Cornus Officinalis Extract

What Is Cornus Officinalis Extract？

Cornus Officinalis Extract is an active ingredient extracted from the seeds or pulp of the cornus plant. It is rich in various compounds, such as cornus tannin, linalool oxide, methyl eugenol, moro glycoside, ursolic acid, saponin, etc. These ingredients give it rich pharmacological effects. It has the effects of nourishing the liver and kidney, anti-inflammatory, anti-shock, and cardiotonic. It is favored by people for its unique medicinal value. It contains rich active ingredients and has many health benefits, and is loved by consumers. Due to its rich pharmacological activity and broad application prospects, it has important application value in the fields of medicine, food, cosmetics, etc.

Main components of Cornus Officinalis Extract

Iridoid glycosides

Loganin: has multiple biological activities such as anti-inflammatory, antibacterial and antioxidant.

Morroniside: has neuroprotective, anti-inflammatory and antioxidant effects.

Organic acids

Gallic acid: has antioxidant, anti-inflammatory and antibacterial effects.

Malic acid: naturally present in many fruits, with a sour taste.

Polysaccharides: Cornus officinalis polysaccharides have biological activities such as immunomodulation and antioxidant.

Tannin: has astringent, hemostatic and anti-inflammatory effects.

Other ingredients

Saponin: has multiple biological activities such as anti-inflammatory and antibacterial.

Vitamins: such as vitamin A and vitamin C, have antioxidant and immune-enhancing effects.

Trace elements: such as calcium, iron, zinc, etc., are beneficial to human health

Benefits of Cornus Officinalis Extract

Enhance immunity

Cornus polysaccharide components can effectively inhibit spleen atrophy in immunocompromised mice and improve the phagocytic ability of macrophages, thereby enhancing immunity.

Antioxidant

Cornus Officinalis Extract has potential antioxidant activity and can inhibit endotoxin-induced inflammatory and oxidative reactions by activating the NRF2/HO-1 signaling pathway.

Anti-inflammatory and antibacterial

It has an inhibitory effect on a variety of pathogens, has anti-inflammatory effects, and helps treat inflammatory-related diseases such as hepatitis and nephritis.

Anti-aging

The polyphenol components have antioxidant effects, help resist free radical damage, delay the aging process, and improve skin conditions.

Hypoglycemic

It can lower blood sugar levels, has a certain auxiliary therapeutic effect on diabetic patients, and helps improve diabetic complications.

Cardiovascular protection

It helps to enhance myocardial contractility, improve cardiac function, and has a certain preventive and therapeutic effect on arrhythmias. In addition, it can also inhibit platelet aggregation and reduce the risk of thrombosis.

Maintain healthy blood sugar levels

Morroniside in Cornus officinalis can significantly reduce serum glucose concentration and effectively inhibit the expression of enzymes related to blood sugar concentration, thereby helping to maintain healthy blood sugar levels.

Neuroprotection

Cornus officinalis iridoid glycosides (CIG) promote learning and memory ability and BDNF protein expression in the hippocampus of gerbils with cerebral ischemia. At the same time, CIG can reduce the number of neuronal deaths in the hippocampus of adult SD rats with cut fimbria fornix. Its mechanism of action may be related to upregulating apoptosis inhibitors and downregulating apoptosis promoters. The active ingredients of Cornus officinalis can also reduce brain damage caused by cerebral ischemia-reperfusion by inhibiting free radical damage and inflammatory response, reducing calcium overload, and inhibiting apoptosis.

Applications of Cornus Officinalis Extract

Food

Food additives: As natural food additives, it is used to improve the nutritional value and flavor of food, such as adding it to candies, cakes, beverages, etc.

Seasonings: It can be used to develop seasonings with health functions, such as soy sauce, vinegar, etc.

Health products

It is made into various health foods, such as capsules, tablets, oral liquids, etc., which are used to enhance immunity, resist fatigue, improve sleep, regulate blood sugar and blood lipids, etc.

Functional beverages: Added to functional beverages, it provides additional health benefits, such as anti-aging, anti-oxidation, and improving physical strength.

Daily chemicals

Skin care products: It has antioxidant, anti-inflammatory, and whitening effects, and is used to develop various skin care products, such as creams, essences, and masks, to improve skin conditions and delay skin aging.

Hair care products: Added to shampoo and conditioner, it has the effects of promoting hair growth, preventing hair loss, and improving scalp health.

Daily necessities: Added to daily chemical products such as toothpaste and mouthwash, it has antibacterial, anti-inflammatory, and fresh breath effects.

Feed

It can be used to develop feed additives with health functions to improve the immunity and production performance of livestock and poultry.

Medicine

It is used to develop new pharmaceutical products with anti-inflammatory, antibacterial, antioxidant and other pharmacological effects.

Preparation of Cornus Officinalis Extract

(1) Extract the cornus officinalis medicinal material with ethanol, filter and concentrate until there is no alcohol taste;

(2) The concentrate is allowed to stand at low temperature for more than 24 hours, filter and separate the solid and clear liquid, wash the solid with hot water until it is neutral, and combine the washing liquid with the clear liquid;

(3) Dissolve the solid with ethanol by heating, filter, add alkaline solution to the filtrate, filter to remove fat-soluble impurities, add acid solution to the filtrate to adjust the pH to 1-2, precipitate white to yellow solid, filter, and recrystallize the solid with ethanol to obtain extract A;

(4) Put the lower clear liquid on a macroporous resin column, wash impurities with water and 5% ethanol, elute with ethanol gradient, collect the eluate, and concentrate to dryness to obtain an extract;

(5) Dissolve the extract with ethanol, filter, concentrate the filtrate, and vacuum dry to obtain extract B; Extracts A and B are evenly mixed to obtain cornus officinalis extract.

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Cornus Officinalis Extract and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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