Glabridin Powder

Do You Know About Glabridin Powder?​​​​​​​

Glabridin powder is a natural flavonoid compound extracted from the root of the licorice plant. It is hailed as "whitening gold" due to its remarkable whitening effects. Its outstanding antioxidant capacity is comparable to SOD enzymes, effectively neutralizing free radicals and reducing photoaging damage. It also possesses anti-inflammatory properties, soothing sensitive skin. Based on these properties, glycyrrhizin has become a core ingredient in high-end whitening skincare formulas. Through innovative technologies such as nano-encapsulation, its recommended concentration in cosmetics can be precisely controlled within the range of 0.001%-3%, achieving a perfect balance between efficacy and safety.

YTBIO: Providing High-Quality Glabridin Powder and Services

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com 

Core Efficacy and Mechanism of Action of Glabridin Powder

Whitening Mechanism

Glabridin powder achieves highly effective whitening through a triple pathway:

· Directly inhibits tyrosinase activity, blocking a key step in melanin synthesis

· Interferes with signal transduction pathways within melanocytes

· Accelerates epidermal pigment metabolism. Clinical data shows that continuous use at a 0.04% concentration for 28 days can increase skin brightness by 52.17%.

Antioxidant Defense System

· Scavenges various free radicals, with antioxidant efficacy comparable to SOD enzymes

· Reduces UV-induced oxidative damage

· Protects cell membranes and proteins from oxidative stress

Anti-inflammatory and Soothing Properties

· Inhibits the release of key inflammatory factors

· Significantly improves skin redness symptoms (clinically verified improvement rate of 87.5% after 2 months)

· Enhances skin barrier integrity

Antibacterial Regulation Function

· Selectively inhibits specific pathogenic bacteria

· Maintains skin microecological balance

· Prevents bacterial-induced inflammatory responses

The Diverse Applications of Glabridin Powder

High-End Skincare: As a star whitening ingredient, glabridin powder has become a core ingredient in high-end skincare products such as serums and creams. Its unique value lies in its ability to whiten while simultaneously soothing, making it particularly suitable for sensitive skin. By precisely controlling the concentration (typically 0.001%-0.1%), it can effectively improve uneven skin tone and fade acne scars without causing skin irritation.

Professional Repair: Thanks to its excellent anti-inflammatory properties, glabridin is used in professional repair product lines. Clinical data shows that it can significantly improve skin redness, making it an important ingredient in special care products for sensitive skin issues such as rosacea and steroid-induced dermatitis.

Oral Aesthetics: Emerging oral aesthetic products are actively exploring the application potential of glabridin. Preliminary studies suggest that it may achieve skin tone improvement from the inside out through a systemic regulatory mechanism. Although clinical evidence in this area still needs further refinement, it has already shown great promise.

In the pharmaceutical research and development field, the anti-inflammatory and antioxidant properties of glabridin are attracting research attention. Current studies are exploring its potential application in the adjunctive treatment of inflammatory skin diseases, providing direction for the future development of novel skin treatments.

In the luxury skincare field, due to its complex extraction process and low yield, glabridin is renowned in the industry as "whitening gold." This characteristic naturally makes it a preferred ingredient for luxury skincare brands, used in scientific formulations with other rare ingredients to build the efficacy system of top-tier skincare products.

These cross-sectoral applications fully demonstrate the transformation and upgrading of glabridin powder from a single whitening function to a multifunctional skincare ingredient. Its unique efficacy characteristics provide a high-quality raw material choice for product innovation in different market segments.

Glabridin Powder: A Precious Whitening Ingredient

Research Progress on the Cosmetic Efficacy of Glabridin

Glabridin powder, as a natural whitening active ingredient, has had its mechanism of action fully verified through systematic experiments. In whitening pathway studies, it was found that this ingredient can effectively inhibit the activity of both T1 and T3 tyrosinase subtypes, while also showing significant inhibitory effects on monophenolase and diphenolase. Experimental data show that it can effectively block key steps in melanin production within a concentration range of 0.1-1.0 μg/mL.

(a) Effects of glycyrrhizin on tyrosinase activity and (b) DNA synthesis in B16 cells

(Left) Inhibition curve of glycyrrhizin on tyrosinase monophenolase (Right) Effect of glycyrrhizin on diphenolase homeostatic activity

In antioxidant research, glabridin exhibits excellent free radical scavenging ability. It demonstrates a powerful anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, effectively protecting biomolecules such as low-density lipoprotein from oxidative damage. Studies have confirmed that when the concentration reaches 40-60 μmol/L, the inhibition rate of LDL oxidation can reach 90%, and its ability to scavenge oxygen free radicals is comparable to that of SOD enzyme, with antioxidant properties close to those of vitamin E.

Furthermore, Glabridin exhibits multiple synergistic effects: it not only inhibits the activity of dopachrome tautomerase and dihydroxyindole carboxylic acid oxidase, but also possesses significant anti-inflammatory properties. These experimentally verified characteristics make it a multifunctional cosmetic ingredient that combines high efficacy and safety, providing a solid scientific foundation for the development of comprehensive skincare products.

Application Breakthroughs and Technological Challenges 

Glabridin powder, a recognized multi-functional active ingredient in modern skincare, is valuable for its ability to achieve a unified effect of whitening, sun protection, and anti-aging. This ingredient not only significantly enhances the skin's antioxidant defense capabilities but also possesses excellent photoprotective properties, effectively blocking UV damage. In practical applications, only a concentration of 0.001-0.1% is needed to achieve significant efficacy, without the need for additional antioxidants, ensuring a simplified formulation and reducing potential skin irritation risks.

However, the application of this ingredient still faces two major technological bottlenecks: firstly, its extremely low water solubility (0.1 mg/L) and high lipid solubility (lg P=4.85) limit its bioavailability; secondly, its chemical structure is extremely sensitive to environmental factors, especially prone to degradation and inactivation under light conditions. These characteristics pose significant challenges to its stability in formulations and its transdermal absorption efficiency.

Current technological breakthroughs focus on dosage form innovation. Improving the solubility and stability of glycyrrhizin powder through structural modification and carrier technology has become a core research direction in the industry. Advances in these technologies will propel it from the laboratory to wider market applications, providing crucial technical support for the development of next-generation multifunctional skincare products.

FAQ

Q: What are the core specifications of YTBIO's Glabrini raw material?

A: We offer standardized Glycyrrhiza glabra extract, primarily with a 40% Glabrini content, and also provide different purity levels such as 35% and 98% to meet diverse customer needs.

Q: What are the main efficacy characteristics of Glabrini?

A: Our Glabrini raw material has multiple skincare benefits:

Excellent whitening effect: Effectively reduces melanin production by inhibiting tyrosinase activity.

Powerful antioxidant capacity: Scavenges free radicals and delays skin aging.

Natural sun protection properties: Absorbs ultraviolet rays and enhances the skin's photoprotective ability.

Anti-inflammatory and soothing effects: Suitable for sensitive skin.

Q: How does YTBIO guarantee the quality of its raw materials?

A: We have established a comprehensive quality assurance system:

Our production facilities are certified by cGMP and ISO9001 quality management systems.

We hold ISO22000 and HACCP food safety management system certificates.

We have obtained EU&NOP organic certification, Kosher, BRC, Halal, and other specialized certifications.

We employ advanced testing methods to ensure the accuracy and stability of our ingredients.

Q: Can you provide samples?

A: Of course. We are happy to provide you with free samples so you can evaluate the quality of our products. Samples are free, but you will be responsible for the shipping costs.

Q: What is the delivery time? How is logistics handled?

A: After receiving payment, we typically prepare and ship your product within 3-5 business days. We can arrange ocean freight, air freight, or international express delivery based on your needs. We work with trusted logistics partners to ensure safe and timely delivery of your goods to your designated port or address.

Q: How do I get started with YTBIO?

A: We are eager to collaborate with major global brands and partners. Please visit the YTBIO official website and submit your specific requirements through the "Contact Us" page. Our professional team will promptly provide you with detailed product technical documents (TDS), certifications (COA), and competitive solutions.