TUDCA Powder

Do You Know TUDCA Powder?

TUDCA Powder (Tauroursodeoxycholic acid), commonly referred to as TUDCA, is a water-soluble (hydrophilic) bile acid found abundantly in bear bile and the primary component of synthetic bear bile. It is a conjugated bile acid found extensively in the bile of humans and various animals and exhibits numerous physiological and pharmacological effects. It has significant liver-protecting properties, including reducing oxidative stress, inhibiting cell apoptosis, and alleviating inflammatory responses, thereby promoting liver cell recovery and regeneration.

YTBIO: Providing High-Quality TUDCA Powder and Services

High-quality nutritional supplements are crucial to your health journey. YTBIO specializes in providing high-quality TUDCA Powder.

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com

What Are The Benefits Of TUDCA Powder?

Dissolving Cholesterol Gallstones

It increases the bile acid content in bile, reduces cholesterol saturation, and promotes the gradual dissolution of cholesterol gallstones.

Improving Cholestasis

It promotes bile secretion and excretion, reduces bile accumulation in the liver, and protects liver cells from damage by toxic bile acids. It is used to treat cholestatic liver diseases, such as primary biliary cholangitis.

Cytoprotective Effects

It has anti-inflammatory, antioxidant, and anti-apoptotic effects, reducing cellular stress and damage, and has potential protective effects against neurodegenerative diseases and cardiovascular diseases.

Drug Effects

TUDCA Powder has antispasmodic, anticonvulsant, anti-inflammatory, and gallstone-dissolving effects. Tauroursodeoxycholic acid, a modern synthetic drug, is a conjugated bile acid formed by the condensation of the carboxyl group of ursodeoxycholic acid and the amino group of taurine. Tauroursodeoxycholic acid capsules are already available overseas and were approved for sale in China as an imported drug in 2007. They are primarily used clinically to treat cholesterol gallstones, primary sclerosing cholangitis, primary biliary cirrhosis, and chronic hepatitis C.

TUDCA Powder Research in Pets

1. TUDCA Powder can improve digestion and absorption in pets. Bile acid secretion: It stimulates the liver to synthesize primary bile acids in dogs and cats, enhancing the emulsification of dietary fat and improving the intestinal absorption of lipids (including triglycerides and cholesterol) and fat-soluble vitamins (A/D/E/K). Pancreatic lipase activation: By regulating the intestinal alkaline environment, it significantly increases pancreatic lipase activity (canine studies have shown a 12%-18% increase in the rate of lipolysis).

2. Regarding hepatobiliary protection, it alleviates cholestasis by downregulating the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, and reducing the accumulation of toxic bile acids (such as lithocholic acid) in hepatocytes in dogs and cats. Hepatocyte repair: Inhibits hepatocyte apoptosis by activating the PI3K/Akt signaling pathway (clinical data show an average 43% decrease in ALT levels in cats with fatty liver disease after 4 weeks of treatment).

3. Improved intestinal function and anti-inflammatory effects: Targets the farnesoid X receptor (FXR), inhibits the nuclear factor kappa B (NF-κB) pathway, and reduces the release of intestinal proinflammatory factors IL-6 and TNF-α. Mucosal barrier repair: Increases the expression of tight junction proteins (ZO-1, occludin), reducing increased intestinal mucosal permeability caused by oxidative stress.

The Role of TUDCA Powder in Anti-Aging and Health Improvement

Aging is a key risk factor for numerous age-related diseases, such as type 2 diabetes, osteoporosis, Alzheimer's disease, and cancer, placing a significant burden on society. Therefore, exploring methods to reduce the incidence of these diseases and improve overall health is of paramount importance.

Bile acids are naturally occurring metabolites and the main component of bile, primarily concentrated in the enterohepatic circulation system. They can be divided into primary and secondary types and play a central role in regulating lipid and glucose metabolism, as well as other metabolic processes.

Previous studies have shown that a secondary bile acid called lithocholic acid (LCA) can extend the lifespan of yeast. TUDCA (tauroursodeoxycholic acid) powder is also a naturally occurring secondary bile acid, synthesized in the liver by combining UDCA (ursodeoxycholic acid) with taurine. However, the specific effects of TUDCA on lifespan and healthspan have been unclear.

On September 24, 2024, a study from the Nanhu Laboratory of the National Center for Biomedical Analysis was published in the journal Science China Life Sciences. The paper, titled "Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extend healthy lifespan," demonstrated that supplementation with TUDCA significantly extended the lifespan of nematodes and improved their health markers.

To investigate whether bile acids have lifespan-extending effects, the researchers tested the effects of various bile acids on the lifespan of Caenorhabditis elegans. They found that only TUDCA significantly extended lifespan. TUDCA Powder was administered continuously from the L4 larval stage until death. Treatment with TUDCA at different concentrations (2.5, 10, and 50 mmol/L) extended the average lifespan of the nematodes by 8.70%, 23.72%, and 19.12%, respectively.

The research team further evaluated the effects of TUDCA on the health of the nematodes. Data showed that TUDCA treatment significantly improved nematode motility compared to the control group, as evidenced by increases in bending frequency and pharyngeal pumping rate. A key finding was that the lifespan-extending effect of TUDCA did not come at the expense of reproductive capacity. Furthermore, the study observed that TUDCA ameliorates aging-related phenotypes in mice.

Mechanistically, the researchers discovered that TUDCA supplementation triggered widespread transcriptional changes in genes associated with anti-aging traits. The molecular mechanism is that TUDCA targets the molecular chaperone protein HSP90, enhancing its protein refolding function. This action, in turn, alleviates aging-induced endoplasmic reticulum (ER) stress, promotes the maintenance of protein homeostasis, and thus enhances resistance to aging.

In summary, this study elucidates the molecular link between endogenous metabolites and protein homeostasis, proposes a novel anti-aging strategy, and opens new avenues for extending lifespan and healthspan.

How Should TUDCA Powder Be Taken?

A variety of dosages have been studied for the benefits of TUDCA. Starting with a TUDCA supplement of 10-13 mg per day, patients with chronic liver disease experienced significant reductions in liver enzymes for three months. Doses of up to 1,750 mg per day have been shown to benefit fatty liver disease and improve muscle and liver insulin sensitivity. Animal studies have shown that doses up to 4,000 mg (the human equivalent) have a positive impact on neuroprotection against age-related memory loss.

Despite these extreme dosages, between 500 mg and 1,500 mg per day appears to be an ideal dose to produce the effects of TUDCA. Most supplements appear to be formulated to contain 100–250 mg of TUDCA per serving, to be taken multiple times daily. As with many of these ingredients, more research is needed to obtain some specific figures.

When should it be taken?

TUDCA can be taken at any time of day, preferably with food to aid absorption. As mentioned above, most supplements have a dosage of 100–250 mg per serving. It's recommended to spread TUDCA dosages throughout the day, taking them 2, 3, 4, or even 5 times daily.

How long does it take for the effects to be felt?

TUDCA powder doesn't work overnight. Studies have shown varying effects after 1, 2, 3, or even 6 months of supplementation. Based on available research, it's safe to assume that at least 30 days (1 month) of supplementation are necessary to see improvements and benefits. However, consistent and long-term use will yield the greatest benefits from TUDCA supplementation.

YTBIO has own factory and R&D team, dedicated to providing you with high-quality TUDCA powder and services. If you have any questions or needs, please contact us and we will respond to you as soon as possible.

Reference:https://link.springer.com/article/10.1007/s11427-024-2717-6