Tetrahydropalmatine

What Is Tetrahydropalmatine?

Tetrahydropalmatine (THP) is an alkaloid extracted from the dried tuber of Corydalis yanhusuo, a plant of the genus Corydalis of the family Papaveraceae. However, it has poor water solubility, low solubility, is easily metabolized in the body, and its oral absorption bioavailability is only 6.59%. It is highly soluble in ether, chloroform, soluble in ethanol, and almost insoluble in water or alkaline solutions. Its hydrochloride and sulfate are both soluble in water and are racemic. The effective one is the levorotatory isoform, named cranial pain dine. These physical and chemical properties limit the wide application of tetrahydropalmatine. It has multiple pharmacological activities such as sedation, analgesia, anti-myocardial ischemia, anti-thrombosis, inhibition of gastric acid secretion, anti-arrhythmia, and myocardial ischemia/necrosis protection.

Product Details Tables

What Are The Functions?

Analgesia

Tetrahydropalmatine has a significant analgesic effect, especially suitable for treating persistent and chronic dull pain. It helps relieve various pain symptoms such as headaches, chest pain and dysmenorrhea by acting on the central nervous system.

Sedation and hypnosis

This ingredient has a central sedative effect, which can improve sleep quality and reduce dreaming. It is especially suitable for insomnia caused by pain.

Improving microcirculation

It can reduce the aggregation of red blood cells and improve the deformability of red blood cells, thereby reducing blood viscosity and improving blood fluidity, which helps to maintain normal microcirculation perfusion.

Anti-gastric ulcer

This ingredient also shows a certain anti-gastric ulcer effect, which can reduce the secretion of gastric juice and gastric acid, and help treat gastric ulcers.

Muscle relaxation

It also has a muscle relaxant effect and can be used to treat muscle tension and pain.

A New Mechanism of Tetrahydropalmatine(THP)

Angiogenesis is the process of endothelial cells forming new blood vessels. It is an adaptive response of vascular endothelial growth factor (VEGF) to nutrients or hypoxia during exercise or ischemia. THP is the index component of THP and has significant sedative, hypnotic and analgesic effects. It can block calcium channels, inhibit pathogens and conditioned reflexes, and protect brain tissue and cardiovascular system.

Through pharmacological experiments and DESI-MSI spatial metabolomics and GC-MS non-targeted metabolomics, it was identified as a trigger factor for promoting angiogenesis in chicken embryo chorioallantoic membrane in vivo and multiple endothelial cell models in vitro.

1. Molecular docking and research framework diagram

Molecular docking shows that it can be well docked with VEGFR2

2. THP induces angiogenesis in a dose-dependent manner

The angiogenic effect of THP and gastrodin is mainly manifested in an increase in the number and area of ​​blood vessels. The higher its concentration, the more obvious the angiogenesis. PCR detection found that THP and gastrodin promoted the mRNA level of VEGFR2.

3. THP promotes proliferation, tube formation and migration in vitro

4. Non-targeted metabolomics reveals changes in metabolic pathways regulated by THP

5. Mechanistic verification of THP on arginine biosynthesis

Decreases citrulline and arginine succinate synthetase, increases nitric oxide, but does not affect arginine. In vitro cell experiments showed that THP reduced fumarate and arginine and increased VEGFR2 protein levels compared with the control and model groups. At the same time, THP significantly reduced t-BHP-induced oxidative stress.

THP is a pro-angiogenic trigger by regulating arginine biosynthesis. It can sequentially affect the flow of citrulline to arginine, arginine biosynthesis and endothelial VEGFR2 expression, thereby promoting angiogenesis. These results indicate that THP is a potential pro-angiogenic lead compound.

Applications

Health products and cosmetics

Tetrahydropalmatine is also used as a main ingredient in the health products and cosmetics industry. In particular, its anti-inflammatory and antioxidant effects can be used to make skin care products and health products to help improve skin condition and regulate human physiological functions.

Medicine

Due to its analgesic, anti-inflammatory and antioxidant pharmacological activities, it is widely used to treat a variety of diseases. It is mainly used to prepare analgesics, such as oral liquids, capsules, patches, etc., for the treatment of headaches, visceral pain caused by digestive system diseases, etc.

Formulation Of Tetrahydropalmatine

Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Tetrahydropalmatine and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

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