Bulk Paeoniflorin Powder

Do you know Bulk Paeoniflorin Powder？

Peony (scientific name: Paeonia lactiflora Pall.) is a perennial herbaceous plant of the genus Paeonia in the family Paeoniaceae. It is also known as wild peony, wild white peony, and peony flower. It is found in Korea, Japan, Mongolia, Russia, and China. In China, peony symbolizes love, friendship, and farewell. It is one of the oldest cultivated ornamental flowers in China. Its large, beautiful flowers, rich in fragrance, have earned it a reputation as a "flower of beauty" since ancient times. Fresh cut peony flowers last a long time in vases and have a high ornamental value, enjoying a significant international market.

The root of the peony is used medicinally, also known as "white peony." Bulk Paeoniflorin Powder is a monoterpenoid glycoside compound extracted from the root of the genus Paeonia. It has anti-inflammatory, antioxidant, and neuroprotective properties and is widely used in medicine, healthcare, cosmetics, and food.

Paeoniflorin - the main component of peony root extract

The powder extracted from peony root contains the following active ingredients:

The root contains paeoniflorin, oxypaeoniflorin, albiflorin, benzoylpaeoniflorin, paeoniflorigenone, paeonolide, and paeonol; it also contains benzoic acid, carotene, and various tannins. Paeoniflorin is the main component.

Common Extraction Methods

Heating and Reflux Extraction: Utilizing the refluxing effect of the solvent, the plant components are fully dissolved in the solvent, thereby improving extraction efficiency.

Ultrasonic extraction method: It can significantly improve the extraction efficiency. Through orthogonal experimental design, the optimal extraction process conditions can be determined. For example, using 70% ethanol as the extraction solvent, a liquid-to-solid ratio of 200 mL/g, and an ultrasonic extraction time of 30 minutes have been proven to be the optimal conditions for extracting the main components of peony.

Wide range of benefits about Bulk Paeoniflorin Powder

Anti-inflammatory

By inhibiting the release of inflammatory mediators, it reduces inflammation and is used for conditions such as rheumatoid arthritis and osteoarthritis.

Cardiovascular regulation

It can dilate coronary arteries, increase blood flow, and improve cardiovascular function. It also has antihypertensive, anti-lipid, and anti-atherosclerotic effects, helping to prevent and treat cardiovascular disease.

Immunomodulatory

It can enhance immunity and regulate immune system function, offering potential therapeutic value for autoimmune diseases.

Neuroprotective

By preventing oxidative stress, inhibiting astrocyte overactivation, and protecting dopaminergic neurons, it has ameliorative effects on neurological disorders such as Alzheimer's disease, Parkinson's disease, and epilepsy, and can alleviate movement disorders.

In addition, paeoniflorin has been shown to have hypoglycemic, organ-protective, analgesic, sedative, anti-ulcer, and hypoxia-resistant effects.Overall, paeoniflorin has a wide range of applications in anti-inflammatory, cardiovascular, neuroprotective, and immunomodulatory settings.

Applications of Bulk Paeoniflorin Powder

Due to its diverse benefits, paeoniflorin has broad application value in various fields.

Medicine

1.Nervous System

Improves brain disorders such as Alzheimer's and Parkinson's disease.

Reduces oxidative damage to brain cells, protects nerve function, and slows memory loss.

2.Cardiovascular

Dilates blood vessels, improves blood circulation, and prevents thrombosis.

Regulates blood pressure and blood lipids, reducing the risk of arteriosclerosis.

3.Digestive System

Anti-inflammatory and anti-ulcer, alleviating symptoms of gastritis and gastric ulcers.

4.Immune System

Regulates immunity and reduces inflammatory responses in autoimmune diseases such as rheumatoid arthritis.

Health Products

1.Immunity Enhancement

Regulates the immune system and enhances disease resistance.

2.Improves blood circulation

Promotes blood flow and prevents blood vessel blockage.

3.Anti-aging

Scavenges free radicals and slows cell aging.

Cosmetics

1.Anti-inflammatory and Repairing

Soothes sensitive skin and repairs damaged skin.

2.Skin Whitening and Brightening

Inhibits melanin production, reduces dark spots, and brightens skin tone.

3.Moisturizing and Antibacterial

Maintains skin hydration and strengthens the skin barrier.

Food

1.Food Additives

Used in beverages, candies, and other products to improve taste and quality.

2.Functional Foods

Developing healthy foods with antioxidant, anti-inflammatory, and immune-boosting properties.

Bulk Paeoniflorin Powder - A Natural Anti-Melanin Ingredient

Plants from the Paeoniaceae family possess numerous benefits and properties for the skin. Among them, Bulk paeoniflorin powder is known for its ability to scavenge free radicals, maintain skin elasticity, and promote skin metabolism. Therefore, it is often added to cosmetics for anti-aging and skin health, typically in creams, eye creams, and serums, aiming to reduce wrinkles and improve skin elasticity and radiance. So, what are its whitening effects?

Research on the regulatory role of paeoniflorin in skin pigmentation suggests that it can reverse the increase in melanin content and tyrosinase activity induced by α-MSH. Furthermore, paeoniflorin can inhibit the activation of cAMP response element binding protein and the expression of TRP-1, TRP-2, and microphthalmia-associated transcription factor proteins in B16F10 cells stimulated by α-MSH.

α-MSH induces melanin production in B16F10 cells

This experimental model utilizes mouse B16F10 cells. To validate the model, a common approach was employed: stimulation with α-MSH and observation of melanin production. The final results showed that the dosage of α-MSH can be determined to be 1 μM. After the model was stimulated externally, significant changes were observed in melanin-related indicators such as MC1R, MITF, TRP-1, and TRP-2, indicating that the experimental model is effective.

Effect of Paeoniflorin on B16F10 Cell Viability

Before testing its efficacy, the researchers first assessed the safety of paeoniflorin. Cell viability testing revealed that paeoniflorin exhibited no cytotoxic effects at concentrations ≤20 μM. Therefore, at this concentration, the ingredient possesses a high safety profile.

Inhibitory Effect of Paeoniflorin on Cellular Melanogenesis

The research team then investigated the whitening mechanism of paeoniflorin. To investigate the anti-melanogenesis effect of paeoniflorin, B16F10 cells were treated with α-MSH (1 μM) for 24 hours and then with paeoniflorin (1, 5, and 10 μM). After treatment with α-MSH, melanin content and tyrosinase activity increased, indicating melanin formation. However, after treatment with paeoniflorin, melanin content and tyrosinase activity decreased in a dose-dependent manner, demonstrating the anti-melanin effect of paeoniflorin. The results showed that cAMP response element binding protein was inhibited in B16F10 cells, and the expression of TRP-1, TRP-2, and microphthalmia-associated transcription factor proteins was downregulated.

Summary

Paeoniflorin, as a natural active ingredient, exhibits significant skin-whitening efficacy. It effectively inhibits α-MSH-induced melanin production by reducing tyrosinase activity, decreasing melanin content, and regulating the expression of key proteins, thereby blocking the melanin synthesis pathway. Furthermore, paeoniflorin is non-toxic to cells at concentrations ≤20 μM, making it highly safe and suitable for use in skincare products. Spot-lightening and brightening products containing paeoniflorin can help improve pigmentation while also exhibiting anti-aging and antioxidant benefits.

YTBIO is committed to providing customers with the highest quality Bulk paeoniflorin powder and services, ensuring that every consumer can enjoy natural, healthy, and high-quality products. If you have any questions or inquiries about our products, please feel free to contact us and we will respond as soon as possible.