What Does PDRN Powder Do For Skin?

PDRN Powder, also known as Sodium DNA, is a mixture of active polynucleotides with a molecular weight range of 50~1500 kDa. It is currently extracted and purified from Male Salmon. Its DNA is 98% similar to that of humans. Its unique molecular structure gives it strong biological activity, stability and ultra-high bioavailability. It is similar to polynucleotides (PN), but has a more significant anti-aging effect. It is mainly used to improve skin condition, promote the regeneration of collagen and elastic fibers, relieve inflammation, and can easily penetrate the skin epidermis and reach the bottom of the skin, awakening the skin's repair and regeneration ability.

What Skin Problems Can PDRN Powder Solve?

1. Skin regeneration

PDRN is a hydrolyzed regenerative tissue that can quickly induce tissue regeneration, promote cell regeneration, and accelerate wound healing. It can activate the skin's own regenerative ability and replenish elastic fibers lost due to aging. When it enters the human body, it can combine with cells to restore the internal environment of the skin to its optimal state, thereby repairing skin damaged by physical, chemical stimulation and ultraviolet rays.

2. Strong compatibility

It has a high similarity with human DNA bases of up to 98%, and has a strong cell tissue repair ability. It can improve the physiological conditions inside damaged skin, restore the internal environment of the skin to normal, and fundamentally solve skin problems. PDRN extracted from Male Salmon will not produce an immune response when used on the human body, and its unique compatibility makes PDRN more practical.

3. Long-lasting anti-aging

The mechanism of action of PDRN Powder is the participation of adenosine A2A receptors. It specifically stimulates the A2A adenosine receptors on the cell surface, thereby promoting the release of cytokines, producing anti-inflammatory effects, and repairing damaged cells. Receptors cause osteoblasts, fibroblasts, and adipocytes to proliferate. In addition, VEGF and angiogenin are also released with the receptors to improve blood circulation, make the skin full, plump, and translucent, and achieve a lasting anti-aging effect.

4. Repair skin barrier

It can promote the secretion of vascular endothelial growth factor, accelerate the migration, proliferation, and angiogenesis of vascular endothelial cells. It can effectively improve the microcirculation of the skin, provide more oxygen and nutrients for skin cells, accelerate the repair and regeneration of skin tissue, promote the repair and reconstruction of the skin barrier, and enhance the skin's moisturizing ability and resistance. It also has the ability to promote tissue repair, accelerate the regeneration and healing of damaged skin tissue, enable sensitive muscles to effectively resist external stimuli, increase skin thickness and elasticity, and improve skin sensitivity.

5. Anti-inflammatory

Inflammation at the bottom of the skin will cause vascular dilation, cause skin redness and swelling, stimulate nerve endings, compress local tissues, and produce pain. PDRN can significantly inhibit inflammatory reactions and reduce symptoms such as skin redness, swelling, and pain. It can regulate the expression of inflammatory factors, inhibit the excessive occurrence of inflammatory reactions, promote the production of anti-inflammatory factors, and inhibit the release of pro-inflammatory factors. PDRN assists in the treatment of various inflammatory skin diseases, increases skin moisture, enhances skin thickness, improves skin sensitivity, and is effective for neurogenic inflammation and rosacea.

6. Melanin suppression

It can reduce the production of melanin in cells, reduce tyrosinase activity, inhibit the expression of related transcription factors and proteins, and has a certain effect on chloasma and photoaging spots.

What Are The Mechanisms Of Action Of PDRN?

1. A2A receptor-mediated repair pathway

Activation of adenosine A2A receptors is the core mechanism. It increases cAMP concentration, inhibits the MAPK/NF-κB inflammatory pathway, and downregulates Fli1 gene expression, thereby relieving the inhibition of CTGF, thereby promoting collagen synthesis. A2A receptor antagonists can completely block the pro-repair effect of PDRN Powder, verifying the necessity of this pathway.

2. "Remedial pathway" for DNA damage repair

Provide deoxynucleotide raw materials, directly repair DNA chain breaks caused by ultraviolet or oxidative stress through the remedial synthesis pathway, reduce CPDs accumulation, and restore telomere stability, delaying cell aging. In vitro experiments have confirmed that the DNA damage repair rate of fibroblasts after UVB radiation is increased by 2 times.

3. Antioxidation and mitochondrial function regulation

By inhibiting the excessive generation of ROS, protecting mitochondrial membrane potential, reducing cell apoptosis (reduced Bax/Bcl-2 ratio), and activating the SIRT1 pathway, cell life is extended.

4. Dynamic balance of extracellular matrix

By inhibiting the activity of MMP-1 and elastase, collagen degradation is reduced; at the same time, fibronectin and laminin deposition are stimulated to enhance the structural stability of the dermis.

How Does PDRN Fight Against Aging?

Antioxidant properties

It has strong antioxidant capacity and can effectively inhibit the expression of MMP-1 gene in skin fibroblasts, reduce oxidative stress, and thus slow down the skin aging process.

Improve collagen synthesis

It can promote the synthesis of collagen and inhibit the expression of elastase and MMP-1, both of which play a key role in skin aging and wrinkle formation.

Cell proliferation and migration

PDRN Powder can increase the proliferation of skin cells and promote cell migration, which helps skin repair and regeneration.

Anti-apoptosis

By activating adenosine A2A receptors, it induces intracellular cAMP activation, promotes the expression of anti-apoptosis related proteins, and inhibits the expression of apoptosis protein activating factor-1 and Caspase-3 and Caspase-9.

Angiogenesis

By activating adenosine A2A receptors, it promotes the secretion of vascular endothelial growth factor, enhances angiogenesis, improves microcirculation, and delays skin aging.

Conclusion

PDRN Powder has many benefits for the skin and is an important ingredient in skin care formulas. Its application prospects lie not only in the innovation of ingredients, but also in the profound subversion of traditional beauty concepts. With the advancement of science and technology and the improvement of consumer awareness, the beauty industry will continue to develop in the direction of efficiency, safety and personalization. Its market potential is gradually being tapped, especially in the fields of skin repair, anti-aging and medical beauty, showing significant therapeutic effects. It plays a key role in the innovative development of the beauty industry, and its scientificity and effectiveness provide new development momentum for the industry.

Shaanxi Yuantai Biotechnology Co., Ltd. (YTBIO) was established in 2014 and is a global healthcare company headquartered in Xi'an and with a production base in Weinan. We focus on health food ingredients (such as herbal extracts, creatine monohydrate) and cosmetic ingredients (including sponge thorns, retinol, glutathione and arbutin). We work with partners in Europe, the United States, Southeast Asia and South Korea. We have a warehouse in Rotterdam for EU distribution and plan to set up a warehouse in the United States. We prioritize quality and hold certifications such as HACCP, ISO9001, ISO22000, HALAL, KOSHER, FDA, EU&NOP Organic and NMPA. We also assist Korean customers with KFDA registration. Our goal is to establish long-term partnerships through high-quality products and professional services. If you have any questions, please contact sales@sxytorganic.com or +86-029-86478251 / +86-029-86119593.