Sodium Hyaluronate Powder Bulk

What is sodium hyaluronate?

Sodium hyaluronate is the sodium salt form of hyaluronic acid. It is a polymer linear mucopolysaccharide composed of N-acetylglucosamine and D-glucuronic acid disaccharide units repeatedly linked together. It is widely present in connective tissue in animals and humans. in the extracellular matrix of tissues.

Its highly stretched and irregularly coiled configuration in aqueous solution occupies a large area, and the molecular chains are entangled with each other to form a continuous network structure, making sodium hyaluronate like a "molecular sponge" that can absorb and Holds thousands of times its own weight in water.

Sodium hyaluronate powder bulk is an acidic mucopolysaccharide macromolecule widely found in connective tissues of humans and animals. It has important functions in the body such as retaining water, regulating osmotic pressure, maintaining tissue morphology, as well as lubrication, diffusion barrier and stress buffering. Starting from the age of 25, hyaluronic acid in the human body will gradually lose. At the age of 30, only 65% of young skin is left, and at 50, only 25% of young skin is left. Hyaluronic acid is lost with age. Over time, , the skin will gradually lose elasticity and luster, and aging, wrinkles and sagging will also occur.

Sodium hyaluronate Powder is now widely used in many fields such as medicine, beauty cosmetics, food and textiles. Studies have proven that sodium hyaluronate has functions such as moisturizing, lubricating, antioxidant, anti-apoptotic, anti-aging, promoting penetration, anti-inflammation, and barrier repair. When used in cosmetics, it can play a unique role in protecting the skin. , can keep the skin moist, smooth, delicate, tender and elastic, and has the functions of anti-wrinkle, anti-aging, beauty and health care and restoring the physiological functions of the skin.

Sodium hyaluronate has a very strong water absorption capacity, and the water it can adsorb is about 500-1000 times its own mass, so it is a recognized natural moisturizing factor.

Commonly used sodium hyaluronates include:

① Oligomeric sodium hyaluronate (molecular weight less than 10,000 Da);

②Small molecule sodium hyaluronate (molecular weight 10,000 Da-1 million Da);

③Medium molecule sodium hyaluronate (molecular weight 1 million Da-1.8 million Da);

④ Macromolecule sodium hyaluronate (molecular weight > 1.8 million Da);

The skin care function of sodium hyaluronate mainly depends on its molecular weight and dosage. Generally speaking, the greater the molecular weight of sodium hyaluronate, the greater the entanglement between molecules, forming a wider molecular network. The moisturizing and breathable film formed on the skin surface makes the skin moist and shiny, and has nutrition, anti-wrinkle and tenderness. skin effect. Molecular weights above 2 million Da are generally used to store water, moisturize, and protect against ultraviolet rays; 1.2 to 1.6 million Da are the most commonly used and most cost-effective sodium hyaluronate; 200,000 to 400,000 Da are based on conventional molecular weights and are reduced through enzymatic hydrolysis Its molecular weight increases its fluidity, allowing it to exert a better moisturizing effect in the essence; those with a molecular weight of less than 10,000 Da can penetrate deep into the stratum corneum of the skin to achieve deep hydration.

When the dosage of sodium hyaluronate is generally above 0.1%, the molecules will fold and form a continuous three-dimensional network, which will produce various physiological effects. The data shows that 0.1% sodium hyaluronate has a moisturizing effect.

Sodium hyaluronate skin care benefits

①Moisturizing

Sodium hyaluronate is highly hydrophilic, with the highest moisture absorption capacity at low relative humidity (33%) and the lowest moisture absorption capacity at high relative humidity (75%). Because of this unique property, it It can adapt to the skin's needs for cosmetic moisturizing in different seasons and under different environmental humidity.

It can form a moisturizing film on the surface of the skin, effectively locking in moisture and increasing the water content of the skin. As a moisturizer, sodium hyaluronate is rarely used alone and is often used in conjunction with other moisturizers.

②Repair

If your skin is affected by sun exposure, ultraviolet rays, etc., and becomes red, black, or peeling, or if you have eczema or allergic dermatitis, you need the powerful blessing of sodium hyaluronate. Because it can promote the proliferation and differentiation of epidermal cells, stimulate cell regeneration and scavenge oxygen free radicals, promote the repair of damaged tissues, promote skin regeneration in injured areas, and accelerate wound healing, its prior use also has a certain preventive effect.

③Anti-wrinkle

In our human body, 50% of sodium hyaluronate exists in the dermis of the skin. Sodium hyaluronate + collagen + elastin together form the skin elastic network, maintaining the stability and elasticity of the skin tissue. As age increases, the hyaluronic acid content in the skin decreases and collagen is lost, which weakens the skin's water-retaining function and causes wrinkles.

Sodium hyaluronate aqueous solution has strong viscoelasticity and lubricity. When applied to the skin surface, it can form a moisturizing and breathable film to keep the skin moist and shiny. Small molecule hyaluronic acid can penetrate into the dermis, promote blood microcirculation, facilitate the absorption of nutrients by the skin, and play a role in beauty and anti-wrinkle.

④Nutrition

Sodium hyaluronate is a biological substance inherent in the skin, and exogenous sodium hyaluronate supplements the endogenous sodium hyaluronate in the skin. Sodium hyaluronate with a smaller molecular weight is more easily absorbed into the bloodstream by the human body and penetrates into the dermis, thereby replenishing the hyaluronic acid content of the skin and relieving dry skin. It can also promote the supply of skin nutrients and the excretion of waste, thereby preventing skin aging. , plays a role in beautifying and nourishing the skin.

⑤Protection

Sodium hyaluronate is a high-molecular polymer with strong lubrication and film-forming properties. After being applied to the skin, it can form a thin film on the skin surface, making the skin feel smooth and moist, and visually giving people a sense of smoothness and moisture. It protects the skin with plumping and elastic effects.

⑥Thickening

Sodium hyaluronate has a high viscosity in aqueous solution, and its 1% aqueous solution is gel-like. It can be added to cosmetics to thicken and stabilize it.

Chemically speaking, sodium hyaluronate is the sodium salt form of hyaluronic acid;

From the perspective of product sales, sodium hyaluronate is a common form of commercial hyaluronic acid;

From the perspective of skin care, sodium hyaluronate has a strong hydrating and moisturizing effect. Depending on its molecular weight, the way of hydrating and moisturizing is also different.

Application of sodium hyaluronate

Application in joint diseases

When osteoarthritis or rheumatoid arthritis and other infectious and non-infectious joint diseases occur, the production and metabolism of sodium hyaluronate in the joints are abnormal, the concentration and molecular weight are significantly reduced, and the cartilage is degraded and destroyed, resulting in Physiological dysfunction. Viscoelastic supplement therapy restores the lubrication function of synovial fluid by supplementing exogenous sodium hyaluronate, which can promote cartilage repair and improve joint function.

Supplementing exogenous sodium hyaluronate can help repair the damaged barrier and prevent further damage and loss of bone matrix; improve the physiological function of synovial fluid under pathological conditions, enable it to lubricate, reduce friction caused by joint movement and tissue sliding, and increase range of motion of the joint; inhibits the excitability of pain receptors and sensory fibers located in the synovium and subsynovium, relieving joint pain; sodium hyaluronate adhering to the surface of articular cartilage and synovial tissue is effective against bacteria, toxins, and immune complexes, etc. The invasion acts as a protective barrier to protect cartilage and synovium from destruction.

Application in the treatment of dry eye syndrome

Sodium hyaluronate has good biocompatibility. It can increase the viscosity of the drug while ensuring that the eyelids can blink easily, making it a good carrier for eye drops. Eye drops containing hyaluronic acid can make the naturally occurring sodium hyaluronate on the ocular surface form a film to cover the surface of the corneal epithelium. The corneal epithelium has specific binding sites for sodium hyaluronate. Medications containing sodium hyaluronate can last for a long time. Retaining on the ocular surface facilitates long-term and effective absorption of the drug by the eye tissue.

When used to treat dry eye syndrome, the specific functions of sodium hyaluronate are: prolonging the break-up time of the tear film, relieving symptoms such as dry eyes, pain, itching, burning, foreign body sensation, etc., stabilizing the tear film; forming a layer on the cornea. A protective film promotes the regeneration of corneal cells and accelerates the healing of corneal ulcers; covers pain receptors to moisturize, lubricate, resist inflammation, and promote repair, relieve local eye irritation caused by drugs, and make patients feel comfortable; absorbs and retains moisture , enhance the water retention performance of the corneal surface and increase the moisturizing properties of the cornea.

Application in facial cosmetic surgery

As age increases, the body's ability to self-synthesize hyaluronic acid gradually decreases, and the hyaluronic acid and water content in the skin decrease, causing skin aging, sagging and wrinkles. Therefore, hyaluronic acid is very useful in treatments for increasing tissue volume and improving facial aging. popular. Exogenous sodium hyaluronate that has not been cross-linked is metabolized and decomposed in the liver, with a half-life of about 1 to 2 days. Therefore, as a skin and soft tissue filler, sodium hyaluronate must be cross-linked to ensure its maintenance in the human body. Time, and the cross-linking modification methods of sodium hyaluronate in different products are different. As a skin soft tissue filler, hyaluronic acid is mostly used to fill subcutaneous or deep facial tissues, modify facial contours or repair aging and sunken skin, so as to achieve facial aesthetics and youthfulness. transformation effect.

Application in cosmetics

As a natural moisturizer, sodium hyaluronate has been widely used in the production of cosmetics. It plays a unique role as a moisturizing factor in cosmetics. Compared with traditional moisturizers, sodium hyaluronate has a higher moisturizing effect and is non-greasy. Disadvantages such as irritation and clogging of skin pores. When it is added to cosmetics and applied to the skin surface, it will form a viscoelastic transparent hydration film. This film has a good water retention effect, just like sodium hyaluronate naturally existing in the intercellular matrix, it can increase The moisture of the stratum corneum of the skin is closely related to the maintenance of skin health and the defense function against external stimuli. Sodium hyaluronate can also penetrate into the dermis and regulate skin metabolism, thus playing a role in anti-wrinkle and beauty care.

Application in food

At present, sodium hyaluronate is widely used in the fields of medical beauty and daily use, but it is still in its infancy in the food industry, because many domestic consumers believe that sodium hyaluronate is active in the medical beauty industry and can only be used externally on the human body. Because of their preconceived cognitive limitations, they do not believe that consuming sodium hyaluronate products can be effective.

At present, many developed countries have approved the use of sodium hyaluronate as a common food additive, and have had practical experience for a certain period of time. In my country, the application of sodium hyaluronate in food is mainly focused on health foods. In the research and development of general foods, sodium hyaluronate is often combined with other ingredients to work together. In 2021, my country will include sodium hyaluronate in the list of new resource food ingredients, and it will develop in the general food industry.

Test report on sodium hyaluronate

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