NMN Powder Bulk

Do You Know About NMN Powder Bulk?

NMN powder bulk (β-nicotinamide mononucleotide, NMN) is a precursor of nicotinamide adenine dinucleotide (NAD) and plays a key role in increasing NAD levels. Consuming NMN powder bulk can alter the composition and activity of the intestinal microbiome, restore mitochondrial function, inhibit the activation of inflammatory pathways, improve metabolism, combat oxidative stress, and reduce inflammation, thereby exerting significant restorative effects in the prevention and treatment of age-related diseases.

β-nicotinamide mononucleotide is found naturally in a variety of foods, including broccoli, cabbage, cucumber peels, and seeds.

YTBIO: Providing High-Quality NMN Powder Bulk and Services

High-quality nutritional supplements are crucial to your health journey. YTBIO specializes in providing high-quality NMN Powder Bulk.

Why choose YTBIO? We hold the following certifications:

- cGMP, ISO9001, and ISO22000 certifications ensure rigorous quality control throughout the entire process;

- BRC and HACCP system certifications ensure product safety and reliability;

- EU and NOP organic, kosher, and halal certifications meet various global standards and dietary requirements.

We specialize in the research, development, and production of natural plant extracts, cosmetic active ingredients, and health foods. We primarily produce plant extracts, health food ingredients, and a variety of end-use products, including capsules, softgels, granular capsules, gummies, tablets, and solid beverages. Our production facilities and equipment meet national standards, and our production processes strictly adhere to GMP requirements. If you have any questions, please feel free to contact us at sales@sxytorganic.com

What Are The Benefits Of NMN Powder Bulk?

β-Nicotinamide mononucleotide (NMN) is a substance that plays a key role in cellular energy metabolism. Its main effects include:

Anti-aging

NMN Powder Bulk can increase NAD+ levels, activate the longevity gene Sirtuins, delay cellular aging, and improve age-related physiological function decline, such as muscle strength and cognitive ability.

Metabolism Regulation

Improves insulin sensitivity and regulates blood sugar and lipid metabolism, helping to prevent metabolic diseases such as diabetes and obesity.

Cardiovascular Protection

It helps improve vascular function, lower blood pressure and cholesterol levels, and reduce the risk of cardiovascular disease.

Neuroprotection

It has a protective effect on the nervous system, may improve memory and cognitive function, and has some potential to prevent neurodegenerative diseases (such as Alzheimer's disease).

Metabolism Enhancement

Promotes mitochondrial function, increases cellular energy production efficiency, relieves fatigue, and enhances physical strength and endurance.

Immunomodulation

It may enhance immune system function and improve immunity by regulating NAD+ levels.

Applications Of NMN Powder Bulk In Disease Treatment

NMN powder bulk improves cognition and memory, and has a therapeutic effect on central nervous system diseases such as Alzheimer's disease (AD) and Parkinson's disease. AD patients experience cognitive impairment and memory loss. Abnormal mitochondrial structure and function are one of the causes of AD. Studies have found that increasing NMN levels in the body increases NAD+ availability, promoting mitochondrial fusion and improving mitochondrial respiratory function. By altering energy transfer and storage during metabolism, NMN prevents the imbalance between oxidation and antioxidant activity, improving cognitive and memory decline in AD caused by the accumulation of amyloid beta (Aβ1-42 oligomers).

NAD+ levels decrease with age and physiological changes, which is associated with metabolic abnormalities such as obesity and diabetes. NAD+ boosters, including NMN and nicotinamide riboside (NR), are used to treat metabolic disorders. Obesity, diabetes, and aging can cause a decrease in intracellular NAD+ levels, leading to metabolic dysfunction. NMN catalyzes the biosynthesis of NAD+ in mammals, participating in and regulating the body's endocrine system. This helps protect and repair pancreatic islet function, increase insulin secretion, and prevent and treat metabolic diseases such as diabetes and obesity. NMN can be used as a treatment for metabolic diseases caused by overnutrition during pregnancy and postpartum period.

NMN can significantly improve age-related physiological decline, such as inhibiting age-related weight gain, enhancing energy metabolism, improving insulin sensitivity and plasma lipid profile, and improving eye function. NMN can prevent age-related gene expression changes in a tissue-specific manner and enhance mitochondrial oxidative metabolism in skeletal muscle, partially mediating its anti-aging effects. In the long term, the addition of NMN to drinking water has successfully reversed age-related weight gain and improved energy metabolism and insulin sensitivity.

Increasing NMN levels can also reduce hemoglobin content in infarcted tissue, alleviate bleeding and edema, reduce oxidative toxic damage to brain tissue caused by oxidative stress, increase the content of NAD+ and NADH in the heart, restore NAD+ levels in myocardial cells during cardiac ischemia, and increase the deacetylase activity of histone deacetylase (also known as silent regulatory protein, Sirt1) and the expression level of genes related to mitomycin function, which has good clinical application prospects.

What Are The Applications Of NMN Powder Bulk?

Healthcare

Anti-aging: NMN is a precursor to NAD+. Supplementing with NMN can increase NAD+ levels in the body, enhance cellular energy metabolism and DNA repair, and slow the aging process.

Metabolic Diseases: Improves insulin sensitivity, regulates blood sugar and lipids, and has a positive impact on metabolic diseases such as diabetes and obesity.

Cardiovascular Diseases: Protects heart function, reduces ischemia-reperfusion injury, and reduces the risk of cardiovascular disease.

Neurodegenerative Diseases: Enhances nerve cell energy metabolism, improves cognitive function, and has some efficacy in treating Alzheimer's disease and other conditions.

Health Products

Dietary Supplements NMN: As a direct precursor of NAD+, it is formulated into health foods to help improve energy metabolism and slow aging.

Cosmetics

Anti-aging skincare: Promotes energy metabolism in skin cells, reduces wrinkles and dark spots, and improves skin elasticity and radiance.

Food additives

Functional foods: Added to beverages, dairy products, and other products to enhance their health benefits.

Research fields

Experimental research: Used in cell and animal experiments to study NAD+ metabolism, aging mechanisms, and related diseases.

Drug development: Developed as a potential drug candidate for the treatment of metabolic diseases, neurodegenerative diseases, and other diseases.

NMN Power Bulk--Popular Anti-Aging Product

NMN Power Bulk is a naturally occurring bioactive nucleotide that serves as a precursor to nicotinamide adenine dinucleotide (NAD+) and an intermediate in NAD+ biosynthesis. The function of NMN is primarily exerted through NAD+. Let's first understand NAD+.

NAD+ and its Relationship with Aging

NAD+ is the oxidized form of NAD+, widely distributed throughout all cells of the human body. It participates in thousands of biocatalytic reactions and is an essential coenzyme for redox reactions in the body, central to our energy metabolism.

NAD+ plays a crucial role in numerous biological processes, including cell death, aging, gene expression, neuroinflammation, and DNA repair.

NAD+ levels decrease with aging. The average NAD+ concentration in adult skin tissue is several times lower than that in newborns. Magnetic resonance imaging studies have shown that NAD+ concentrations in the human brain decrease by 10% to 25% from adolescence to old age. In addition, many factors may accelerate NAD+ degradation, including DNA damage, chronic inflammation, oxidative stress, and increased activity of NAD+-consuming enzymes.

Changes in NAD+ during aging

Increased NAD+ depletion in human cells or tissues can lead to reduced mitochondrial energy production in various organs, including the brain, adipose tissue, skin, liver, skeletal muscle, and pancreas. Consequently, decreased NAD+ levels lead to reduced mitochondrial energy production, contributing to aging and various age-related diseases, such as cognitive impairment, DNA damage, hearing and vision loss, cognitive and motor impairment, immune deficiency, arthritis caused by dysregulated autoimmune inflammatory responses, metabolic disorders, and cardiovascular disease.

Since NAD+ cannot be orally absorbed or cross cell membranes, NAD+ concentrations can be increased by supplementing the diet with foods rich in NAD+ precursors or taking nutritional supplements.

The Health Effects of NMN Supplementation

Research has shown that supplementing with NMN Power Bulk can increase NAD+ levels in the body through biosynthetic pathways, thereby delaying, improving, and preventing various aging-related phenotypes, reversing the aging process, and preventing or alleviating various age-related diseases. These include improving brain function, preventing neurodegeneration, preventing pulmonary fibrosis, improving respiratory function, improving liver function, reducing liver steatosis, enhancing immune cell function, reducing inflammation, reducing muscle atrophy, improving mitochondrial function, enhancing muscle vitality, and protecting the skin from photodamage. Some of these effects are listed below.

Benefits of NMN Supplementation

NMN's Brain Microvascular Protective Effects: During aging, increased oxidative stress and brain microvascular endothelial dysfunction impair neurovascular coupling (NVC), leading to cognitive decline. Studies have found that NMN supplementation can improve microvascular endothelial function in aged mice, reduce endothelial oxidative stress, rescue NO-mediated neurovascular coupling, and improve mitochondrial function.

NMN's Effects on Obesity and Related Liver Diseases: A long-term high-fat diet is associated with various chronic metabolic diseases, including obesity. Exercise can partially offset the effects of obesity, in part due to increased NAD+, which in turn upregulates mitochondrial activity. Animal studies have shown that administration of NMN, a precursor to NAD+, can increase NAD+ levels in muscle and liver, improving citrate synthase activity in muscle and liver induced by a high-fat diet, potentially helping to intervene in diet-related metabolic disorders such as obesity and non-alcoholic fatty liver disease.

NMN's Effects on Offspring Metabolism: Parental overweight (BMI > 25) affects offspring metabolism and is considered a key factor in increasing the risk of overweight or obesity in early life. This is closely associated with the prevalence of obesity and related metabolic disorders in later life. Studies have shown that maternal obesity is associated with non-alcoholic fatty liver disease (NAFLD) in adolescent offspring. NMN supplementation can reduce hepatic lipid accumulation in offspring of obese mothers, likely due to NMN decreasing genes involved in hepatic fat synthesis, transport, and uptake, while increasing genes involved in fatty acid oxidation.

How to Supplement NMN Power Bulk?

Supplement Forms

Capsules: This is the most common form of supplementation, clinically tested in humans and proven to have high bioavailability. Enteric-coated capsules protect NMN from gastric acid, further enhancing absorption.

Powder: Can be dissolved in water and taken, making it suitable for those with swallowing difficulties, but bioavailability may be slightly lower than capsules.

Food Sources

NMN Power Bulk is widely found in everyday foods, naturally occurring in a variety of foods such as cauliflower, cabbage, cucumber, Chinese cabbage, broccoli, edamame, avocado, tomatoes, mushrooms, raw beef, and shrimp. NMN content in vegetables and fruits ranges from 0.25 to 1.88 mg/100 g, while raw beef and shrimp contain relatively lower levels than plant-based foods (0.06 to 0.42 mg/100 g).

Compared to other NAD+ precursors, NMN dominates the anti-aging market, with a wide variety of NMN products currently available from various brands. This is because NMN is the most direct precursor of NAD+ and can be easily converted directly into NAD+ via the NMNAT enzyme. This means that NMN can more efficiently increase NAD+ levels.

While NMN may offer advantages in terms of conversion speed, efficacy, and stability, it's important to note that the pharmacokinetics and metabolic mechanisms of NMN are still under investigation. Not all cells are capable of converting all NAD+ precursors into NAD+. Furthermore, the absorption and utilization of these NAD+ precursors vary in different tissues and organs.

Currently, existing human clinical trials have not shown any side effects from NMN. However, the efficacy and safety of NMN warrant further attention. There is currently no official recommended intake for NMN. However, studies have shown that doses of up to 1250 mg/day of NMN do not cause adverse side effects or harm health.