Celastrol Powder

What is Celastrol?

Celastrol Powder is mainly derived from Tripterygium wilfordii Hook. f. of the Celastraceae family. It is also found in plants such as Celastrus orbiculatus and Diplococephalum, and is also found in honey. It is a natural corkane-type pentacyclic triterpene, which is famous for its powerful anti-inflammatory and antioxidant properties. It is one of the effective active ingredients of Tripterygium wilfordii, and has multiple pharmacological activities such as anti-rheumatoid arthritis, antioxidant, neuroprotection, and hypoglycemic. It is currently a hot natural product that has attracted widespread attention.

Product Details List

Functions of Celastrol

Anti-inflammatory

It can inhibit inflammation and reduce cell death, thereby protecting the body from inflammation-related diseases.

Antioxidant and anti-obesity

This ingredient has a strong antioxidant capacity, which can help resist oxidative stress and inhibit obesity by increasing sensitivity to leptin.

Improving mitochondrial dysfunction

It can improve neuronal mitochondrial dysfunction caused by cerebral hemorrhage and promote the recovery of neuronal mitochondrial function.

Weight loss effect

It can enhance the body's leptin sensitivity, reduce food intake, and block the reduction of energy consumption, thereby playing a weight loss role.

Neuroprotection

Celastrol Powder has a protective effect on the nervous system and can improve the symptoms of neurodegenerative diseases.

Effect of tripterygium wilfordii on TNF-α-induced rheumatoid arthritis and its mechanism

Effect on FLS cell viability

CCK-8 assay was used to detect its effect on FLS cell viability. FLS cells were treated with different concentrations for 24h. When the concentration was ≥80μmol/L, the viability of FLS cells was significantly reduced, and with the continuous increase in concentration, the cell survival rate decreased in a dose-dependent manner, indicating that this concentration had a significant inhibitory effect on the survival rate of FLS cells.

Effect on the proliferation of activated FLS cells

Under the pathological state of RA, FLS is abnormally activated and proliferates abnormally. TNF-α (10ng/mL) was used to activate normal FLS to turn it into RA-FLS. Compared with the blank group, the FLS in the model group was activated, showing significant proliferation of RA-FLS. It shows that tripterygium wilfordii can significantly inhibit the proliferation of RA-FLS and inhibit the progression of RA at 10-40μmol/L.

Effects on inflammatory cytokines and matrix metalloproteinases in activated FLS

When its concentration was 40μmol/L, it could significantly inhibit the release of inflammatory cytokines (P<0.000 1, P<0.001). In the range of 10~40μmol/L, it could significantly inhibit the production of related matrix metalloproteinases (MMP-1 and MMP-3).

Effects on the expression of apoptotic proteins in activated FLS

After 2h of treatment, the protein expression level of the high-dose group (40μmol/L) was significantly increased.

Effects on ERK1/2 and phosphorylated ERK1/2 in activated FLS

Compared with the TNF-α model group, both showed activation of phosphorylated ERK1/2 protein.

Conclusion, the mechanism of action of inhibiting TNF-α-induced rheumatoid arthritis may be related to its inhibition of the activation of phosphorylated ERK-related pathway proteins and the promotion of apoptosis of RA-FLS.

Application

Food

As a natural pigment, it is widely used in meat products, beverages, pastries and other fields, replacing synthetic pigments and becoming the mainstream. In meat products, it can be used to improve the color of meat and enhance the sensory quality of the product; in beverages and pastries, it helps to increase the color and nutritional value of the product.

Health products

Due to its various biological activities, such as antioxidant and immunomodulatory, it is used to develop new health products to meet the market demand for health products.

Weight loss products

Because of its anti-obesity properties, it is developed and used in weight loss products to help consumers achieve their weight loss goals.

Cosmetics

With its natural color and safety, it has become the preferred pigment for many cosmetic brands. In the fields of skin care products, makeup, etc.

Medicine

Due to its anti-inflammatory and analgesic effects, its application in pharmaceutical preparations is increasing, such as for the preparation of anti-inflammatory drugs, analgesics, etc.

Feed

It is also used in animal feed to improve the health and production efficiency of animals.

Formulation Of Celastrol

Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Celastrol Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

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