Paeoniflorin Powder

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Paeoniflorin is a common monoterpenoid glycoside found in plants of the Paeoniaceae family, and is also a major component of traditional Chinese medicines such as white peony root, red peony root, and peony bark. Its active ingredients and quality control standards are well-documented, and it possesses a variety of pharmacological effects and uses. Paeoniflorin exhibits various pharmacological effects, including sedation, anti-inflammation, analgesia, and cognitive enhancement, and is widely used in the clinical treatment and basic research of neurological diseases and neurodegenerative disorders such as Alzheimer's disease, stroke, depression, and epilepsy.In recent years, significant progress has been made in the research of pharmacological effects of peoniflorin, including antidepressant, anti-inflammatory, analgesic, hepatoprotective, neuroprotective, immunomodulatory, and prevention and treatment of diabetic complications.

Since 2014, YTBIO have been a professional plant extract manufacturer, employing advanced high-performance liquid chromatography (HPLC) extraction technology to produce high-purity paeoniflorin powder. We use premium white peony root (Paeonia lactiflora), and our production process complies with GMP certification standards, ensuring uniform particle size of 80-120 mesh. Our annual production capacity reaches 50 tons, with moisture content below 5% and heavy metal content far below EU Pharmacopoeia standards. Each batch undergoes rigorous third-party testing, including pesticide residue, microbial contamination, and active ingredient verification.

What are the Benefits?

1. Antioxidant effect: It can scavenge free radicals, reduce oxidative damage, and protect the skin from environmental factors such as ultraviolet rays and pollution.

Source: Huang Chengzefang, Liu Bo, Shen Changhong, Yang Fangdi, Liu Fei, Dai Jinxin, Zhang Ruoqi. Research progress on the antioxidant stress effect of paeoniflorin [J]. Chinese Traditional and Herbal Drugs, 2025, 56(12): 4499-4515

2. Anti-inflammatory effect: It can inhibit inflammatory reactions and reduce symptoms of skin inflammation such as redness, swelling, and itching.

3. Promote collagen synthesis: It can promote collagen synthesis and enhance skin elasticity and firmness.

4. Inhibit melanin production: It can inhibit melanin production and reduce the occurrence of pigmented skin diseases such as spots and freckles.

5. Moisturizing effect: It can increase the moisture content of the skin, improve the skin's water retention capacity, and make the skin softer and smoother.

6. Anti-inflammatory effect

Early researchers found that paeoniflorin significantly inhibited the expression of chemokine mRNA in human dermal microvascular endothelial cells (HMEC-1) induced by TNF-α and reduced the secretion of chemokines in the culture supernatant; they also found that paeoniflorin inhibited nuclear transcription. Factor-κB (NF-κB) is transported to the nucleus, indicating that paeoniflorin has the anti-inflammatory ability to resist TNF-α-induced chemokine production and leukocyte migration, and its mechanism is related to inhibiting the NF-κB and ERK pathways. It is shown that paeoniflorin has anti-inflammatory effects in vitro and can be used as a candidate drug for the treatment of inflammatory skin diseases.

7.Analgesic effect

Paeoniflorin has an analgesic effect, which is not only effective when used in combination with benzoylaconitine, but also has important value in the independent treatment of various types of pain. Studies have found that the analgesic effect of paeoniflorin may be related to the increase in β-endorphin (β-EP) levels in serum and cerebral cortex and the reduction in the production or release of prostaglandin E2 (PGE2) in the cerebral cortex.

8. Body protection function

1 Protective effect against liver damage

Previous studies have found that paeoniflorin has a certain therapeutic effect on non-alcoholic fatty liver disease, chemical liver injury, radiation liver injury, immune inflammatory liver injury, ischemia-reperfusion liver injury and other diseases, but the mechanism of action has been unclear in recent years. It can be further elucidated, mainly in the aspects of inhibiting inflammatory factors, regulating anti-oxidative stress, regulating immunity and anti-apoptosis. It was found that paeoniflorin can significantly reduce the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the serum of mice, and has a protective effect on liver damage caused by lipopolysaccharide. Studies have found that paeoniflorin has a protective effect on carbon tetrachloride-induced acute liver injury and liver fibrosis. The mechanism may be related to reducing hepatocyte apoptosis, oxidative stress, reducing pro-inflammatory cytokine production, and promoting heme oxygenase- 1 is related to the expression.

2 Neuroprotective effect

Paeoniflorin Powder has obvious protective effects on neurons, neurotoxicity and nerve cell damage. Research in the past 2 years has further clarified this mechanism of action. Studies have found that paeoniflorin inhibits Aβ(1-42)-mediated oxidative stress and hippocampal neuron damage in AD rats by activating the NF-E2-related factor 2/ARE regulatory gene (Nrf2/ARE) pathway. It was found that paeoniflorin can alleviate the loss of neurons caused by tributyltin chloride (TBTC) and reverse the decrease in mitogen-activated protein kinase (MAPK) and JNK levels by inhibiting stress-activated protein kinase (JNK) activity. In addition, it was found that paeoniflorin may prevent or treat neurodegenerative diseases and nerve damage by inhibiting the mitogen-activated protein kinase kinase-4 (MKK4)-JNK signaling pathway.

9. Immunomodulatory effect

Early studies have found that total glycosides of paeony have a therapeutic effect on autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In the past two years, literature has reported that paeoniflorin is the main component that exerts immunomodulatory effects. By exploring the effect of paeoniflorin on the phenotype and function of dendritic cells (DCs), we found that paeoniflorin can significantly inhibit the maturation and function of DCs, providing a basis for the treatment of autoimmune diseases with paeoniflorin. Paeoniflorin was found to reduce lipopolysaccharide (LPS)-induced phosphorylation of interleukin receptor 1-related kinase 1 (IRAK 1) and its downstream proteins, and inhibit the expression of TNF-α and IL-6. This indicates that paeoniflorin inhibits LPS-induced cell activation by inhibiting the IRAK 1/NF-κB pathway in macrophages of MRL/LPR mice, and may be a potential treatment for the autoimmune disease systemic lupus erythematosus. These results suggest that paeoniflorin has dual immunomodulatory effects.

10.Other functions

In addition, Paeoniflorin Powder also has pharmacological effects such as improving sleep, antioxidant, regulating blood lipids, and downregulating estrogen levels in the cerebral cortex of premenstrual syndrome.

Paeoniflorin Powder Characteristics

Superior Quality and Stability

We employ innovative extraction technology to ensure consistent product purity. Under proper storage conditions, this powder maintains stability for 24 months.

Excellent Solubility

The small molecular size ensures rapid dissolution in liquid solutions. This characteristic makes it easy to add to a variety of products.

High Bioavailability

Standardized extraction processes preserve the natural molecular structure. This ensures optimal absorption after consumption.

No Pesticide Residues

We source raw materials from partner farms. Each batch of raw materials undergoes rigorous pesticide residue testing before being released to the market.

Traceable Supply Chain

Each batch of raw materials has complete traceability documentation. From planting to finished product packaging, the entire process is transparent and open.

Applications of Paeoniflorin Powder

This extract has a wide range of uses and applications across numerous industries. Dietary supplement manufacturers add it to capsules, tablets, and powder blends to enhance nutrition. The cosmetics industry also values its efficacy in skincare products, especially in anti-aging and whitening serums. Practical beverage engineers are using it to produce health-focused drinks. Pharmaceutical analysts are studying its potential in various medical applications. The natural products sector is enhancing its traditional value while combining it with modern scientific validation. Food and beverage formulators are adding it to health-oriented products. Veterinary supplement manufacturers are also recognizing its potential benefits in animal health applications.

Why Choose Us?

12 Years of Industry Expertise

Since 2014, we've specialized in natural plant extracts. Our specialized group brings broad information in extraction and quality control.

Comprehensive Certification Portfolio

We hold USDA Natural, EU Natural, FSSC 22000, BRC, and ISO certifications. These qualifications illustrate our commitment to universal standards.

Vertically Coordinates Production

We control the whole supply chain from cultivate organizations to last bundling. This integration guarantees steady quality and competitive pricing.

Advanced Testing Capabilities

Our in-house research facility performs HPLC, UV-Vis, and microbial investigation. Third-party testing gives extra confirmation for your confidence.

Flexible Arrange Quantities

Whether you require test amounts or holder loads, we oblige your needs. Our MOQ arrangements bolster both new companies and set up brands.

Responsive Client Service

Our specialized bolster group answers your questions instantly. We give detailing direction and administrative documentation help.

Contact Us

Ready to source premium quality Paeoniflorin Powder for your business?

Our team at Shaanxi Yuantai Biological Technology Co., Ltd. is here to support your needs.

Email:sales@sxytorganic.com