devices such as wearable electronic devices, implantable biosensors, and supercapacitors, demonstrating its potential in the field of green electronics.

Other fields

Green and environmentally friendly materials: Utilizing its fully biodegradable properties, sericin is used to develop eco-friendly disposable tableware, packaging materials, and agricultural films to reduce "white pollution."

3D bioprinting: As a basic component of bio-inks, pure sericin is used to accurately construct complex artificial tissue and organ models, supporting regenerative medicine and drug screening.

Environmental remediation: Its excellent adsorption properties make it promising for wastewater treatment, especially for the adsorption of heavy metal ions.

Sericin: A Revolutionary Skincare Ingredient

Sericin, a water-soluble natural protein, exhibits remarkable application value in the skincare field due to its unique amino acid composition and molecular structure. Its molecular conformation is predominantly random coiled, with peptide chains rich in long side-chain amino acids such as arginine, lysine, and glutamic acid, as well as numerous hydrophilic groups (such as –OH, –COOH, and –NH₂), collectively endowing sericin with excellent moisturizing and hygroscopic properties.

Sericin Composition and Skin Affinity

Pure sericin contains more than ten amino acids, including several essential amino acids, accounting for over 16.5% of the total. Its amino acid composition is highly similar to the natural moisturizing factors of human skin. Unlike silk fibroin, which is poorly soluble in water, sericin possesses excellent water solubility and skin permeability, allowing it to be directly applied to cosmetics without strong chemical treatment, effectively avoiding nutrient loss and structural damage. Its components, such as serine, aspartic acid, and glutamic acid, can be absorbed through the interepidermal spaces and glands, providing nutrition to the skin, enhancing cell vitality, and promoting metabolism. Long-term use can improve skin elasticity and overall skin texture.

The Moisturizing and Hygroscopic Mechanism of Sericin

If the moisture content of the stratum corneum is below 10%, it will cause dryness and roughness. The amino acid composition of sericin is highly consistent with natural moisturizing factors. The polar groups in its molecules can bind and lock in moisture, transferring it to the stratum corneum, thereby maintaining the skin's hydration. Experiments show that only 3% sericin solution can achieve the hygroscopic effect of 60% glycerin solution, proving that it can still exert excellent moisturizing effects at very low addition levels, making it a highly effective and safe moisturizing ingredient.

The Influence of Molecular Weight Differences on Skin and Hair Care Functions

The functional effects of sericin are closely related to its molecular weight:

Low molecular weight sericin: Small molecule sericin in the range of 5000–7000 Da is more easily penetrated by the stratum corneum and absorbed by the skin. It is suitable for skin care products and can improve fine lines and enhance skin radiance.

Medium molecular weight sericin: Sericin in the range of 12,000–17,000 Da is suitable for hair care products. It can adsorb onto the hair surface and form a protective film, enhancing hair elasticity and strength. Experiments show that hair treated with 1% sericin exhibits an elasticity increase of over 58% and effectively resists cuticle damage caused by perming agents, repairing hair structure.

Scanning electron micrographs of untreated hair (Ⅰ), hair treated with perming agent (Ⅱ), and hair first coated with sericin, dried, and then treated with perming agent (Ⅲ).

Whitening Efficacy and Tyrosinase Inhibition Mechanism

The whitening ability of sericin protein stems from its inhibition of tyrosinase activity. Studies have shown that adding 1% sericin can reduce enzyme activity by over 50%, with an inhibition rate of 52.39% on melanin production. The mechanism lies in the fact that hydroxy amino acids such as serine and threonine, as well as trace elements (such as copper and iron) in sericin, can complex with tyrosinase, interfering with its catalytic action, thereby reducing melanin synthesis and maintaining fair skin.

Conclusion

Pure sericin, as a water-soluble, highly affinity natural protein raw material, possesses an ideal amino acid composition and molecular flexibility, enabling it to play multiple roles in skincare and haircare products:

Providing nutrition and enhancing skin metabolism and elasticity;

Highly moisturizing, maintaining ideal skin hydration;

Precisely tailored to skincare or haircare applications based on molecular weight differences;

Inhibiting melanin production for natural whitening;

Repairing damaged hair and forming a protective film.

Therefore, sericin is not only an ideal substitute for natural moisturizing factors but also an important functional ingredient for developing highly effective and safe cosmetics, possessing broad development prospects and application potential.

Reference original link:

10.4028hm.scientific.net/AMR.796.416​​​​​​​

Certificates：

Complete compliance documentation can be provided according to market demand.

Shipping & Payment：

Multiple international logistics options and support for various payment methods.

Exhibitions：

Leveraging our own factory and professional R&D team, we not only provide a stable supply of Bulk organic kale powder raw materials, but also assist clients in formula optimization and product customization. Our factory strictly adheres to international quality management and food safety systems, and has obtained multiple authoritative certifications including cGMP, ISO22000, ISO9001, BRC, Kosher, and Halal, fully meeting the compliance and access requirements of the global market.

Whether you are developing new products or seeking a long-term, stable raw material partner, please feel free to contact us for samples, technical support, and customized solutions.

Tel:86-029-86478251 / 86-029-86119593
Whatsapp:8617782577059
Email:sales@sxytorganic.com​​​​​​​